L-Dicysteine/(CYS)2/L-CYTISINE/CYSTINE, L-/L-Cystine (9CI)/(R,R)-3,3'-Dithiobis(2-aminopropionicacid)/oxidized L-cysteine/Acide (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoïque)/[3H]-Cystine/Cystine, L- (8CI)Dicysteine/L-Cystine/cystine/L-(-)-Cystine/(2R,2'R)-3,3'-Disulfanediylbis(2-aminopropansaure)/Cystin/Cystine (L)-/1-cystine/Nephrin/(-)-Cystine/(H-Cys-OH)2/(R,R)-cystine/l-cystin/h-(cys)/.β.,.β.'-Diamino-.β.,.β.'-dicarboxydiethyl disulfide/Acetylcysteine Impurity 1
468.2±45.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:56-89-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl ester (CME), a series of l-cystine diamides with or without Nα-methylation was designed, synthesized, and evaluated for their inhibitory activity of l-cystine crystallization. l-Cystine diamides 2a-i without Nα-methylation were found to be potent inhibitors of l-cystine crystallization while Nα-methylation of l-cystine diamides resulted in derivatives 3b-i devoid of any inhibitory activity of l-cystine crystallization. Computational modeling indicates that Nα-methylation leads to significant decrease in binding of the l-cystine diamides to l-cystine crystal surface. Among the l-cystine diamides 2a-i, l-cystine bismorpholide (CDMOR, LH707, 2g) and l-cystine bis(N’-methylpiperazide) (CDNMP, LH708, 2h) are the most potent inhibitors of l-cystine crystallization.
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Crystallization inhibition; Cystine diamide; Cystinuria; Molecular imposter
Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.
Yang Y1, Albanyan H1, Lee S1, Aloysius H1, Liang JJ2, Kholodovych V3, Sahota A4, Hu L5.
2018 May 1
l-Cystine bismorpholide (1a) and l-cystine bis(N’-methylpiperazide) (1b) were seven and twenty-four times more effective than l-cystine dimethyl ester (CDME) in increasing the metastable supersaturation range of l-cystine, respectively, effectively inhibiting l-cystinecrystallization. This behavior can be attributed to inhibition of crystal growth at microscopic length scale, as revealed by atomic force microscopy. Both 1a and 1b are more stable than CDME, and 1b was effective in vivo in a knockout mouse model of cystinuria.
l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.
Hu L1, Yang Y1, Aloysius H1, Albanyan H1, Yang M2, Liang JJ3, Yu A4, Shtukenberg A4, Poloni LN4, Kholodovych V1,5, Tischfield JA2, Goldfarb DS6, Ward MD4, Sahota A2.
2016 Aug 11
L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.