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L-Theanine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3008

  • Specification : 98%

  • CAS number : 3081-61-6

  • Formula : C7H14N2O3

  • Molecular Weight : 174.2

  • PUBCHEM ID : 439378

  • Volume : 100mg

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Catalogue Number

BF-L3008

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

174.2

Appearance

White crystalline powder

Botanical Source

leaves of Camellia sinensis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CCNC(=O)CCC(C(=O)O)N

Synonyms

L-Theanine/THEANINE,L/(5Z)-5-(Ethylimino)-5-hydroxy-L-norvaline/Nγ-Ethyl-L-glutamine/N5-ethylglutamine/L-Glutamic acid γ-(ethylamide)/N(5)-ethyl-L-glutamine zwitterion/Theanine/(2S)-2-amino-4-(ethylcarbamoyl)butanoic acid/N-γ-ethyl-L-glutamine/L-TheaMine/L-Glutamine, N-ethyl-/SUNTHEANINE/L-Norvaline, 5-(ethylimino)-5-hydroxy-, (5Z)-/N5-Ethyl-L-glutamine/(S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid/N'-Ethyl-L-glutamine/N(5)-ethyl-L-glutamine/N-Ethyl-L-glutamine/L-γ-Glutamylethylamide

IUPAC Name

(2S)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Density

1.2±0.1 g/cm3

Solubility

Water

Flash Point

214.0±27.3 °C

Boiling Point

430.2±40.0 °C at 760 mmHg

Melting Point

207°C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2924190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:3081-61-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29037735

Abstract

l-theanine (l-Th), a non-protein amino acid present in tea, is a valuable nutraceutical product with unique health benefits and used as an additive in food industry. l-Th enhances the umami taste but its use is limited due to its inadequate production. Different extraction approaches from tea shoots, chemical synthesis to microbial transformation have been tried to meet its demand. In vitro, in vivo as well as clinical studies have shown its positive effect in regulating CNS disorders. l-Th has become choice ingredient in CNS active products due to its anti-stress and neuroprotective role in dementias particularly in retrogression of Alzheimer’s. l-Th biochemically modulates various anti-neoplastic agents by increasing their bioavailability in tumour cells. The review, is an effort to condense the recent research on l-Th highlighting its biological resource, plausible role in tea plant, production approaches, its physiological role on human health and future prospects.

KEYWORDS

Health benefits; Production approaches; Quantitation methods; Umami taste; l-Th.

Title

l-Theanine: An Astounding Sui Generis Integrant in Tea

Author

Eshita Sharma 1 , Robin Joshi 2 , Ashu Gulati 3

Publish date

2018 Mar

PMID

26192072

Abstract

Tea has been a very popular beverage around the world for centuries. The reason that it is delicious, enabling hydration, showing warming and relaxing effect can be mentioned why it is consumed so much in addition to its prominent health effects. Although the catechins and caffeine are the primary bioactive components that are related with the health effects of the tea, the health effects of theanine amino acid, which is a nonproteinic amino acid special to tea, has become prominent in recent years. It has been known that the theanine amino acid in tea has positive effects especially on relaxing, cognitive performance, emotional status, sleep quality, cancer, cardiovascular diseases, obesity, and common cold. The results of acute and chronic toxicity tests conducted on the safety of theanine express that L-theanine is reliable in general even if it is consumed too much with diet. However, it has not revealed a clear evidence-based result yet regarding theanine metabolism, health effects, and its safety. Within this frame, chemical structure of theanine, its biosynthesis, dietary sources, metabolism, health effects, and safety are discussed in present study.

KEYWORDS

Health benefits; Production approaches; Quantitation methods; Umami taste; l-Th.

Title

L-theanine, Unique Amino Acid of Tea, and Its Metabolism, Health Effects, and Safety

Author

Duygu Turkozu 1 , Nevin Sanlier 1

Publish date

2017 May 24

PMID

29629712

Abstract

BACKGROUND L-theanine is a non-protein amino acid in green tea, and its hepatoprotection and neuroprotection have been verified. However, whether L-theanine can prevent cardiomyocytes from apoptosis is unclear yet. This study evaluated the protective effects of L-theanine on H2O2-induced heart injury in vitro. MATERIAL AND METHODS The certified H9C2 cells were pretreated with L-theanine (0 mM, 4 mM, 8 mM, and 16 mM) for 24 h, followed by 160 µM H2O2 solution for 4 h. The cell viability and antioxidant indices were assayed. Quantitative evaluation of apoptosis was performed by flow cytometric analysis. Nuclear morphology of the cells was monitored by 4′,6-diamidino-2-phenylindole staining. Expression of Caspase-3, poly ADP-ribose polymerase (PARP), c-Jun N-terminal kinase (JNK), and mitogen-activated protein kinase p38 was assayed by Western blot. RESULTS Compared to the H2O2 treatment, all doses of L-theanine treatments increased the cell viability, glutathione level, and the activities of glutathione peroxidase and superoxide dismutase (P<0.001). The contents of reactive oxygen species, nitric oxide, and oxidized glutathione were decreased by L-theanine treatments (P<0.001). Meanwhile, L-theanine treatments decreased the apoptosis ratio of H2O2-induced H9C2 cells (P<0.001). Pro-Caspase-3 expression was upregulated and cleavaged-PARP expression was inhibited by L-theanine (P<0.001). However, the phosphorylation of JNK and p38 was not affected by L-theanine treatments (P>0.05). CONCLUSIONS These data indicate that L-theanine pretreatment prevents H2O2-induced apoptosis in H9C2 cells, probably via antioxidant capacity improvement. Therefore, it might be a promising potential drug candidate for prophylaxis of ischemia/reperfusion-induced heart diseases.

Title

L-Theanine Protects H9C2 Cells From Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability

Author

Chengjian Li 1 2 3 , Qiongxian Yan 1 4 , Shaoxun Tang 1 5 , Wenjun Xiao 4 , Zhiliang Tan 1 5

Publish date

2018 Apr 9


Description :

L-Theanine (L-Glutamic Acid γ-ethyl amide)is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].