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Jatrorrhizine

$173

  • Brand : BIOFRON

  • Catalogue Number : BD-D0576

  • Specification : HPLC≥98%

  • CAS number : 3621-38-3

  • Formula : C20H20NO4

  • Molecular Weight : 338.4

  • PUBCHEM ID : 72323

  • Volume : 20mg

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Catalogue Number

BD-D0576

Analysis Method

Specification

HPLC≥98%

Storage

-20℃

Molecular Weight

338.4

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the barks of Phellodendron chinense Schneid.

Structure Type

Category

SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC

Synonyms

Neprotine/YATROIZINE HCL/Neprotin/Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-/3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium/3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium/NEPROTINE IODIDE/Jateorrhizine/Jatrorrhizine/jatorrhizine/Jateorhizine/Jatrorrhizin/NEPROTINE HCL/7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium/Yatrorizine

IUPAC Name

Applications

Effect of jatrorrhizine, berberine, Huanglian Decoction and compound-mimic prescription on blood glucose in mice.[Reference: WebLink]Chinese Traditional & Herbal Drugs, 2005, 36(4):548-51. To study the hypoglycemic activity of Jatrorrhizine (Jat) and compare the effects of Jat, berberine (Ber), Huanglian Decoction (HLD), and compounds-mimic prescription (Ber+Jat) on blood glucose level in mice. METHODS AND RESULTS:TLC-scanning method was adopted for the determination of Ber and Jat in HLD. Ber+Jat was made artificially according to the result of the TLC-scanning. Diabetic model mice were made by ip alloxan, diabetic and normal mice were given Jat, Ber, HLD, and Ber+Jat in different dose by ig and applied in the study. Blood glucose level was analyzed by spectrophotometry with glucose-oxidase. Jat, Ber, HLD, and Ber+Jat decreased blood glucose level of diabetic and normal mice at different degrees. HLD showed the most significant hypoglycemic activity. Jat also possessed the function of decreasing blood glucose, which was less than that of Ber at the same dose. There was no significant difference between Ber+Jat and Ber. CONCLUSIONS: It implies that there are some other hypoglycemic ingredients in HLD besides Ber and Jat. Jat has no evident synergistic or antagonistic action when coexisted with Ber in natural ratio.

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

MXTLAHSTUOXGQF-UHFFFAOYSA-O

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:3621-38-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31685744

Abstract

Phellodendron bark (“Obaku”) is an important crude drug used in Kampo-medicine. Recently, powder formulation of phellodendron bark was approved as an “efficacious treatment for bruise, sprain, and periodontal diseases”, and it has been marketed as an OTC agent. To obtain this approval, the examination of quality control-related characteristics is necessary. Therefore, we established a quantitative method for jatrorrhizine, palmatine, and berberine determination. In this study, we compared the contents of the three constituents obtained from the extracts of Japanese and Chinese phellodendron bark and found remarkable difference.

KEYWORDS

berberine; jatrorrhizine; palmatine; powdered phellodendron bark formulation

Title

[Simultaneous Quantitative Analysis of Berberine and Other Alkaloids in Powdered Phellodendron Bark].

Author

Kamimura S1, Nishihara M1, Osumi Y1, Shiota H1.

Publish date

2019;

PMID

31577283

Abstract

Two novel Pt(ii) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates.

Title

Two telomerase-targeting Pt(ii) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells.

Author

Qin QP 1, Wang ZF , Huang XL , Tan MX , Luo ZH , Wang SL , Zou BQ , Liang H .

Publish date

2019 Oct 14

PMID

31563806

Abstract

Two highly active anticancer Pt(II) complexes, [Pt(Jat1)Cl]Cl (Pt1) and [Pt(Jat2)Cl]Cl (Pt2), containing jatrorrhizine derivative ligands (Jat1 and Jat2) are described. Cell intake study showed high accumulation in cell nuclear fraction. Pt1 and Pt2 exhibited high selectivity for HeLa cancer cells (IC50 = 15.01 ± 1.05 nM and 1.00 ± 0.17 nM) comparing with HL-7702 normal cells (IC50 > 150 μM), by targeting p53 and telomerase. Pt2 containing Jat2 ligand was more potent and showed high selectivity for telomerase. It also caused mitochondria and DNA damage, sub-G1 phase arrest, and a high rate of cell apoptosis at the low dose of 1.00 nM. The HeLa tumor inhibition rate (TIR) of Pt2 was 48.8%, which was even higher than cisplatin (35.2%). In addition, Pt2 displayed green luminescent property and potent telomerase inhibition. Our findings demonstrated the promising development of platinum(II) complexes containing jatrorrhizine derivatives as novel Pt-based anti-cancer agents.

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

KEYWORDS

Antitcancer activity; Apoptosis; Jatrorrhizine derivatives; Platinum(II) complex; Telomerase; p53

Title

High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives.

Author

Qin QP1, Zou BQ2, Wang ZF3, Huang XL3, Zhang Y4, Tan MX5, Wang SL5, Liang H6.

Publish date

2019 Dec 1