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L-Glutamine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3011

  • Specification : 95%

  • CAS number : 56-85-9

  • Formula : C10H17N3O6S

  • Molecular Weight : 146.14

  • PUBCHEM ID : 5961

  • Volume : 500mg

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Catalogue Number

BF-L3011

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

-20℃

Molecular Weight

146.14

Appearance

White crystal

Botanical Source

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C(CC(=O)N)C(C(=O)O)N

Synonyms

(2S)-2-((2S)-2-Aminopropanoylamino)-4-carbamoylbutanoic acid/ZY1&VMYVQ2VZ &&L-L Form/glutaminic acid/Gln/L-Ala-L-Gln/glutamine/L-Gln/Pentanoic acid, 2,5-diamino-5-oxo-, (S)-/L-Alanyl-L-glutamine/Levoglutamide/(S)-5-Amino-2-[(S)-2-aminopropanamido]-5-oxopentanoic acid/L-Glutamine,L-alanyl/2,5-Diamino-5-oxopentanoic acid, (S)-/(2S)-2-amino-4-carbamoylbutanoic acid/Alanyl-glutamine,Glutamine-S/Ala-Gln/L-(+)-Glutamine/2-Aminoglutaramic acid, L-/(S)-(+)-Glutamine/5-Hydroxy-5-imino-L-norvaline/N(2)-L-alanyl-L-glutamine/Glutamine-S/Alanyl-glutamine/L-Norvaline, 5-hydroxy-5-imino-/L-Glutamic Acid g-Amide/L-Glutamic acid γ-amide/N-L-alanyl-L-glutamine/L-Glutamine, N2-L-alanyl-/L-Glutamine/l-alanyl-l-glutamin/l-(+)-glutamic acid-5-amide/L-Glutamic acid 5-amide/H-Ala-Gln-OH/GLUTAMINE, L-/(2S)-5-Amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid/L-Glutamine, L-alanyl-/S(+)-Glutamic acid 5-amide/H-Gln-OH

IUPAC Name

(2S)-2,5-diamino-5-oxopentanoic acid

Density

1.5±0.1 g/cm3

Solubility

Water

Flash Point

167.6±30.7 °C

Boiling Point

353.5±52.0 °C at 760 mmHg

Melting Point

185ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2924190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:56-85-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29895661

Abstract

In 2017, the Food and Drug Administration approved 2 medications for sickle cell anemia (SCA): hydroxyurea for children and l-glutamine for children and adults. The approval of hydroxyurea was long overdue, but the approval of l-glutamine was a surprise to many. Any effective new treatment for SCA is a welcome advance, but there are few published studies of l-glutamine as a specific treatment for SCA. Accordingly, there are many unanswered questions about its efficacy, safety, and role in current therapy.

© 2018 by The American Society of Hematology.

Title

l-Glutamine for sickle cell anemia: more questions than answers.

Author

Quinn CT1.

Publish date

2018 Aug 16

Title

L-glutamine (Endari) for sickle cell disease.

Publish date

2018 Jan 29

PMID

30406980

Title

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.

Author

Anker MS1,2, Haverkamp W1, Anker SD1.

Publish date

2018 Nov 8


Description :

L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.Target: mGluRGlutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders. Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500-900 μmol/L. Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut. The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid-base balance, activated immune cells, and manycancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs.