White crystalline powder
Schisandrachinensls（Turcz，）Baill/Myristica fragrans (nutmeg), bark of Kadsura longipedunculata and Schizandra sphenanthera
Phenol, 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-/HMS2219A18/(+)-Anwulignan/Macelignan/4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol/austrobailignan 6/Anwuligan/Macelignan, (+)-
Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.IC50 value:Target: in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell . At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min . Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected .in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice . Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions .
Methanol; Ethyl Acetate
467.0±40.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
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