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L-Tryptophan

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3027

  • Specification : 98%

  • CAS number : 73-22-3

  • Formula : C11H12N2O2

  • Molecular Weight : 204.23

  • PUBCHEM ID : 6305

  • Volume : 100mg

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Catalogue Number

BF-L3027

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

204.23

Appearance

White crystalline powder

Botanical Source

Glycine max

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N

Synonyms

8,11-Dichloro-5H-dibenzo[b,e][1,4]diazepine/L(-)-Tryptophan/H-Trp-OH/Tadalafil Impurity 2

IUPAC Name

(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

Applications

L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

Density

1.4±0.1 g/cm3

Solubility

Methanol; Aqueous acid; Water

Flash Point

224.7±25.9 °C

Boiling Point

447.9±35.0 °C at 760 mmHg

Melting Point

289-290 a„ƒ (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:73-22-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

25727962

Abstract

Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of L-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1-(13)C]acetic acid and Barostat study, respectively, in rats. L-Tryptophan significantly decreased Cmax and AUC120min and delayed Tmax, indicating the inhibition of gastric emptying. L-Tryptophan significantly enhanced the gastric accommodation. These findings show that L-tryptophan may inhibit the gastric emptying through the enhanced gastric accommodation. Therefore, L-tryptophan may be useful for the therapy of postprandial dyspepsia, especially for early satiety.

Copyright © 2014 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

KEYWORDS

Gastric accommodation in rat; Gastric emptying; l-Tryptophan

Title

Effects of L-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats.

Author

Uchida M1, Kobayashi O2, Iwamoto C2.

Publish date

2015 Feb

PMID

29037509

Abstract

The eosinophilia-myalgia syndrome (EMS) outbreak of 1989 that occurred in the USA and elsewhere was caused by the ingestion of l-Tryptophan (L-Trp) solely manufactured by the Japanese company Showa Denko K.K. (SD). Six compounds present in the SD L-Trp were reported to be case-associated contaminants. However, “one” of these compounds, Peak AAA has remained structurally uncharacterized, despite the fact that it was described as “the only statistically significant (p=0.0014) contaminant”. Here, we employ on-line microcapillary-high performance liquid chromatography-electrospray ionization mass spectrometry (LC-MS), and tandem mass spectrometry (MS/MS) to determine that Peak AAA is in fact two structurally related isomers. Peak AAA1 and Peak AAA2 differed in LC retention times, and were determined by accurate mass-LC-MS to both have a protonated molecular ion (MH+) of mass 343.239Da (Da), corresponding to a molecular formula of C21H30N2O2, and possessing eight degrees of unsaturation (DoU) for the non-protonated molecule. By comparing the LC-MS and LC-MS-MS retention times and spectra with authentic synthetic standards, Peak AAA1 was identified as the intermolecular condensation product of L-Trp with anteiso 7-methylnonanoic acid, to afford (S)-2-amino-3-(2-((S,E)-7-methylnon-1-en-1-yl)-1H-indol-3-yl)propanoic acid. Peak AAA2 was determined to be a condensation product of L-Trp with decanoic acid, which produced (S)-2-amino-3-(2-((E)-dec-1-en-1-yl)-1H-indol-3-yl)propanoic acid.

Copyright © 2017 Elsevier B.V. All rights reserved.

KEYWORDS

Case-associated; Contaminants; Dietary supplements; Eosinophilia myalgia syndrome; Peak AAA

Title

Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome.

Author

Klarskov K1, Gagnon H2, Boudreault PL1, Normandin C1, Plancq B1, Marsault E1, Gleich GJ3, Naylor S4.

Publish date

2018 Jan 5