Theoharn/Teoharn/2,4,6-Triamino-s-triazine/1,3,5-triazine-2,4-diamine, 1,6-dihydro-6-imino-/melamine/acetoguanamine/pluragard/2,4,6-Triamino-1,3,5-triazine,Metformin impurity D,Ph Eur)/2,4,6-Triamino-1,3,5-triazine Monomer/MelaMine MonoMer/6-Imino-1,6-dihydro-1,3,5-triazine-2,4-diamine/Cymel/hicophorpr/2,4,6-Triamino-1,3,5-triazine,sym-Triaminotriazine/cyanuramide/1,3,5-triazine-2,4,6(1H,3H,5H)-triimine/1,3,5-Triazine-2,4,6-triamine/Melamin/Aero/2,4,6-triamino-1,3,5-triazine
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provides coniferyl ferulate(CAS#:108-78-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Several studies have found that melamine causes damage to the testes, epididymis and sperm. However, few studies have investigated the effect of melamine on the synthesis of testosterone, which plays an import role in testicular development and spermatogenesis. In present study, mice were orally administrated with 2, 10 or 50mg/kg of melamine for 28days. In these groups, various abnormalities were observed including disruption of the seminiferous tubule structure, an increased necrotic germ cells and sperm abnormalities, and a reduced sperm count. Melamine exposure also decreased the level of serum testosterone and levels of testicular StAR, P450scc and 17β-HSD. In addition, melamine exposure reduced the number of Leydig cells. Taken together, these results indicate that melamine exposure reduces the level of testosterone through down-regulation of StAR and testosterone synthetic enzyme expression and also a decreased number of Leydig cells. This may further affect testicular development and lead to sperm damage.
Leydig cell; Melamine; Steroidogenesis; Testis; Testosterone.
Melamine Negatively Affects Testosterone Synthesis in Mice
Jiarui Sun 1 , Yinan Cao 1 , Xinchen Zhang 1 , Qiling Zhao 1 , Endong Bao 1 , Yingjun Lv 2
Simple and sensitive methods are required for the detection of melamine since melamine is harmful to human health. To detect the content of melamine and metal-melamine species in milk products, a new luminescent DNA silver hydrocolloid (AgNC53) was synthesized using a modified C3A-rich aptamer as the template. The emission of AgNC53 at 617 nm is sensitive to both melamine-Cu(II) and melamine, while almost no response to the free Cu(II) ion was detected. Moreover, AgNC53 is used to detect precisely the content of melamine in milk with a detection limit as low as 2.7 × 10-8 M. Thus, the AgNC53-based fluorescence method is a “label-free” fluorescence technology that can be used for the determination of melamine or the melamine-Cu(II) complex in milk products.
DNA; Fluorescent probe; Hydrocolloid; Melamine.
Determination of Melamine and melamine-Cu(II) Complexes in Milk Using a DNA-Ag Hydrocolloid as the Sensor
Wei-Yu Mu 1 , Pu-Zhen Huang 1 , Qiu-Yun Chen 2 , Wei Wang 1
Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and in vitro findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.
Cyromazine; Growth; Melamine; Neurological; Reproduction; Scoping review.
Melamine, Beyond the Kidney: A Ubiquitous Endocrine Disruptor and Neurotoxicant?
Ashley L Bolden 1 , Johanna R Rochester 2 , Carol F Kwiatkowski 3
. 2017 Oct 5