cis,cis-9,12-octadecadienoic acid/Pamolyn/9,12-Octadecadienoic acid, (9Z,12Z)-/Hidiene/cis-9,cis-12-octadecadienoic acid/Linoleic acid/LINOLEATE/emersol310/unifac6550/9-cis,12-cis-Octadecadienoic acid/IVELIP/(9Z,12Z)-9,12-Octadecadienoic acid/cis-Linoleic acid/emersol315/Linoleic/9,12-octadecadienoic acid/(9Z,12Z)-octadeca-9,12-dienoic acid
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provides coniferyl ferulate(CAS#:60-33-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Prior studies on linoleic acid, the predominant n-6 fatty acid, and breast cancer risk have generated inconsistent results. We performed a meta-analysis to summarize the evidence regarding the relationship of dietary and serum linoleic acid with breast cancer risk.
Pertinent studies were identified by a search of PubMed and EMBASE. The fixed- or random-effect pooled measure was selected based on between-study heterogeneity.
Eight prospective cohort studies and four prospective nested case-control studies, involving 10 410 breast cancer events from 358 955 adult females across different countries, were included in present study. Compared with the lowest level of linoleic acid, the pooled relative risk (RR; 95 % CI) of breast cancer was 0·98 (0·93, 1·04) for the highest level of linoleic acid. The pooled RR (95 % CI) for dietary and serum linoleic acid were 0·99 (0·92, 1·06) and 0·98 (0·88, 1·08), respectively. The RR (95 % CI) of breast cancer was 0·97 (0·91, 1·04), 0·95 (0·85, 1·07), 0·96 (0·86, 1·07), 0·98 (0·87, 1·10) and 0·99 (0·85, 1·14) for linoleic acid intake of 5, 10, 15, 20 and 25 g/d, respectively. The risk of breast cancer decreased by 1 % (RR=0·99; 95 % CI 0·93, 1·05) for every 10 g/d increment in linoleic acid intake.
This meta-analysis indicated that both dietary linoleic acid intake and serum linoleic acid level were associated with decreased risk of breast cancer, although none of the associations were statistically significant. Further investigations are warranted.
Diet; Epidemiology; Gastric cancer
Linoleic acid and breast cancer risk: a meta-analysis.
Zhou Y1, Wang T1, Zhai S1, Li W1, Meng Q1.
Whelan J1, Fritsche K.
2013 May 1
In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely tuned in a healthy brain. We also argue that subtle changes in the composition of the membrane’s fatty acids may lead to down-stream effects causing dysregulation of the membrane, cytoskeleton and their interface. Such exquisite sensitivity to minor changes is known to occur in physical systems undergoing phase transitions, the simplest and most studied of them is the so-called Ising model, which exhibits a phase transition at a finite temperature between an ordered and disordered state in 2- or 3-dimensional space. We propose this model in the context of neuronal dynamics and further hypothesize that it may involve quantum degrees of freedom dependent upon variation in membrane domains associated with ion channels or microtubules. Finally, we provide a link between these physical characteristics of the dynamical mechanism to psychiatric disorders such as major depression and antidepressant action.
Antidepressants; Cytoskeleton; Depression; Ion channels; Ising model; Linoleic acid; Lipid raft; Microtubule; Mood disorders; Quantum states
Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism.
Cocchi M1,2, Minuto C3, Tonello L4, Gabrielli F4, Bernroider G5, Tuszynski JA6,7, Cappello F8,9, Rasenick M10,11.
2017 Apr 19
Linoleic acid is a critical component of polyunsaturated fatty acids.