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Lupinalbin A

$1,216

  • Brand : BIOFRON

  • Catalogue Number : BN-O1359

  • Specification : 98%(HPLC)

  • CAS number : 98094-87-2

  • Formula : C15H8O6

  • Molecular Weight : 284.22

  • PUBCHEM ID : 5324349

  • Volume : 5mg

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Catalogue Number

BN-O1359

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

284.22

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC2=C(C=C1O)OC3=C2C(=O)C4=C(C=C(C=C4O3)O)O

Synonyms

4',5,7-trihydroxycoumaronochromone/5,7,4'-trihydroxy-coumaronochromone/1,3,8-trihydroxy-11H-[1]benzofuro[2,3-b]chromen-11-one/Lupinalbin A/11H-benzofuro[2,3-b][1]benzopyran-11-one,1,3,8-trihydroxy

IUPAC Name

1,3,8-trihydroxy-[1]benzofuro[2,3-b]chromen-11-one

Density

1.714g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

229.7ºC

Boiling Point

456.2ºC at 760 mmHg

Melting Point

InChl

InChl Key

BBBAWACESCACAP-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:98094-87-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29509670

Abstract

Apios americana, a leguminous plant, is used as food in some countries. Although the biological activities of Apios extract have been reported, there have been no reports about the anti-inflammatory mechanism of lupinalbin A on the RAW264.7 cells. In this study, we investigated the anti-inflammatory effect of A. americana lupinalbin A on lipopolysaccharide (LPS)-treated RAW264.7 cells. Lupinalbin A significantly inhibited nitric oxide production and inducible nitric oxide synthase expression in LPS-treated RAW264.7 cells. The expression of cytokines, including interleukin-6, tumor necrosis factor-α, and chemokine of monocyte chemoattractant protein, was reduced under lupinalbin A exposure in LPS-treated RAW264.7 cells. In addition, lupinalbin A significantly decreased LPS-induced interferon (IFN)-β production and STAT1 protein levels in RAW264.7 cells. Taken together, these results suggest that A. americana lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation.

KEYWORDS

Apios americana; anti-inflammatory effects; lipopolysaccharide; lupinalbin A

Title

Anti-Inflammatory Effect of Lupinalbin A Isolated from Apios americana on Lipopolysaccharide-Treated RAW264.7 Cells.

Author

Kim HY1,2, Kim JH3, So Y4, Kang SY5, Jeong HG6, Jin CH7.

Publish date

2018 Mar 6

PMID

25106881

Abstract

BACKGROUND:
Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to exhibit estrogenic and aryl hydrocarbon receptor agonistic activities in vitro and to prevent menopausal symptoms in ovariectomized Wistar rats.

METHODS:
In order to determine the major estrogen receptor α (ERα) agonists in the extract, an activity-guided fractionation was performed using the ERα yeast screen. To check whether the ERα active fractions/compounds also accounted for the aryl hydrocarbon receptor (AhR) agonistic activity of the crude methanol extract, they were further tested on the AhR yeast screen.

RESULTS:
This study led to the identification of 2′-hydroxygenistein, lupinalbin A and genistein as major estrogenic principles of the extract. 2′-hydroxygenistein and lupinalbin A were, for the first time, also shown to possess an AhR agonistic activity, whereas genistein was not active in this assay. In addition, it was possible to deduce structure-activity relationships.

CONCLUSIONS:
These results suggest that the identified compounds are the major active principles responsible for the estrogenic and AhR agonistic activities of the crude methanol extract of the aerial parts of Eriosema laurentii.

Title

Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae).

Author

Ateba SB, Njamen D, Medjakovic S, Zehl M, Kaehlig H, Jungbauer A, Krenn L1.

Publish date

2014 Aug 9


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