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Lomefloxacin hydrochloride

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1244

  • Specification : 98%(HPLC)

  • CAS number : 98079-52-8

  • Formula : C17H20ClF2N3O3

  • Molecular Weight : 387.8

  • PUBCHEM ID : 68624

  • Volume : 5mg

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Catalogue Number

BN-O1244

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

387.8

Appearance

Botanical Source

Structure Type

Category

SMILES

CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl

Synonyms

1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride/Lomefloxacin hydrochloride/Lomefloxacin (hydrochloride)

IUPAC Name

1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride

Density

Solubility

Flash Point

282ºC

Boiling Point

542.7ºC at 760 mmHg

Melting Point

290-3000C

InChl

InChl Key

KXEBLAPZMOQCKO-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:98079-52-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29782497

Abstract

Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity. The 3T3 NRU phototoxicity test (PT) in 3T3 mouse skin fibroblasts has been used to identify the phototoxic potential induced by excited chemicals after exposure to ultra violet (UV). However, as phototoxicity may occur in ocular cells, it is necessary to develop a more suitable test for cornea-derived cells. In this study, we attempted to establish a new in vitro PT method in rabbit corneal cell lines (SIRC). We evaluated five ophthalmic agents, ciprofloxacin, levofloxacin, lomefloxacin, norfloxacin, and tetracycline, for their cytotoxic potential and in vitro phototoxicity. The results obtained using 3D human corneal models revealed that the UV-induced eye tissue toxicity by the test substances showed good correlation with those obtained using the in vitro phototoxicity test. However, the results from the 3D PT for ciprofloxacin, norfloxacin, and tetracycline in the 3D human cornea model were only partially comparable. Therefore, we suggest the SIRC cell line as a new phototoxicity test model; however, a sequential testing strategy, such as 3D PT, was also proposed to obtain relevant information for topical eye agents.

Title

Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models

Author

Soyoung Kim, Writing - original draft,1,2 Ki Hwan Choi, Supervision,1 and Jaesuk Yun, Writing - review & editing2,*

Publish date

2018;


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