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Mahanimbilol

$1,056

  • Brand : BIOFRON

  • Catalogue Number : BN-O0991

  • Specification : 95%(HPLC)

  • CAS number : 77156-13-9

  • Formula : C23H27NO

  • Molecular Weight : 333.47

  • PUBCHEM ID : 5353739

  • Volume : 5mg

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Catalogue Number

BN-O0991

Analysis Method

HPLC,NMR,MS

Specification

95%(HPLC)

Storage

2-8°C

Molecular Weight

333.47

Appearance

Oil

Botanical Source

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1=CC2=C(C(=C1O)CC=C(C)CCC=C(C)C)NC3=CC=CC=C32

Synonyms

1-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-methyl-9H-carbazol-2-ol

IUPAC Name

1-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-methyl-9H-carbazol-2-ol

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

280.9±26.8 °C

Boiling Point

540.8±38.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C23H27NO/c1-15(2)8-7-9-16(3)12-13-19-22-20(14-17(4)23(19)25)18-10-5-6-11-21(18)24-22/h5-6,8,10-12,14,24-25H,7,9,13H2,1-4H3/b16-12+

InChl Key

JSSIAXXILAGJKE-FOWTUZBSSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:77156-13-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28732516

Abstract

Background
The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were treated with surgery. Therefore, it might be difficult to reflect prognosis of patients treated with curative concurrent chemoradiotherapy (CCRT). Purpose of this study was to investigate clinical impact of the newly published 8-TNM compared to the current seventh TNM staging system (7-TNM) for locally advanced NSCLC patients treated with CCRT.

Methods
New 8-TNM was applied to 64 patients with locally advanced NSCLC who were treated with CCRT from 2010 to 2015. Changes in T category and stage group by 8-TNM were recorded and patterns of change were evaluated. Survival was analyzed according to T category, N category, and stage group in each staging system, respectively.

Results
Among the total of 64 patients, 38 (59.4%) patients showed change in T category while 22 (34.4%) patients showed change in stage group using 8-TNM compared to 7-TNM. Survival curves were significantly separated in the 8-TNM stage group (p = 0.001) than those in the 7-TNM (p > 0.05). Especially, survival of newly introduced stage IIIC by 8-TNM was significantly lower than that of others. On the other hand, there was no significant survival difference between T categories in each staging system.

Conclusions
Subdivision of stage III into IIIA, IIIB, and IIIC by 8-TNM for patients treated with CCRT better reflected prognosis than 7-TNM. However, subdivision of T category according to tumor size in 8-TNM might be less significant.

KEYWORDS

Non-small cell lung cancer, Staging, Chemoradiotherapy

Title

Application of the new 8th TNM staging system for non-small cell lung cancer: treated with curative concurrent chemoradiotherapy

Author

Hoon Sik Choi,#1 Bae Kwon Jeong,#2,3 Hojin Jeong,2,3 Yun Hee Lee,2,3 In Bong Ha,2 Jin Ho Song,corresponding author1,3 and Ki Mun Kangcorresponding author2,3

Publish date

2017;

PMID

28775888

Abstract

The title complex, [CuII(ClO4)(mesoPYBP)](ClO4) {PYBP = 1,1′-bis­[(pyridin-2-yl)meth­yl]-2,2′-bipiperidyl, C22H30N4}, was prepared and found to crystallize with two crystallographically independent complex salt moieties. The metal atoms of the cations adopt a pseudo-square-pyramidal coordination geometry, where the tetra­dentate amino­pyridine ligands (PYBP) are wrapped around the Cu atoms in the equatorial plane. The Cu—O bonds involving an O atom of the coordinating perchlorate anion are approximately perpendicular to the plane. The two remaining non-coordinating perchlorate anions are involved in several C—H⋯O hydrogen bonds with the PYBP ligand and balance the total charge of the complex salt. The two crystallographically independent moieties are related to each other via a pseudo-translation along the a-axis direction. Exact translational symmetry is broken by (i) a difference in the conformation of one of the piperidine rings, featuring a chair conformation in one of the cations, and a sterically disfavored boat conformation in the other; and (ii) by modulation of the non-coordinating perchlorate anions.

KEYWORDS

crystal structure, copper(II) complex, amino­pyridine

Title

{1,1′-Bis[(pyridin-2-yl)meth­yl]-2,2′-bipiperid­yl}(perchlorato)copper(II) perchlorate

Author

Guang Yang,a Elena V. Rybak-Akimova,a,* and Charles Campanab

Publish date

2017 Jul 1;

PMID

28717413

Abstract

The Tumor, Node, Metastasis (TNM) staging system, adopted by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), has been recently revised, with the new 8th edition of the staging manual being published in January 2017. This edition has few but important evidence-based changes to the TNM staging system used for lung cancer. Radiologists should be aware of the updated classification system to accurately provide staging information to oncologists and oncosurgeons. In this article, we discuss the rationale, illustrate the changes with relevance to Radiology, and review the clinical implications of the 8th edition of the UICC/AJCC TNM staging system with regards to lung cancer.

KEYWORDS

Lung, cancer; Tumor, Node, Metastasis; Staging; 8th edition

Title

Revisions to the Tumor, Node, Metastasis staging of lung cancer (8th edition): Rationale, radiologic findings and clinical implications

Author

Fernando U Kay, Asha Kandathil, Kiran Batra, Sachin S Saboo, Suhny Abbara, and Prabhakar Rajiah

Publish date

2017 Jun 28


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