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Melatonine

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-M2005

  • Specification : 98%

  • CAS number : 73-31-4

  • Formula : C13H16N2O2

  • Molecular Weight : 232.28

  • PUBCHEM ID : 896

  • Volume : 20mg

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Catalogue Number

BF-M2005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

232.28

Appearance

White crystalline powder

Botanical Source

Juglans regia

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC

Synonyms

Melatonin/N-(2-(5-methoxyindol-3-yl)ethyl)-Acetamide/Melovine/Melatonine/primex/Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-/MLT/N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide/N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-Acetamide/N-[2-(5-methoxyindol-3-yl)ethyl]-Acetamide/N-acetyl-5-methoxytryptamine/Circadin/N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

IUPAC Name

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Density

1.2±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

231.9±31.5 °C

Boiling Point

459.8±55.0 °C at 760 mmHg

Melting Point

116.5-118 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2937900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:73-31-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32028545

Abstract

BACKGROUND/AIMS:
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords neuroprotection in rat cortical neurons subjected to oxidative stress. We here tested the hypothesis that ITH12674 could slow the retinal degeneration that causes blindness in rd10 mice, a model of retinitis pigmentosa.

METHODS:
Animals were intraperitoneally treated with 1 or 10 mg/Kg ITH12674 or placebo from P16 to P30. At P30, retinal functionality and visual acuity were analyzed by electroretinography and optomotor test. By immunohistochemistry we quantified the photoreceptor rows and analyzed their morphology and connectivity. Oxidative stress and inflammatory state was studied by Western blot, and microglia reactivity was monitored by flow cytometry. The blood-brain barrier permeation of ITH12674 was evaluated using a PAMPA-BBB assay.

RESULTS:
In rd10 mice treated with 10 mg/Kg of the compound, the following changes were observed (with respect to placebo): (i) a decrease of vision loss with higher scotopic a- and b-waves; (ii) increased visual acuity; (iii) preservation of cone photoreceptors morphology, as well as their synaptic connectivity; (iv) reduced expression of TNF-α and NF-κB; (v) increased expression of p38 MAPK and Atg12-Atg5 complex; and (vi) decreased CD11c, MHC class II and CD169 positive cell populations.

CONCLUSION:
These data support the view that a Nrf2 inducer compound may arise as a new therapeutic strategy to combat retinal neurodegeneration. At present, we are chemically optimising compound ITH12674 with the focus on improving its neuroprotective potential in retinal neurodegenerative diseases.

© Copyright by the Author(s). Published by Cell Physiol Biochem Press.

KEYWORDS

Neuroprotection; Neurodegeneration; Retina; Retinitis pigmentosa; Compound ITH12674

Title

New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10.

Author

Campello L1,2, Kutsyr O1, Noailles A1, Michalska P3,4,5, Fernandez-Sanchez L6, Martinez-Gil N1, OrtuNo-Lizaran I1, Sanchez-Saez X1, de Juan E1, Lax P1, Leon R3,4,5, Garcia AG3,4,5, Cuenca N1, Maneu V7.

Publish date

2020 Feb 7

PMID

32028434

Abstract

Cortisol is the main end product of hypothalamic-pituitary-adrenal gland (HPA axis), and melatonin (MT) has a regulating effect on HPA axis, and both are closely related to individual behavior and cognitive function. We aimed to evaluate cortisol and MT roles on children dyslexia in this study.A total of 72 dyslexic children and 72 controls were recruited in this study. Saliva samples were collected in the morning, afternoon, and night, respectively. The levels of saliva cortisol and MT were measured by enzyme-linked immunosorbent assay method. Differences of cortisol and MT levels between dyslexic and normal children were compared, and the variation trend was also analyzed by dynamic monitoring in 3 time points.The levels of salivary cortisol and MT in children with dyslexia were all lower than those in normal children whether in the morning (7:30-8:30 AM ), at afternoon (15:30-16:30 PM ) or at night (21:30-22:30 PM ) (all P < .001). Compared with normal children, the circadian rhythm variations of salivary cortisol and MT in dyslexic children disappeared and became disordered. The salivary cortisol and MT levels in children with dyslexia were declined throughout the day; and the circadian rhythm was disordered or disappeared.The results suggest that cortisol and MT levels and their circadian rhythm may affect children dyslexia, but the mechanisms need further exploration.

Title

Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia.

Author

Huang Y1, Xu C1, He M2, Huang W2, Wu K2.

Publish date

2020 Feb

PMID

31948610

Abstract

Melatonin is an indole amine that interacts with some proteins in mammals, such as calreticulin, calmodulin or sirtuins. In yeast, melatonin is synthetized and interacts with glycolytic proteins during alcoholic fermentation in Saccharomyces cerevisiae. Due to its importance as an antioxidant molecule in both Saccharomyces and non-Saccharomyces yeasts, the aim of this study was to determine the intracellular and extracellular synthesis profiles of melatonin in four non-Saccharomyces strains (Torulaspora delbrueckii, Hanseniaspora uvarum, Starmeralla bacillaris and Metschnikowia pulcherrima) and to confirm whether glycolytic enzymes can also interact with this molecule in non-conventional yeast cells. Melatonin from fermentation samples was analyzed by liquid chromatography mass spectrometry, and proteins bound to melatonin were immunopurified by melatonin-IgG-Dynabeads. Melatonin was produced in a similar pattern in all non-Saccharomyces yeast, with M. pulcherrima and S. bacillaris being the highest producers. However, melatonin only bound to proteins in two non-conventional yeasts, S. bacillaris and T. delbrueckii, which specifically had higher fermentative capacities. Sequence analysis showed that most proteins shared high levels of homology with glycolytic enzymes, but an RNA-binding protein, the elongation alpha factor, which is related to mitochondria, was also identified. This study reports for the first time the interaction of melatonin with proteins inside non-Saccharomyces yeast cells. These results reinforce the possible role of melatonin as a signal molecule, likely related to fermentation metabolism and provide a new perspective for understanding its role in yeast.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Fermentation; GADPH; Glycolysis; Melatonin; Starmerella bacillaris; Torulaspora delbrueckii

Title

Melatonin and glycolytic protein interactions are related to yeast fermentative capacity

Author

Morcillo-Parra Ma1, Gonzalez B1, Beltran G1, Mas A1, Torija MJ2.

Publish date

2020 May;


Description :

Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties.