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Jervine

$113

  • Brand : BIOFRON

  • Catalogue Number : BF-J2001

  • Specification : 98%

  • CAS number : 469-59-0

  • Formula : C27H39NO3

  • Molecular Weight : 425.6

  • PUBCHEM ID : 10098

  • Volume : 20mg

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Catalogue Number

BF-J2001

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

425.6

Appearance

White crystalline powder

Botanical Source

herbs of Veratrum nigrum L.

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1

Synonyms

17,23β-Epoxy-3β-hydroxyveratraman-11-one/(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one/(3β,22S,23R)-3-Hydroxy-17,23-epoxyveratraman-11-one/Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-β,23-β)- (9CI)/DL-ISOLEUCINE GRADE II/(3b,23b)-17,23-Epoxy-3-hydroxyveratraman-11-one/4-27-00-03590/4-27-00-03590 (Beilstein Handbook Reference)/(3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one/Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-/11-KETOCYCLOPAMINE/Iervin/Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)- (9CI)/jerwiny/Jervin-11-one/Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-, (3S,3'R,3a'S,6'S,6aS,6bS,7a'R,9R,11aS,11bR)-

IUPAC Name

(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethylspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one

Density

1.2±0.1 g/cm3

Solubility

Flash Point

311.8±30.1 °C

Boiling Point

592.0±50.0 °C at 760 mmHg

Melting Point

242- 244ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2934990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:469-59-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31207578

Abstract

Jervine is a natural teratogenic compound isolated from Veratrum californicum. In this study, for the first time, we revealed a novel activity of jervine in sensitizing the anti-proliferation effect of doxorubicin (DOX). We demonstrated that the synergistic mechanism was related to the intracellular accumulation of DOX via modulating ABCB1 transportation. Jervine did not affect the expression of ABCB1 in mRNA nor protein levels. However, jervine increased the ATPase activity of ABCB1 and possibly served as a substrate of ABCB1. The molecular docking results indicated that jervine was bound to a closed ABCB1 conformation and blocked drug entrance to the central binding site at the transmembrane domain. The present study identifies jervine acts as a substrate of ABCB1, and has potential to be developed as a novel and potent chemotherapy sensitizer used for patients developing multidrug resistance.

Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

KEYWORDS

ABCB1; Chemotherapy; Drug resistance; Jervine; MCF-7/ADR

Title

Teratogenic jervine increases the activity of doxorubicin in MCF-7/ADR cells by inhibiting ABCB1

Author

Liu M1, Lu X2, Zhang J2, Zhao X3, Zhang W4, Lin X5.

Publish date

2019 Sep

PMID

30871382

Abstract

In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT.

KEYWORDS

Radiotherapy; jervine; pyruvate dehydrogenase (PDH)

Title

The protective role of jervine against radiation-induced gastrointestinal toxicity.

Author

Yakan S1, Aydin T2, Gulmez C3, Ozden O4, Eren Erdogan K5, Daglioglu YK6, Andic F7, Atakisi O8, Cakir A9.

Publish date

2019 Dec

PMID

30668429

Abstract

BACKGROUND:
Veratrum, hellebore is an important plant species of the Liliaceae family and jervine is the characteristic steroidal alkaloid constituent of Veratrum album.

PURPOSE:
In the current study, anti-inflammatory and antioxidant effects of jervine isolated from NH4OH-benzene extract of V. album rhizomes were investigated on CAR induced paw edema in rats.

METHODS/STUDY DESIGN:
In inflammatory study, 50, 100, 200 and 400  mg/kg doses of jervine, 25  mg/kg doses of DIC and IND were orally administered, and the volume of the foots were measured up to their knee arthrosis by plethismometer. After one hour of the oral administration of the all treatments, 0.1 ml of CAR solution (1%) was injected into the foot of the all rat groups and the volume of the foots were measured during 5 h after CAR injection. GPx, SOD, GR, MPO, CAT enzymes activities and GSH, LPO levels of the supernatants of paw homogenates and inflammation biomarkers such as TNF-α and IL-1β in the rats serums were also estimated.

RESULTS:
According to the present results, jervine exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. Inflammation biomarkers such as TNF-α, IL-1β and MPO that increased by CAR injection were suppressed by the administrations of all doses of jervine, IND and DIC. In all paw tissues, LPO levels as indicator of oxidative tissue damage were found to be high in CAR-treated group and it was found to be decreased in all doses of jervine.

CONCLUSION:
Jervine, DIC and IND reduced the negative effects of CAR due to increasing effects on the SOD, CAT, GSH, GPx and GR antioxidants.

Copyright © 2018 Elsevier GmbH. All rights reserved.

KEYWORDS

Acute inflammation; Antioxidants; Carrageenan; Jervine; Veratrum album

Title

Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.

Author

Dumlu FA1, Aydin T2, Odabasoglu F1, Berktas OA3, Kutlu Z4, Erol HS5, Halici MB5, Cadirci E6, Cakir A7.

Publish date

2019 Mar 15


Description :

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.IC50 value:Target: sonic hedgehog is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.