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Lauric acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-L3003

  • Specification : 98%

  • CAS number : 143-07-7

  • Formula : C12H24O2

  • Molecular Weight : 200.322

  • Volume : 100mg

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Catalogue Number

BF-L3003

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

200.322

Appearance

powder

Botanical Source

leaves of Trachycarpus fortunei

Structure Type

Others

Category

SMILES

CCCCCCCCCCCC(=O)O

Synonyms

IUPAC Name

Density

0.9±0.1 g/cm3

Solubility

DMSO : ≥ 250 mg/mL (1248.00 mM)
*"≥" means soluble, but saturation unknown.

Flash Point

134.1±11.9 °C

Boiling Point

296.1±3.0 °C at 760 mmHg

Melting Point

44-46 °C(lit.)

InChl

InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

InChl Key

POULHZVOKOAJMA-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2915900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:143-07-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32389839

Title

RIFM fragrance ingredient safety assessment, lauric acid, CAS Registry Number 143-07-7

Author

A M Api 1, D Belsito 2, S Biserta 1, D Botelho 1, M Bruze 3, G A Burton Jr 4, J Buschmann 5, M A Cancellieri 1, M L Dagli 6, M Date 1, W Dekant 7, C Deodhar 1, A D Fryer 8, S Gadhia 1, L Jones 1, K Joshi 1, A Lapczynski 1, M Lavelle 1, D C Liebler 9, M Na 1, D O'Brien 1, A Patel 1, T M Penning 10, G Ritacco 1, F Rodriguez-Ropero 1, J Romine 1, N Sadekar 1, D Salvito 1, T W Schultz 11, F Siddiqi 1, I G Sipes 12, G Sullivan 13, Y Thakkar 1, Y Tokura 14, S Tsang 1

Publish date

2020 Jul 15

PMID

32172046

Abstract

Lipase-catalyzed acylation of a hydrophilic tripeptide-KHA (TP-KHA; amino acid sequence Lys-His-Ala) with a lipophilic lauric acid was performed to produce a multi-functional compound, lauroyl tripeptide-KHA (TPL-KHA), with surface, antibacterial, and antioxidant activities. The significant acylation reaction parameters were optimized as follows: organic solvent of 2-methyl-2-butanol, reaction temperature at 55 °C, substrate molar ratio (lauric acid:TP-KHA) of 4.0, and reaction time for 72 h. Structural analyses by LC-ESI-MS and 1H NMR identified that Nε-lauroyl tripeptide-KHA was chemo-selectively synthesized by the acylation reaction under the optimum conditions. TPL-KHA showed the surface activity at the air-water interface with critical micelle concentration (CMC) of 2.71 mM and γCMC of 30.44 mN/m. TPL-KHA exhibited bacteriostatic and bactericidal effects on Gram-positive and Gram-negative foodborne pathogens (minimum inhibitory concentrations: 2.83-4.00 mM, minimum bactericidal concentrations: 3.17-5.83 mM). Moreover, it was demonstrated that TPL-KHA had the ability to scavenge ABTS+ radicals and inhibit the lipid oxidation.

KEYWORDS

Antibacterial activity; Antioxidant activity; Chemo-selectivity; Lipase-catalyzed acylation; Multi-functional food emulsifier; Surface activity.

Title

Lipase-catalyzed synthesis of lauroyl tripeptide-KHA with multi-functionalities: Its surface-active, antibacterial, and antioxidant properties

Author

Hyunjong Yu 1, Kyung-Min Park 2, Pahn-Shick Chang 3

Publish date

2020 Jul 30;

PMID

31862270

Abstract

Typically, antimicrobial peptides (AMPs) are short positive charged peptides serving a key role in innate immunity as well as antimicrobial activity. Discovering novel therapeutic agents is considered as an undeniable demand due to increasing microbial species with antibiotic resistance. In this direction, the unique ability of AMPs to modulate immune responses highlighted them as novel drug candidates in the field of microbiology. Patients affected by leishmaniasis; a neglected tropical disease, confront serious problems for their treatment including resistance to common drugs as well as toxicity and high cost of therapy. So, there is a need for development of new drug candidates to control the diseases. Jellein, a peptide derived from royal jelly of honeybee has been shown to have promising effect against several bacterial and fungal species. In current study, anti-leishmanial effect of Jellein and its lauric acid conjugated form was investigated against two forms of Leishmania major (L. major) parasite. Moreover, cytotoxic effect of these peptides was studied in THP1 cell line and human Red Blood Cells (RBCs). Furthermore, the mechanism of action of peptides on L. major promastigotes was assessed through different methods. The results demonstrated that, conjugation of lauric acid to Jellein not only had no effect on the elevation of antimicrobial activity but also halted it completely. Moreover, Jellein caused a limitation in the number of L. major promastigotes by pore formation as well as changing the membrane potential rather than induction of apoptosis or activation of caspases.

KEYWORDS

Acylation; Antimicrobial peptide; Leishmaniasis; Therapeutics.

Title

Comparative study of different forms of Jellein antimicrobial peptide on Leishmania parasite

Author

Farnaz Zahedifard 1, Hyeryon Lee 2, Joo Hwan No 2, Mona Salimi 3, Negar Seyed 4, Ahmad Asoodeh 5, Sima Rafati 6

Publish date

2020 Feb;


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