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L-Threonine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L2017

  • Specification : 98%

  • CAS number : 72-19-5

  • Formula : C4H9NO3

  • Molecular Weight : 119.12

  • PUBCHEM ID : 6288

  • Volume : 20mg

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Catalogue Number

BF-L2017

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

119.12

Appearance

White needle crystal

Botanical Source

Ferment

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CC(C(C(=O)O)N)O

Synonyms

L-Tlhreonine/H-THR-OH/L-Threonine (JP15)/(2S,3R)-(-)-Threonine/L-α-Amino-β-hydroxybutyric acid/L-Threonine/2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-/H-L-THR-OH/THR/(R-(R*,S*))-2-Amino-3-hydroxybutanoic acid/L-2-Amino-3-hydroxybutyric acid/Threonine/(2S,3R)-Threonine/[R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid/(2S,3R)-2-Amino-3-hydroxybutyric acid/Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-/QY1&YZVQ &&L or (2S,3R)- Form/(s)-threonine/l-threonin/(2S,3R)-2-Amino-3-hydroxybutanoic acid/l-Thr/Threonin

IUPAC Name

(2S,3R)-2-amino-3-hydroxybutanoic acid

Density

1.3±0.1 g/cm3

Solubility

Methanol; Water

Flash Point

162.9±25.1 °C

Boiling Point

345.8±32.0 °C at 760 mmHg

Melting Point

255ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2922500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:72-19-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28357472

Abstract

Fusarium graminearum produces trichothecene mycotoxins under certain nutritional conditions. When L-Thr and its analogue L-allo-threonine were added to brown rice flour solid medium before inoculation, trichothecene production after 4 days of incubation was suppressed. A time-course analysis of gene expression demonstrated that L-Thr suppressed transcription of Tri6, a trichothecene master regulator gene, and a terpene cyclase Tri5 gene. Regulation of trichothecene biosynthesis by altering major primary metabolic processes may open up the possibility to develop safe chemicals for the reduction of mycotoxin contamination might be developed.

KEYWORDS

Amino acids; Fusarium graminearum; Mycotoxin production inhibitor; Nitrogen source; Tri gene expression

Title

L-Threonine and its analogue added to autoclaved solid medium suppress trichothecene production by Fusarium graminearum.

Author

Maeda K1, Nakajima Y1, Tanahashi Y1, Kitou Y1, Miwa A2, Kanamaru K1, Kobayashi T1, Nishiuchi T2, Kimura M3.

Publish date

2017 Aug

PMID

9404067

Abstract

An efficient production strain for L-threonine fermentation was derived from Escherichia coli by multiple rounds of mutation programs that aimed at deregulation of the L-threonine biosynthetic pathway and blocking of L-threonine degradation pathways. When the optimum amount of DL-methionine was added, this strain KY10935, an L-methionine auxotroph, gave 100 g/liter L-threonine after 77 h cultivation. In this strain, key enzymes in the L-threonine biosynthetic pathway were highly derepressed, but some were inhibited by lower concentrations of L-threonine than the accumulated level. Such incomplete deregulation of the pathway was accounted for by the intracellular concentration of L-threonine being lower than the extracellular level. In an assessment of L-threonine transport in terms of phenotypic growth responses to the amino acid, L-threonine-auxotrophic mutants with a lesion in the L-threonine operon were derived from strain KY10935 by selection for auxotrophy for dipeptide L-alanyl-L-threonine or glycyl-L-threonine, the transport systems of which were different from those of L-threonine. All three independent mutants isolated needed an extraordinarily high concentration (10 mg/ml) of L-threonine, but grew in the presence of a low concentration (10 micrograms/ml) of either dipeptide, indicating that strain KY10935 had impaired L-threonine uptake. These results suggested that the strain had an unusual mechanism of L-threonine hyperproduction: the inability to take up L-threonine that had accumulated extracellularly decreased the steady-state level of intracellular L-threonine, freeing the remaining regulatory steps of feedback inhibition.

Title

Hyperproduction of L-threonine by an Escherichia coli mutant with impaired L-threonine uptake.

Author

Okamoto K1, Kino K, Ikeda M.

Publish date

1997 Nov


Description :

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].