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Methacrylamide

$52

  • Brand : BIOFRON

  • Catalogue Number : BN-O1287

  • Specification : 98%(HPLC)

  • CAS number : 79-39-0

  • Formula : C4H7NO

  • Molecular Weight : 85.1

  • PUBCHEM ID : 6595

  • Volume : 20mg

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Catalogue Number

BN-O1287

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

85.1

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(=C)C(=O)N

Synonyms

Methacrylamide/Methylacrylic amide/2-Methylpropenamide/2-Propenamide, 2-methyl-/Methacryamide/methylacrylamide/2-methylprop-2-enamide/Methacrylic acid amide/2-Propenamide,2-methyl/2-Methylacrylamide/methacrylic amide/methylbisacrylamide/2-Methyl-2-propenamide

IUPAC Name

2-methylprop-2-enamide

Density

0.9±0.1 g/cm3

Solubility

Flash Point

81.7±19.8 °C

Boiling Point

211.5±13.0 °C at 760 mmHg

Melting Point

108 °C

InChl

InChl Key

FQPSGWSUVKBHSU-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:79-39-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30183535

Abstract

OBJECTIVES:
To characterize the chemical interactions and analyze the interface of adhesive systems containing 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) and N-methacryloyl glycine (methacrylamide) functional monomers with the dentin in noncarious cervical lesions (NCCLs) compared with artificial defects (ADs).

METHODS AND MATERIALS:
Twenty human teeth with natural NCCLs on the buccal surface were used. Class V cavities, similar to NCCLs, were created on the lingual surface to serve as controls. Teeth were randomly allocated to two groups according to the functional monomer in the adhesive (N=10): G1, 10-MDP; and G2, methacrylamide. NCCLs and ADs were characterized by their mineral composition (MC) and degree of demineralization (DD) using micro-Raman spectroscopy, adhesive/dentin chemical interactions (CIs) were assessed with infrared photoacoustic spectroscopy, and interface morphology was evaluated with scanning electron and light microscopy. MC, CI, and DD data were submitted to Shapiro-Wilk and Student t-tests ( p<0.05). RESULTS: Compared with ADs, dentin in NCCLs was hypermineralized ( p<0.05). In G1, CI, and DD in the first 2 μm, and adhesive projections in NCCLs and ADs interfaces were similar. Additionally, a thin layer of dentin collagen was observed in ADs, while it was hardly present in NCCLs. In G2, although CI could not be identified, changes in the mineral components were observed. The DD in the ADs and NCCLs were statistically similar, while SEM showed a lack of adhesion at NCCLs interface. DD and collagen exposure in the ADs and NCCLs were more pronounced than in G1. CONCLUSIONS: Results suggest that the G1 adhesive could be applied directly on the superficial sclerotic layer in NCCLs. In contrast, previous cavity preparation should be conducted to improve the micromechanical interaction of G2 with the dentin.

Title

Chemical Interaction and Interface Analysis of Self-Etch Adhesives Containing 10-MDP and Methacrylamide With the Dentin in Noncarious Cervical Lesions.

Author

Oliveira B, Ubaldini A, Baesso ML, Andrade L, Lima SM, Giannini M, Hernandes L, Pascotto RC.

Publish date

2018 Sep/Oct

PMID

30183754

Abstract

Wound healing involves multiple interrelated processes required to lead to successful healing outcomes. Phagocytosis, inflammation, cell proliferation, angiogenesis, energy production, and collagen synthesis are all directly or indirectly dependent on oxygen. Along with other critical factors, such as nutrition and comorbidities, availability of oxygen is a key determinant of healing success. Previously, we have presented a novel oxygenated hydrogel material that can be made into dressings for continuous localized oxygen delivery to wounds. In this study, an acute porcine wound model was used to test the healing benefits of these oxygenated MACF (MACF + O2) hydrogel dressings compared to controls, which included commercial Derma-GelTM hydrogel dressings. Wound closure and histological analyses were performed to assess re-epithelialization, collagen synthesis, angiogenesis, and keratinocyte maturation. Results from these assays revealed that wounds treated with MACF + O2 hydrogel dressings closed faster as compared to Derma-Gel (p<0.05). Targeted metabolomics via liquid chromatography separation and mass spectrometric detection (LC-MS/MS) and a biochemical assay determined the concentration of hydroxyproline in wound samples at days 14 and 21, showing that MACF + O2 hydrogel dressings improved wound healing via an upregulated collagen synthesis pathway as compared to Derma-Gel (p<0.05). Histological evidence showed that MACF + O2 hydrogel dressings improve new blood vessel formation and keratinocyte maturation over all other treatments.

Title

Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model.

Author

Patil PS1, Evancho-Chapman MM2, Li H1, Huang H3, George RL2, Shriver LP3, Leipzig ND1.

Publish date

2018 Sep 5

PMID

28766032

Abstract

Low availability of oxygen can lead to stalled wound healing processes and chronic wounds. To address local hypoxia and to better understand direct cellular benefits, a perfluorocarbon conjugated chitosan (MACF) hydrogel that delivers oxygen was created and applied for the first time to in vitro cultures of human dermal fibroblasts and human epidermal keratinocytes under both normoxic (21% O2) and hypoxic (1% O2) environments. Results revealed that local application of MACF provided 233.8 ± 9.9 mmHg oxygen partial pressure at 2 h and maintained equilibrium oxygen levels that were approximately 17 mmHg partial pressure greater than untreated controls. Cell culture experiments showed that MACF oxygenating gels improved cellular functions involved in wound healing such as cell metabolism, total DNA synthesis and cell migration under hypoxia in both fibroblasts and keratinocytes. Adenosine triphosphate (ATP) quantification also revealed that MACF treatments improved cellular ATP levels significantly over controls under both normoxia and hypoxia (p < 0.005). In total, these studies provide new data to indicate that supplying local oxygen via MACF hydrogels under hypoxic environments improves key wound healing cellular functions.

KEYWORDS

ATP; Chitosan; Oxygen delivery; Perfluorocarbons; Wound healing

Title

Fluorinated Methacrylamide Chitosan Hydrogels Enhance Cellular Wound Healing Processes.

Author

Akula S1, Brosch IK1, Leipzig ND2.

Publish date

2017 Nov


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