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L-Serine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L2020

  • Specification : 98%

  • CAS number : 56-45-1

  • Formula : C3H7NO3

  • Molecular Weight : 105.09

  • PUBCHEM ID : 5951

  • Volume : 20mg

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Catalogue Number

BF-L2020

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

105.09

Appearance

White crystalline powder

Botanical Source

synthesis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C(C(C(=O)O)N)O

Synonyms

L-Serin/(2R)-2-amino-3-hydroxypropanoic acid/Ser/S-serine/(S)-2-Amino-3-hydroxypropionic acid/SERINE,USP/Serine/SERINE,L/(2R)-2-Amino-3-hydroxypropionic acid/H-D-Ser-OH/L-3-Hydroxy-2-aminopropionic acid/(S)-a-Amino-b-hydroxypropionic acid/(S)-2-amino-3-hydroxypropanoic acid/Propanoic acid, 2-amino-3-hydroxy-, (S)-/H-Ser-OH/H-L-SER-OH/(S)-2-amino-3-hydroxy-Propanoic acid/2-Amino-3-hydroxypropanoic acid, (S)-/(R)-(-)-Serine/d-ser/Serine, D-/D-Serine/Serine, L-/(S)-(-)-serine/.α.-Amino-.β.-hydroxypropionic acid/L-2-Amino-3-hydroxypropionic acid/(-)-Serine/L-Serine/(R)-Serine/3-hydroxy-L-Alanine/L-Ser/b-Hydroxy-L-alanine

IUPAC Name

(2S)-2-amino-3-hydroxypropanoic acid

Density

1.6

Solubility

Water; DMSO

Flash Point

192.6±25.1 °C

Boiling Point

394.8±32.0 °C at 760 mmHg

Melting Point

222ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2922500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:56-45-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28929385

Abstract

In human neuroblastoma cell cultures, non-human primates and human beings, L-serine is neuroprotective, acting through a variety of biochemical and molecular mechanisms. Although L-serine is generally classified as a non-essential amino acid, it is probably more appropriate to term it as a “conditional non-essential amino acid” since, under certain circumstances, vertebrates cannot synthesize it in sufficient quantities to meet necessary cellular demands. L-serine is biosynthesized in the mammalian central nervous system from 3-phosphoglycerate and serves as a precursor for the synthesis of the amino acids glycine and cysteine. Physiologically, it has a variety of roles, perhaps most importantly as a phosphorylation site in proteins. Mutations in the metabolic enzymes that synthesize L-serine have been implicated in various human diseases. Dosing of animals with L-serine and human clinical trials investigating the therapeutic effects of L-serine support the FDA’s determination that L-serineis generally regarded as safe (GRAS); it also appears to be neuroprotective. We here consider the role of L-serine in neurological disorders and its potential as a therapeutic agent.

KEYWORDS

ALS; Alzheimer’s Disease; L-serine; Neurodegeneration; Neuroprotection; Therapy

Title

L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential.

Author

Metcalf JS1, Dunlop RA1, Powell JT1, Banack SA1, Cox PA2.

Publish date

2018 Jan

PMID

31344283

Abstract

L-serine is classified as a non-essential amino acid; however, L-serine is indispensable having a central role in a broad range of cellular processes. Growing evidence suggests a role for L-serine in the development of diabetes mellitus and its related complications, with L-serine being positively correlated to insulin secretion and sensitivity. L-serine metabolism is altered in type 1, type 2, and gestational diabetes, and L-serine supplementations improve glucose homeostasis and mitochondrial function, and reduce neuronal death. Additionally, L-serine lowers the incidence of autoimmune diabetes in NOD mice. Dietary supplementations of L-serine are generally regarded as safe (GRAS) by the FDA. Therefore, we believe that L-serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L-serine in diabetes.

© 2019 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology.

KEYWORDS

Deoxysphingolipids; L-serine; diabetes-related complications; type 1 diabetes; type 2 diabetes

Title

L-serine: a neglected amino acid with a potential therapeutic role in diabetes.

Author

Holm LJ1, Buschard K1.

Publish date

2019 Oct

PMID

27894192

Title

ALSUntangled 38: L-serine.

Author

ALSUntangled Group.

Publish date

2017 Feb


Description :

L-Serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.