We Offer Worldwide Shipping
Login Wishlist

Magnolol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-M2016

  • Specification : 98%

  • CAS number : 528-43-8

  • Formula : C18H18O2

  • Molecular Weight : 266.33

  • PUBCHEM ID : 72300

  • Volume : 20mg

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BF-M2016

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

266.33

Appearance

White crystal

Botanical Source

Siraitia grosvenorii,Valeriana jatamansi,Angelica sinensis,Cedrus deodara,Illicium difengpi

Structure Type

Lignanoids

Category

Standards;Natural Pytochemical;API

SMILES

C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

Synonyms

[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-/MAGNOLIABARKEXTRACT/DEHYDRODICHAVICOL/Honokiol std./5,5'-Diallyl-2,2'-biphenyldiol/Magnolol/[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-/1U2R DQ CR BQ E2U1/2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol/2,2'-Bichavicol/5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol/5,5'-Diallyl-2,2'-dihydroxybiphenyl/5,5′-Diallyl-2,2′-biphenyldiol/Maglol/5,5'-diallyl-biphenyl-2,2'-diol/2,2'-Dihydroxy-5,5'-diallylbiphenyl/5,5'-Diallylbiphenyl-2,2'-diol/5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol/5,5'-Di(2-propen-1-yl)-2,2'-biphenyldiol

IUPAC Name

2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol

Density

1.1±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

184.5±21.9 °C

Boiling Point

401.0±40.0 °C at 760 mmHg

Melting Point

99 - 101ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2907290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:528-43-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29925102

Abstract

Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antispastic effects. Neolignans, particularly magnolol and honokiol, are the main substances responsible for the beneficial properties of the magnolia bark extract (MBE). The content of magnolol and honokiol in MBE depends on different factors, including the Magnolia plant species, the area of origin, the part of the plant employed, and the method used to prepare the extract. The biological and pharmacological activities of magnolol and honokiol have been extensively investigated. Here we review the safety and toxicological properties of magnolol and honokiol as pure substances or as components of concentrated MBE, including the potential side-effects in humans after oral intake. In vitro and in vivo genotoxicity studies indicated that concentrated MBE has no mutagenic and genotoxic potential, while a subchronic study performed according to OECD (Organisation for Economic Co-operation and Development) guidelines established a no adverse effect level for concentrated MBE > 240 mg/kg b.w/d. Similar to other dietary polyphenols, magnolol and honokiol are subject to glucuronidation, and despite a relatively quick clearance, an interaction with pharmaceutical active principles or other herbal constituents cannot be excluded. However, intervention trials employing concentrated MBE for up to 1 y did not report adverse effects. In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe.

Georg Thieme Verlag KG Stuttgart · New York.

Title

Safety and Toxicology of Magnolol and Honokiol.

Author

Sarrica A1, Kirika N1, Romeo M2, Salmona M2, Diomede L2.

Publish date

2018 Nov

PMID

30103472

Abstract

The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

KEYWORDS

cancer; chemoresistance; magnolol; molecular targets; phytochemicals

Title

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer.

Author

Ranaware AM1, Banik K2, Deshpande V3, Padmavathi G4, Roy NK5, Sethi G6,7,8, Fan L9, Kumar AP10,11,12, Kunnumakkara AB13.

Publish date

2018 Aug 10

PMID

31240205

Abstract

Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

Title

Insights on the Multifunctional Activities of Magnolol.

Author

Zhang J1, Chen Z2, Huang X2, Shi W2, Zhang R2, Chen M3, Huang H2, Wu L2.

Publish date

2019 May 23


Description :

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.