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Kaempferol 3,7,4′-trimethyl ether

$480

  • Brand : BIOFRON

  • Catalogue Number : AV-B03000

  • Specification : 95%

  • CAS number : 15486-34-7

  • Formula : C18H16O6

  • Molecular Weight : 328.32

  • PUBCHEM ID : 5468749

  • Volume : 20mg

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Catalogue Number

AV-B03000

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

-20℃

Molecular Weight

328.32

Appearance

Powder

Botanical Source

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)OC)O)OC

Synonyms

5-hydroxy-3,4',7-trimethoxyflavone/3,7,4'-tri-O-methylkaempherol/3,7,4'-tri-O-methyl-kaempferol/3,4',7-Trimethylkaempferol/4H-1-Benzopyran-4-one, 5-hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-/Kaempferol-3,4',7-trimethyl ether/kaempferol 3,4',7-trimethyl ether/Kaempferol trimethylether/5-hydroxy-3,7,4'-trimethoxyflavone/Kaempferol-3,7,4'-trimethylether/5-Hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one/7-Trimethylkaempferol

IUPAC Name

5-hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Applications

Kaempferol 3,7,4'-trimethyl ether is a flavonol aglycone isolated from the leaves of Siparuna gigantotepala, has antioxidant activity[1].

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

202.2±23.6 °C

Boiling Point

549.0±50.0 °C at 760 mmHg

Melting Point

157-158ºC

InChl

InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)17-18(23-3)16(20)15-13(19)8-12(22-2)9-14(15)24-17/h4-9,19H,1-3H3

InChl Key

WSQWAMGRHJQANC-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:15486-34-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26690189

Abstract

Background: Influenza is a common preventable infectious disease associated with high mortality and morbidity. Vaccination is the most cost-effective measure to prevent influenza, yet the vaccine uptake is known to be low. No previous studies have assessed the rate of seasonal influenza vaccination use among the Lebanese population, nor examined the knowledge and attitudes towards the influenza vaccine. Methods: A cross-sectional survey was performed in 30 pharmacies randomly selected across Lebanon. A 19-item questionnaire was used to record influenza vaccination status, knowledge and attitudes towards the influenza vaccine among the Lebanese general population. Results: The survey response rate was 93%. Among the 640 study participants, the overall 2014-2015 seasonal influenza vaccination rate was 27.6%. The majority of participants (72.4%) reported irregular uptake of the vaccine. Results of the multivariate analysis revealed that elderly people (OR = 2.25, CI = 1.08-4.71), with higher education (OR = 1.42, CI = 1.09-1.84), higher physical activity (OR significantly higher than 1 for all categories), and chronic respiratory disease (OR = 3.24, CI = 1.58-6.62) were more regularly vaccinated, while those who visit the doctor “only when needed” (OR = 0.55, CI = 0.34-0.88) and those who consume more than seven drinks/week (OR = 0.24, CI = 0.09-0.65) were less regularly vaccinated. When introducing knowledge and attitude variables to the model, “thinking that the vaccine was not needed” was the only correlate that demonstrated a significant inverse association with regular influenza vaccination (OR = 0.15; p = 0.017). Conclusions: Suboptimal vaccination rates exist among the Lebanese ambulatory adult population. Clear misinformation on the importance of regular influenza immunization is also highlighted. This evidence underscores a compelling need to raise public awareness regarding the efficacy of the influenza vaccine.

KEYWORDS

influenza, vaccination, immunization, Lebanon

Title

Influenza Vaccination: A Cross-Sectional Survey of Knowledge, Attitude and Practices among the Lebanese Adult Population

Author

Ghada El Khoury* and Pascale Salameh

Publish date

2015 Dec;

PMID

31664132

Abstract

Listening to self-chosen, pleasant and relaxing music reduces pain in fibromyalgia (FM), a chronic centralized pain condition. However, the neural correlates of this effect are fairly unknown. In our study, we wished to investigate the neural correlates of music-induced analgesia (MIA) in FM patients. To do this, we studied 20 FM patients and 20 matched healthy controls (HC) acquiring rs-fMRI with a 3T MRI scanner, and pain data before and after two 5-min auditory conditions: music and noise. We performed resting state functional connectivity (rs-FC) seed-based correlation analyses (SCA) using pain and analgesia-related ROIs to determine the effects before and after the music intervention in FM and HC, and its correlation with pain reports. We found significant differences in baseline rs-FC between FM and HC. Both groups showed changes in rs-FC after the music condition. FM patients reported MIA that was significantly correlated with rs-FC decrease between the angular gyrus, posterior cingulate cortex and precuneus, and rs-FC increase between amygdala and middle frontal gyrus. These areas are related to autobiographical and limbic processes, and auditory attention, suggesting MIA may arise as a consequence of top-down modulation, probably originated by distraction, relaxation, positive emotion, or a combination of these mechanisms.

Subject terms: Chronic pain, Fibromyalgia

Title

Functional connectivity of music-induced analgesia in fibromyalgia

Author

Victor Pando-Naude,1,2,3 Fernando A. Barrios,4 Sarael Alcauter,4 Erick H. Pasaye,5 Lene Vase,6,7 Elvira Brattico,3 Peter Vuust,3,8 and Eduardo A. Garza-Villarrealcorresponding author1,3,9

Publish date

2019;

PMID

22837799

Abstract

The purpose of this study was to investigate hepatic mitochondrial DNA (mtDNA) damage and changes in its encoded products in patients with alcoholic cirrhosis (AC) in order to understand disease pathogenesis. We enrolled 23 patients with AC, 26 alcoholics without cirrhosis, and 25 normal subjects in this study. Hepatic mtDNA deletions were positioned using a combination of long and accurate polymerase chain reaction (LA PCR) and gene sequencing. The mtDNA copy number was measured using real-time quantitative PCR. The expression of the mtDNA-encoded cytochrome c oxidase 2 (cox2) was detected by western blotting. A large deletion of bases located at positions 749-15486 was identified in hepatic mtDNA from AC patients. Moreover, the mtDNA copy number was significantly reduced (P<0.05), and its encoded product, cox2, was significantly downregulated (P<0.05). Collectively, our results suggest that specific deletions and reduced copy numbers of hepatic mtDNA in patients with AC is an important pathogenetic factor.

KEYWORDS

Alcoholic cirrhosis, mitochondria, mitochondrial DNA, cytochrome c oxidase 2

Title

Changes in mitochondrial DNA and its encoded products in alcoholic cirrhosis

Author

Chun Tang, Xianchun Liang, Hongming Liu, Liping Guo, Ruxian Pi, and Juntao Yang

Publish date

2012;