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L-Cystine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3010

  • Specification : 95%

  • CAS number : 56-89-3

  • Formula : C6H12N2O4S2

  • Molecular Weight : 240.3

  • PUBCHEM ID : 67678

  • Volume : 500mg

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Catalogue Number

BF-L3010

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

2-8°C

Molecular Weight

240.3

Appearance

White crystal

Botanical Source

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C(C(C(=O)O)N)SSCC(C(=O)O)N

Synonyms

L-Dicysteine/(CYS)2/L-CYTISINE/CYSTINE, L-/L-Cystine (9CI)/(R,R)-3,3'-Dithiobis(2-aminopropionicacid)/oxidized L-cysteine/Acide (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoïque)/[3H]-Cystine/Cystine, L- (8CI)Dicysteine/L-Cystine/cystine/L-(-)-Cystine/(2R,2'R)-3,3'-Disulfanediylbis(2-aminopropansaure)/Cystin/Cystine (L)-/1-cystine/Nephrin/(-)-Cystine/(H-Cys-OH)2/(R,R)-cystine/l-cystin/h-(cys)/.β.,.β.'-Diamino-.β.,.β.'-dicarboxydiethyl disulfide/Acetylcysteine Impurity 1

IUPAC Name

(2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]disulfanyl]propanoic acid

Density

1.6±0.1 g/cm3

Solubility

Aqueous base

Flash Point

237.0±28.7 °C

Boiling Point

468.2±45.0 °C at 760 mmHg

Melting Point

260-261ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2930900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:56-89-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29571572

Abstract

To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl ester (CME), a series of l-cystine diamides with or without Nα-methylation was designed, synthesized, and evaluated for their inhibitory activity of l-cystine crystallization. l-Cystine diamides 2a-i without Nα-methylation were found to be potent inhibitors of l-cystine crystallization while Nα-methylation of l-cystine diamides resulted in derivatives 3b-i devoid of any inhibitory activity of l-cystine crystallization. Computational modeling indicates that Nα-methylation leads to significant decrease in binding of the l-cystine diamides to l-cystine crystal surface. Among the l-cystine diamides 2a-i, l-cystine bismorpholide (CDMOR, LH707, 2g) and l-cystine bis(N’-methylpiperazide) (CDNMP, LH708, 2h) are the most potent inhibitors of l-cystine crystallization.

Copyright © 2018 Elsevier Ltd. All rights reserved.

KEYWORDS

Crystallization inhibition; Cystine diamide; Cystinuria; Molecular imposter

Title

Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.

Author

Yang Y1, Albanyan H1, Lee S1, Aloysius H1, Liang JJ2, Kholodovych V3, Sahota A4, Hu L5.

Publish date

2018 May 1

PMID

27409142

Abstract

l-Cystine bismorpholide (1a) and l-cystine bis(N’-methylpiperazide) (1b) were seven and twenty-four times more effective than l-cystine dimethyl ester (CDME) in increasing the metastable supersaturation range of l-cystine, respectively, effectively inhibiting l-cystinecrystallization. This behavior can be attributed to inhibition of crystal growth at microscopic length scale, as revealed by atomic force microscopy. Both 1a and 1b are more stable than CDME, and 1b was effective in vivo in a knockout mouse model of cystinuria.

Title

l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.

Author

Hu L1, Yang Y1, Aloysius H1, Albanyan H1, Yang M2, Liang JJ3, Yu A4, Shtukenberg A4, Poloni LN4, Kholodovych V1,5, Tischfield JA2, Goldfarb DS6, Ward MD4, Sahota A2.

Publish date

2016 Aug 11


Description :

L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.