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L-Phenylalanine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3006

  • Specification : 98%

  • CAS number : 63-91-2

  • Formula : C9H11NO2

  • Molecular Weight : 165.19

  • PUBCHEM ID : 6140

  • Volume : 100mg

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Catalogue Number

BF-L3006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

165.19

Appearance

White crystalline powder

Botanical Source

Glycine max

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C(C=C1)CC(C(=O)O)N

Synonyms

Benzenepropanethioic acid,S-phenyl ester/(S)-phenylalanine/L-Phenylalanine/(2S)-2-amino-3-phenylpropanoic acid/L-PHENYLALININE/α-Amino-β-phenylpropionic acid, L-/H-Phe-OH/Alanine, 3-phenyl-/L-phenylalanine zwitterion/S-phenylalanine/(S)-(-)-Phenylalanine/Thiohydrozimtsaeurephenylester/(S)-a-Amino-b-phenylpropionic Acid/Alanine, phenyl-, L-/L-2-Amino-3-phenylpropionic acid/(S)-2-Amino-3-phenylpropionic acid/(S)-2-Amino-3-phenylpropanoic acid/C6H5CH2CH(NH2)COOH/(S)-a-Aminohydrocinnamic Acid/Phenylalanineα-Aminohydrocinnamic acid, L-/(L)-Phenylalanine/Phenylalanine (VAN)/Phenylalanine, L-/Benzenepropanoic acid, α-amino-, (S)-/l-Phe/PhE/phenyl 4-phenylthiobutanoate/S-Phenyl-3-phenylpropanthioat/β-phenyl-L-alanine/(-)-Phenylalanine(S)-α-Aminobenzenepropanoic acid/3-Phenylpropionyl-phenyl-thioetherα-Amino-β-phenylpropionic acid/3-Phenylthiopropionic acid,S-phenyl ester/(S)-A-Aminobenzenepropanoic Acid/Acetylcysteine Impurity 3

IUPAC Name

(2S)-2-amino-3-phenylpropanoic acid

Density

1.2±0.1 g/cm3

Solubility

Water; Aqueous acid

Flash Point

139.8±24.6 °C

Boiling Point

307.5±30.0 °C at 760 mmHg

Melting Point

270-275ºC (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2922490000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:63-91-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

27132947

Abstract

l-Phe-imprinted cryogel cartridge was prepared for the chiral separation of l-Phe. N-Methacryloyl l-phenylalanine (MAPA) was used as a functional monomer for complexing with l-Phe. The selectivity of the membranes was investigated by using d-Phe, l-Trp, and d-Trp as competitor molecules. The PHEMAPA-l-Trp membranes were 6.4, 4.3, and 5.5 times more selective for l-Phe than d-Phe, l-Trp, and d-Trp, respectively. The PHEMAPA-l-Phe cryogel cartridge was incorporated into the fast protein liquid chromatography (FPLC) equipment and was able to separate D,l-Phe racemic mixture efficiently. The PHEMAPA-l-Phe membranes were shown to be reusable many times without significant loss of the adsorption capacity.

KEYWORDS

Affinity cryogel; PHEMA; amino acid imprinting; chiral separation; l-phenylalanine

Title

Preparation of imprinted cryogel cartridge for chiral separation of l-phenylalanine.

Author

Akgonullu S1, Yavuz H1, Denizli A1.

Publish date

2017 Jun


Description :

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1]Target: Calcium ChannelL-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3].