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Linderalactone

$250

  • Brand : BIOFRON

  • Catalogue Number : BF-L4010

  • Specification : 95%(HPLC)

  • CAS number : 728-61-0

  • Formula : C15H16O3

  • Molecular Weight : 244.29

  • PUBCHEM ID : 6450191

  • Volume : 25mg

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Catalogue Number

BF-L4010

Analysis Method

HPLC,NMR,MS

Specification

95%(HPLC)

Storage

-20℃

Molecular Weight

244.29

Appearance

Cryst.

Botanical Source

Lindera aggregata

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CCCC2=CC(C3=C(C1)OC=C3C)OC2=O

Synonyms

(1R)-3,8-Dimethyl-5,14-dioxatricyclo[10.2.1.0]pentadeca-2(6),3,8,12(15)-tetraen-13-one/6H-4,7-Methenofuro[3,2-c]oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R)-/(R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one/6H-4,7-Methenofuro(3,2-c)oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R,10E)-/Linderalactone

IUPAC Name

(1R,8E)-3,8-dimethyl-5,14-dioxatricyclo[10.2.1.02,6]pentadeca-2(6),3,8,12(15)-tetraen-13-one

Density

1.2±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

218.6±28.7 °C

Boiling Point

437.9±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H16O3/c1-9-4-3-5-11-7-13(18-15(11)16)14-10(2)8-17-12(14)6-9/h4,7-8,13H,3,5-6H2,1-2H3/b9-4+/t13-/m1/s1

InChl Key

LWCKQMHMTSRRAA-QGQQYVBWSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:728-61-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31128007

Abstract

PURPOSE:
The main purpose of the current research work was to evaluate the antitumor effects of linderalactone in A-549 human lung carcinoma cell line along with the study its effects on apoptosis-related proteins, cell cycle phase distribution and JAK/STAT signalling pathway.

METHODS:
The viability of lung cancer cell line was investigated by MTT assay at varying doses of linderalactone. Apoptosis was detected by using fluorescence microscopy and flow cytometry. Cell cycle analysis was carried out by flow cytometery. The protein expression was examined by western blotting.

RESULTS:
Linderalactone could inhibit the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM. Further investigations indicated the antiproliferative effects of linderalactone are due to apoptosis induction which was further confirmed by Bax and Bcl-2 expression. It also induced G2/M cell cycle arrest which was also associated with alteration of the expression of several important proteins. Furthermore, linderalactone could also suppress the JAK/STAT signalling pathway.

CONCLUSIONS:
In conclusion, linderalactone could be developed as a potential drug candidate against lung cancer provided that further in depth studies are carried out in this direction focusing on its in vivo efficacy.

Title

Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway.

Author

Deng Y1, Li Y.

Publish date

2019 Mar-Apr


Description :

Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2].