Catalogue Number
BN-O1286
Analysis Method
Specification
98%(HPLC)
Storage
2-8°C
Molecular Weight
150.13
Appearance
Botanical Source
Structure Type
Category
SMILES
C(C(C(C(C=O)O)O)O)O
Synonyms
6-Deoxy-D-altrose/(2S,3S,4S)-2,3,4,5-Tetrahydroxypentanal/L-Ribose/2-Deoxy-B-D-Lyxo-Hexose/aldehydo-6-Desoxy-D-mannose/aldehydo-L-ribose/D-6-Deoxyaltrose/D-Altrose,6-deoxy/Ribose/6-Deoxyaltrose/L-(+)-Ribos/6-Deoxy-L-altrose
IUPAC Name
(2S,3S,4S)-2,3,4,5-tetrahydroxypentanal
Density
1.5±0.1 g/cm3
Solubility
Flash Point
219.2±23.3 °C
Boiling Point
415.5±38.0 °C at 760 mmHg
Melting Point
81-84ºC
InChl
InChl Key
PYMYPHUHKUWMLA-MROZADKFSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:24259-59-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
27664159
L-Ribose is a synthetic L-form monosaccharide. It is a building block of many novel nucleotide analog anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Between the two enzymes, L-RI is a rare enzyme that was discovered in 1996 by Professor Izumori’s group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms. Recent studies have focused on their potentials for industrial production of L-ribose. This review summarizes the applications of L-RI and MPI for L-ribose production.
Hepatitis B virus; L-Ribose; L-Ribose isomerase; L-Sugar; Mannose-6-phosphate isomerase
L-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for L-ribose production.
Xu Z1,2, Sha Y1,2, Liu C1,2, Li S1,2, Liang J1,2, Zhou J3, Xu H4,5,6.
2016 Nov
31731969
l-Ribose is an important pharmaceutical intermediate that is used in the synthesis of numerous antiviral and anticancer drugs. However, it is a non-natural and expensive rare sugar. Recently, the enzymatic synthesis of l-ribose has attracted considerable attention owing to its considerable advantages over chemical approaches. In this work, a new strategy was developed for the production of l-ribose from the inexpensive starting material l-arabinose. The l-arabinose isomerase (l-AIase) gene from Alicyclobacillus hesperidum and the d-lyxose isomerase (d-LIase) gene from Thermoflavimicrobium dichotomicum were cloned and co-expressed in Escherichia coli, resulting in recombinant cells harboring the vector pCDFDuet-Alhe-LAI/Thdi-DLI. The co-expression system exhibited optimal activity at a temperature of 70 °C and pH 6.0, and the addition of Co2+ enhanced the catalytic activity by 27.8-fold. The system containing 50 g L-1 of recombinant cells were relatively stable up to 55 °C. The co-expression system (50 g L-1 of recombinant cells) afforded 20.9, 39.7, and 50.3 g L-1 of l-ribose from initial l-arabinose concentrations of 100, 300, and 500 g L-1, corresponding to conversion rate of 20.9%, 13.2%, and 10.0%, respectively. Overall, this study provides a viable approach for producing l-ribose from l-arabinose under slightly acidic conditions using a co-expression system harboring l-AIase and d-LIase genes.
Copyright © 2019 Elsevier Inc. All rights reserved.
Co-expression; d-lyxose isomerase; l-Arabinose isomerase; l-arabinose; l-ribose
Production of l-ribose from l-arabinose by co-expression of l-arabinose isomerase and d-lyxose isomerase in Escherichia coli.
Wu H1, Huang J1, Deng Y2, Zhang W3, Mu W4.
2020 Jan
32088757
L-Ribose is a non-naturally occurring pentose that recently has become known for its potential application in the pharmaceutical industry, as it is an ideal starting material for use in synthesizing L-nucleosides analogues, an important class of antiviral drugs. In the past few decades, the synthesis of L-ribose has been mainly undertaken through the chemical route. However, chemical synthesis of L-ribose is difficult to achieve on an industrial scale. Therefore, the biotechnological production of L-ribose has gained considerable attention, as it exhibits many merits over the chemical approaches. The present review focuses on various biotechnological strategies for the production of L-ribose through microbial biotransformation and enzymatic catalysis, and in particular on an analysis and comparison of the synthetic methods and different enzymes. The physiological functions and applications of L-ribose are also elucidated. In addition, different sugar isomerases involved in the production of L-ribose from a number of sources are discussed in detail with regard to their biochemical properties. Furthermore, analysis of the separation issues of L-ribose from the reaction solution and different purification methods is presented.Key points • l -Arabinose, l -ribulose and ribitol can be used to produce l -ribose by enzymes. • Five enzymes are systematically introduced for production of l -ribose. • Microbial transformation and enzymatic methods are promising for yielding l -ribose.
Biological production; Isomerase; L-Arabinose; L-Ribose; L-Ribulose
Microbial and enzymatic strategies for the production of L-ribose.
Chen M1, Wu H2, Zhang W1, Mu W1,3.
2020 Apr
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