White column shaped crystal
L-Arginine/L-ornithine, N-(diaminomethylene)-/H-L-ARG-OH/L-Argnie/(L)-Arginine/L-ARG-OH/L-arginie/AGRININE/arginine/L(+)-Arginine/L-Arginine (9CI)/QVYZ3MYZUM &&L or S Form/Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-/ARGININE, L-/L-a-Amino-d-guanidinovaleric Acid/L-Norvaline, 5-[(aminoiminomethyl)amino]-/(2S)-2-Amino-5-carbamimidamidopentanoic acid/H-ARG-OH/S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid/l-arginin/Arginine, L- (8CI)/Arginine (VAN)/4-04-00-02648/l-arg/5-[(Aminoiminomethyl)amino]-L-norvaline/Arg/N5-(Aminoiminomethyl)-L-ornithine
L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Aqueous acid; Water
367.6±52.0 °C at 760 mmHg
222 °C (dec.)(lit.)
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:74-79-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
We investigated the effects of combining 1 g of l-citrulline and 1 g of l-arginine as oral supplementation on plasma l-arginine levels in healthy males. Oral l-citrulline plus l-arginine supplementation more efficiently increased plasma l-arginine levels than 2 g of l-citrulline or l-arginine, suggesting that oral l-citrulline and l-arginine increase plasma l-arginine levels more effectively in humans when combined.
combination effect; l-arginine, l-citrulline, human; oral intake
The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males.
Suzuki T1, Morita M1, Hayashi T2, Kamimura A1.
L-arginine (Arg) is utilized via multiple pathways to synthesize protein and low-molecular-weight bioactive substances (e.g., nitric oxide, creatine, and polyamines) with enormous physiological importance. Furthermore, Arg regulates cell signaling pathways and gene expression to improve cardiovascular function, augment insulin sensitivity, enhance lean tissue mass, and reduce obesity in humans. Despite its versatile roles, the use of Arg as a dietary supplement is limited due to the lack of data to address concerns over its safety in humans. Data from animal studies are reviewed to assess arginine catabolism and the safety of long-term Arg supplementation. The arginase pathway was responsible for catabolism of 76-85 and 81-96 % Arg in extraintestinal tissues of pigs and rats, respectively. Dietary supplementation with Arg-HCl or the Arg base [315- and 630-mg Arg/(kg BW d) for 91 d] had no adverse effects on male or female pigs. Similarly, no safety issues were observed for male or female rats receiving supplementation with 1.8- and 3.6-g Arg/(kg BW d) for at least 91 d. Intravenous administration of Arg-HCl to gestating sheep at 81 and 180 mg Arg/(kg BW d) is safe for at least 82 and 40 d, respectively. Animals fed conventional diets can well tolerate large amounts of supplemental Arg [up to 630-mg Arg/(kg BW d) in pigs or 3.6-g Arg/(kg BW d) in rats] for 91 d, which are equivalent to 573-mg Arg/(kg BW d) for humans. Collectively, these results can help guide studies to determine the safety of long-term oral administration of Arg in humans.
Amino acids; Catabolism; Dietary supplementation; Health; Nutrition
Catabolism and safety of supplemental L-arginine in animals.
Wu Z1, Hou Y2, Hu S3, Bazer FW3, Meininger CJ4, McNeal CJ5, Wu G6,7,8,9.
This review summarizes the envolving role of L-arginine, the metabolic precursor of nitric oxide (NO), in disease states that produce progressive loss of kidney function. Hypertension and hypertensive nephrosclerosis manifested in the Dahl/Rapp salt-sensitive rat are exquisitely sensitive to oral L-arginine, which can completely prevent hypertension and subsequent renal damage in these rats. L-Arginine also has been shown to decrease glomerular sclerosis in the remnant kidney model and improve renal hemodynamics and function in animal models of diabetes mellitus. Finally, accumulation of inhibitors of NO production occurs in renal failure and may contribute to hypertension in these patients. Understanding the role of L-arginine and the L-arginine:NO pathway in diseases that produce progressive renal failure may provide new approaches to management.
L-arginine and arginine analogs in progressive renal failure.