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L-Ribose

$52

  • Brand : BIOFRON

  • Catalogue Number : BN-O1286

  • Specification : 98%(HPLC)

  • CAS number : 24259-59-4

  • Formula : C5H10O5

  • Molecular Weight : 150.13

  • PUBCHEM ID : 90428

  • Volume : 20mg

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Catalogue Number

BN-O1286

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

150.13

Appearance

Botanical Source

Structure Type

Category

SMILES

C(C(C(C(C=O)O)O)O)O

Synonyms

6-Deoxy-D-altrose/(2S,3S,4S)-2,3,4,5-Tetrahydroxypentanal/L-Ribose/2-Deoxy-B-D-Lyxo-Hexose/aldehydo-6-Desoxy-D-mannose/aldehydo-L-ribose/D-6-Deoxyaltrose/D-Altrose,6-deoxy/Ribose/6-Deoxyaltrose/L-(+)-Ribos/6-Deoxy-L-altrose

IUPAC Name

(2S,3S,4S)-2,3,4,5-tetrahydroxypentanal

Density

1.5±0.1 g/cm3

Solubility

Flash Point

219.2±23.3 °C

Boiling Point

415.5±38.0 °C at 760 mmHg

Melting Point

81-84ºC

InChl

InChl Key

PYMYPHUHKUWMLA-MROZADKFSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:24259-59-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27664159

Abstract

L-Ribose is a synthetic L-form monosaccharide. It is a building block of many novel nucleotide analog anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Between the two enzymes, L-RI is a rare enzyme that was discovered in 1996 by Professor Izumori’s group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms. Recent studies have focused on their potentials for industrial production of L-ribose. This review summarizes the applications of L-RI and MPI for L-ribose production.

KEYWORDS

Hepatitis B virus; L-Ribose; L-Ribose isomerase; L-Sugar; Mannose-6-phosphate isomerase

Title

L-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for L-ribose production.

Author

Xu Z1,2, Sha Y1,2, Liu C1,2, Li S1,2, Liang J1,2, Zhou J3, Xu H4,5,6.

Publish date

2016 Nov

PMID

31731969

Abstract

l-Ribose is an important pharmaceutical intermediate that is used in the synthesis of numerous antiviral and anticancer drugs. However, it is a non-natural and expensive rare sugar. Recently, the enzymatic synthesis of l-ribose has attracted considerable attention owing to its considerable advantages over chemical approaches. In this work, a new strategy was developed for the production of l-ribose from the inexpensive starting material l-arabinose. The l-arabinose isomerase (l-AIase) gene from Alicyclobacillus hesperidum and the d-lyxose isomerase (d-LIase) gene from Thermoflavimicrobium dichotomicum were cloned and co-expressed in Escherichia coli, resulting in recombinant cells harboring the vector pCDFDuet-Alhe-LAI/Thdi-DLI. The co-expression system exhibited optimal activity at a temperature of 70 °C and pH 6.0, and the addition of Co2+ enhanced the catalytic activity by 27.8-fold. The system containing 50 g L-1 of recombinant cells were relatively stable up to 55 °C. The co-expression system (50 g L-1 of recombinant cells) afforded 20.9, 39.7, and 50.3 g L-1 of l-ribose from initial l-arabinose concentrations of 100, 300, and 500 g L-1, corresponding to conversion rate of 20.9%, 13.2%, and 10.0%, respectively. Overall, this study provides a viable approach for producing l-ribose from l-arabinose under slightly acidic conditions using a co-expression system harboring l-AIase and d-LIase genes.

Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS

Co-expression; d-lyxose isomerase; l-Arabinose isomerase; l-arabinose; l-ribose

Title

Production of l-ribose from l-arabinose by co-expression of l-arabinose isomerase and d-lyxose isomerase in Escherichia coli.

Author

Wu H1, Huang J1, Deng Y2, Zhang W3, Mu W4.

Publish date

2020 Jan

PMID

32088757

Abstract

L-Ribose is a non-naturally occurring pentose that recently has become known for its potential application in the pharmaceutical industry, as it is an ideal starting material for use in synthesizing L-nucleosides analogues, an important class of antiviral drugs. In the past few decades, the synthesis of L-ribose has been mainly undertaken through the chemical route. However, chemical synthesis of L-ribose is difficult to achieve on an industrial scale. Therefore, the biotechnological production of L-ribose has gained considerable attention, as it exhibits many merits over the chemical approaches. The present review focuses on various biotechnological strategies for the production of L-ribose through microbial biotransformation and enzymatic catalysis, and in particular on an analysis and comparison of the synthetic methods and different enzymes. The physiological functions and applications of L-ribose are also elucidated. In addition, different sugar isomerases involved in the production of L-ribose from a number of sources are discussed in detail with regard to their biochemical properties. Furthermore, analysis of the separation issues of L-ribose from the reaction solution and different purification methods is presented.Key points • l -Arabinose, l -ribulose and ribitol can be used to produce l -ribose by enzymes. • Five enzymes are systematically introduced for production of l -ribose. • Microbial transformation and enzymatic methods are promising for yielding l -ribose.

KEYWORDS

Biological production; Isomerase; L-Arabinose; L-Ribose; L-Ribulose

Title

Microbial and enzymatic strategies for the production of L-ribose.

Author

Chen M1, Wu H2, Zhang W1, Mu W1,3.

Publish date

2020 Apr


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