White crystalline powder
L-tyrosine zwitterion/hydrogen L-tyrosinate/MEVINOLIN/LOVALIP/a-Amino-p-hydroxyhydrocinnamic Acid/L-Phenylalanine, 4-hydroxy-/LOVASTIN/MEVACOR/H-Tyr-OH/Tyrosine/L-Tyr/Rovacor/Tyr/(S)-(-)-Tyrosine/Sivlor/L-Tyrosine/(S)-a-Amino-4-hydroxybenzenepropanoic acid/Tyrosine, L-/b-(p-Hydroxyphenyl)alanine/mevlor/Benzenepropanoic acid, α-amino-4-hydroxy-, (S)-/Tyrosinum [Latin]/(S)-a-amino-4-hydroxy-Benzenepropanoic acid/(S)-tyrosine/(S)-α-amino-4-hydroxy-Benzenepropanoic acid/msd803/Paschol
385.2±32.0 °C at 760 mmHg
>300 °C (dec.)(lit.)
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:60-18-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Electrode potentials for aromatic amino acid radical/amino acid couples were deduced from cyclic voltammograms and pulse radiolysis experiments. The amino acids investigated were l-tryptophan, l-tyrosine, N-acetyl-l-tyrosine methyl ester, N-acetyl-3-nitro-l-tyrosine ethyl ester, N-acetyl-2,3-difluoro-l-tyrosine methyl ester, and N-acetyl-2,3,5-trifluoro-l-tyrosine methyl ester. Conditional potentials were determined at pH 7.4 for all compounds listed; furthermore, Pourbaix diagrams for l-tryptophan, l-tyrosine, and N-acetyl-3-nitro-l-tyrosine ethyl ester were obtained. Electron transfer accompanied by proton transfer is reversible, as confirmed by detailed analysis of the current waves, and because the slopes of the Pourbaix diagrams obey Nernst’s law. E°'(Trp(•),H(+)/TrpH) and E°'(TyrO(•),H(+)/TyrOH) at pH 7 are 0.99 ± 0.01 and 0.97 ± 0.01 V, respectively. Pulse radiolysis studies of two dipeptides that contain both amino acids indicate a difference in E°’ of approximately 0.06 V. Thus, in small peptides, we recommend values of 1.00 and 0.96 V for E°'(Trp(•),H(+)/TrpH) and E°'(TyrO(•),H(+)/TyrOH), respectively. The electrode potential of N-acetyl-3-nitro-l-tyrosine ethyl ester is higher, while because of mesomeric stabilization of the radical, those of N-acetyl-2,3-difluoro-l-tyrosine methyl ester and N-acetyl-2,3,5-trifluoro-l-tyrosine methyl ester are lower than that of tyrosine. Given that the electrode potentials at pH 7 of E°'(Trp(•),H(+)/TrpH) and E°'(TyrO(•),H(+)/TyrOH) are nearly equal, they would be, in principle, interchangeable. Proton-coupled electron transfer pathways in proteins that use TrpH and TyrOH are thus nearly thermoneutral.
Electrode Potentials of l-Tryptophan, l-Tyrosine, 3-Nitro-l-tyrosine, 2,3-Difluoro-l-tyrosine, and 2,3,5-Trifluoro-l-tyrosine.
Mahmoudi L1, Kissner R1, Nauser T1, Koppenol WH1.
2016 May 24
A biosensor screening assay based on the synthesis of betaxanthin was applied to relatively high throughput screening of the L-tyrosine mutant library. In the assays, fluorescence output showed a linear relationship between extracellular L-tyrosine content and yellow pigment formation. In addition, the yellow pigment accumulation of the L-tyrosine high-yield strain can be easily distinguished with the naked eye compared with the wild-type strain. As a result, numerous mutants that exhibited significantly increased coloration, were screened out after random mutagenesis, and p-coumaric acid production in mutants NK-A3 and NK-B4, were remarkably improved by 4-fold more than that of the wild-type strain. In general, this study provides a novel strategy for screening mutant libraries in the search for highly L-tyrosine-producing strains.
L-tyrosine; Saccharomyces cerevisiae; betaxanthin; high-throughput screening; p-coumaric acid
A high-throughput method for screening of L-tyrosine high-yield strains by Saccharomyces cerevisiae.
Mao J1, Liu Q1, Li Y1, Yang J2, Song X2, Liu X2, Xu H2, Qiao M1,2.
2018 Sep 27
L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.