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provides coniferyl ferulate(CAS#:60767-80-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
This study aims to determine the association between temperature and preeclampsia and whether it is affected by seasonality and rural/urban lifestyle.
This cohort study included women who delivered at our medical center from 2004 to 2013 (31,101 women, 64,566 deliveries). Temperature values were obtained from a spatiotemporally resolved estimation model performing predictions at a 1×1km spatial resolution. In “Warm” pregnancies >50% of gestation occurred during the spring-summer period. In cold pregnancies >50% of gestation occurred during the fall and winter. Generalized estimating equation multivariable models were used to estimate the association between temperature and incidence of preeclampsia.
1) The incidence of preeclampsia in at least one pregnancy was 7% (2173/64,566); 2) during “warm” pregnancies, an elevation of one IQR of the average temperature in the 1st or the 3rd trimesters was associated with an increased risk to develop preeclampsia [patients with Jewish ethnicity: 1st trimester: relative risk (RR) of 2.38(95%CI 1.50; 3.80), 3rd trimester 1.94(95%CI 1.34;2.81); Bedouins: 1st trimester: RR = 2.91(95%CI 1.98;4.28), 3rd trimester: RR = 2.37(95%CI 1.75;3.20)]; 3) In “cold” pregnancies, an elevation of one IQR of average temperature was associated with a lower risk to develop preeclampsia among patients with Bedouin-Arab ethnicity RR = 0.68 (95% CI 0.49-0.94) for 1st trimester and RR = 0.62 (95% CI 0.44-0.87) for 3rd trimester.
1) Elevated averaged temperature during the 1st or 3rd trimesters in “warm” pregnancies confer an increased risk for the development of preeclampsia, especially in nomadic patients; 2) Of interest, during cold pregnancies, elevated averaged temperature was associated with a lower risk to develop preeclampsia for nomadic patients. 3) These findings suggest temperature might be associated with perturbations in maternal heat homeostasis resulting in reallocation of energy resources and their availability to the fetus that may increase the risk for preeclampsia. This observation is especially relevant in the context of global warming and its effects on maternal/fetal reproductive health.
Temperature and preeclampsia: Epidemiological evidence that perturbation in maternal heat homeostasis affects pregnancy outcome
Sagi Shashar, Formal analysis, Investigation, Methodology, Writing - original draft,1,* Itai Kloog, Conceptualization, Funding acquisition, Methodology, Supervision,2 Offer Erez, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing - review & editing,3 Alexandra Shtein, Data curation, Methodology,2 Maayan Yitshak-Sade, Conceptualization, Data curation, Methodology,4 Batia Sarov, Supervision,5 and Lena Novack, Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation, Writing - review & editing1 Frank T. Spradley, Editor
Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments. We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira to be sequenced. The L. biflexa genome has 3,590 protein-coding genes distributed across three circular replicons: the major 3,604 chromosome, a smaller 278-kb replicon that also carries essential genes, and a third 74-kb replicon. Comparative sequence analysis provides evidence that L. biflexa is an excellent model for the study of Leptospira evolution; we conclude that 2052 genes (61%) represent a progenitor genome that existed before divergence of pathogenic and saprophytic Leptospira species. Comparisons of the L. biflexa genome with two pathogenic Leptospira species reveal several major findings. Nearly one-third of the L. biflexa genes are absent in pathogenic Leptospira. We suggest that once incorporated into the L. biflexa genome, laterally transferred DNA undergoes minimal rearrangement due to physical restrictions imposed by high gene density and limited presence of transposable elements. In contrast, the genomes of pathogenic Leptospira species undergo frequent rearrangements, often involving recombination between insertion sequences. Identification of genes common to the two pathogenic species, L. borgpetersenii and L. interrogans, but absent in L. biflexa, is consistent with a role for these genes in pathogenesis. Differences in environmental sensing capacities of L. biflexa, L. borgpetersenii, and L. interrogans suggest a model which postulates that loss of signal transduction functions in L. borgpetersenii has impaired its survival outside a mammalian host, whereas L. interrogans has retained environmental sensory functions that facilitate disease transmission through water.
Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis
Mathieu Picardeau,# 1 Dieter M. Bulach,# 2 , 3 , 4 Christiane Bouchier, 5 Richard L. Zuerner, 6 Nora Zidane, 5 Peter J. Wilson, 7 Sophie Creno, 5 Elizabeth S. Kuczek, 7 Simona Bommezzadri, 1 John C. Davis, 7 Annette McGrath, 7 Matthew J. Johnson, 7 Caroline Boursaux-Eude, 8 Torsten Seemann, 2 Zoe Rouy, 9 Ross L. Coppel, 2 , 3 Julian I. Rood, 2 , 3 , 4 Aurelie Lajus, 9 John K. Davies, 2 , 3 , 4 Claudine Medigue, 9 , 10 and Ben Adler 2 , 3 , 4 , * Dana Davis, Academic Editor
In the title compound, [AgCl(C7H7N3O2S)(C18H15P)2], the AgI ion is in a distorted tetrahedral coordination environment formed by P atoms from two triphenylphosphane ligands, one terminal S atom from the 1-(4-nitrophenyl)thiourea ligand and a chloride ion. In the crystal, bifurcated (N—H)2⋯Cl hydrogen bonds [with graph-set motif R 2 1(6)] connect complex molecules, forming zigzag chains along . These chains are linked via weak C—H⋯O hydrogen bonds, forming a two-dimensional network parallel to (100). An intramolecular N—H⋯Cl hydrogen bond forming an S(6) ring is also observed.
crystal structure, N—H⋯Cl hydrogen bonding, intramolecular hydrogen bonding, intermolecular hydrogen bonding
Crystal structure of chlorido[1-(4-nitrophenyl)thiourea-κS]bis(triphenylphosphane-κP)silver(I)
Arunpatcha Nimthong-Roldan,a Paramee Sripa,b and Yupa Wattanakanjanab,*
2017 Jun 1;