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L-Aspartic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L2021

  • Specification : 98%

  • CAS number : 56-84-8

  • Formula : C4H7NO4

  • Molecular Weight : 133.1

  • PUBCHEM ID : 5960

  • Volume : 20mg

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Catalogue Number

BF-L2021

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

133.1

Appearance

White crystalline powder

Botanical Source

synthesis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C(C(C(=O)O)N)C(=O)O

Synonyms

asparagic acid/1-amino-1,2-carboxyethane/δ-aspartic acid/d-Asp/QVYZ1VQ &&D or R Form/(-)-Aspartic acid/(2R)-2-Aminosuccinic acid/(2R)-2-aminobutanedioic acid/hydrogen D-aspartate/L-Asparticacid/(R)-(−)-Aminosuccinic acid/D-(-)-Aspartic acid/Acide (2R)-2-aminosuccinique/L-Aspartic acid/aspartic acid D-form/Aspartic acid, D-/D-Aspartic acid/H-D-Asp-OH/H-Asp-OH

IUPAC Name

(2S)-2-aminobutanedioic acid

Density

1.5±0.1 g/cm3

Solubility

Aqueous acid

Flash Point

113.5±24.6 °C

Boiling Point

264.1±30.0 °C at 760 mmHg

Melting Point

>300 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2922490000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:56-84-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32058290

Abstract

For the compendial related substances test of l-aspartic acid (Asp) and glycine (Gly), two separate reversed-phase ion-pair high-performance liquid chromatography methods coupled with charged aerosol and ultraviolet detection were developed. Separation of all putative impurities, in particular of the related carboxylic and amino acids, was achieved using volatile perfluorocarboxylic acids as ion-pairing reagents on a polar embedded C18 stationary phase. It was shown that an adjustment of the evaporation temperature of the charged aerosol detector (CAD) was an efficient strategy for meeting the required quantitation limits, when dealing with non-volatile analytes. It was also demonstrated that the usage of a two detector setup can be beneficial for extending the detection range and providing accurate quantitation of low level impurities (LOQs from 5 to 50 ng on column). Both methods were validated with accordance to ICH guideline Q2(R1) assessing specificity, linearity, accuracy, precision, and robustness. Several batches of Asp and Gly were tested for related substances using the developed methods. The purity of each sample was higher than 99.7 %. Coupled charged aerosol and UV detection proved to be a more simple, robust and selective alternative to established derivatization procedures such as the Amino-Acid-Analyser (AAA) for the impurity profiling of amino acids, and should thus be considered for implementation into pharmacopoeial monographs in the future.

Copyright © 2020 Elsevier B.V. All rights reserved.

KEYWORDS

Aspartic acid (Asp); Charged aerosol detector (CAD); Glycine (Gly); High-performance liquid chromatography (HPLC); Impurity profiling; Ultraviolet detector (UV)

Title

Impurity profiling of l-aspartic acid and glycine using high-performance liquid chromatography coupled with charged aerosol and ultraviolet detection.

Author

Pawellek R1, Schilling K1, Holzgrabe U2.

Publish date

2020 May 10


Description :

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.