Anticancer,Anti-inflammatory,Antiviral,Antinociceptive activity / Cancer,Inflammatory diseases,Viral infections,Pain
alpha-Glucosidase inhibitory terpenoids from Potentilla fulgens and their quantitative estimation by validated HPLC method PUMID/DOI：DOI: 10.1016/j.jff.2013.03.010 Kumar D, Ghosh R, Pal B C. α-Glucosidase inhibitory terpenoids from Potentilla fulgens, and their quantitative estimation by validated HPLC method[J]. Journal of Functional Foods, 2013, 5(3):1135-1141. Potentilla fulgens is used extensively in traditional system of medicine and as a food additive for the treatment of diabetes mellitus and other ailments. The present study was aimed to isolate and identify the constituents with alpha-glucosidase inhibitory activity. The methanolic extract demonstrated potent inhibitory activity against alpha-glucosidase. Fractionation and purification by silica gel column chromatography and HPLC led to the isolation of five terpenes, namely, hyptadienic acid, tormentic acid, rosamultic acid, 2 alpha,19 alpha-dihydroxy-3-oxo-12-ursen- 28-oic acid beta-D-glucopyranoside ester and kajiichigoside F1 for the first time from this plant. Among these hyptadienic acid, which is an A-ring contracted triterpenoid, was found to be the most potent against alpha-glucosidase. This suggests that the A-ring contracted triterpenes may serve as a class of triterpenes with alpha-glucosidase inhibitory activity. Also, identification of enzyme inhibitory activity of these constituents explains the traditional use of P. fulgens in the management/treatment of diabetes. Quantitative estimation of the compounds was performed using HPLC and the method was validated. (C ) 2013 Elsevier Ltd. All rights reserved. Triterpene saponins from the Chinese drug "Daxueteng" (Caulis sargentodoxae) PUMID/DOI：DOI:10.1055/s-2006-960153 Planta Med. 1991 Oct;57(5):468-70. From the chinese drug "Daxueteng" (Caulis Sargentodoxae: Sargentodoxa cuneata (Oliv.) Rehd. et Wils.; syn. Holboellia cuneata Oliv.) (Sargentodoxaceae), catechin and two known triterpene saponins, rosamultin (7) and kajiichigoside F1 (8) have been isolated. Some hitherto unknown reaction products of the saponins are described. Both 7 and 8 show haemolytic and in vitro antiviral activity. 19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa. PUMID/DOI：15635171 Biol Pharm Bull. 2005 Jan;28(1):101-4. To search for antiinflammtory 19alpha-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated. The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of kaji-ichigoside F1 (1, euscaphic acid 28-O-glucoside) and rosamultin (2, tormentic acid 28-O-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1. These results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
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