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Methyl hesperidin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-M3005

  • Specification : 98%

  • CAS number : 11013-97-1

  • Formula : C29H36O15

  • Molecular Weight : 624.59

  • PUBCHEM ID : 5284419

  • Volume : 25mg

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Catalogue Number

BF-M3005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

624.59

Appearance

White needle crystal

Botanical Source

herbs of Hypericurn monogynum L.

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)OC)O)O)O)O)O)O)O

Synonyms

Methyl hesperidin/Methyl hesperidine/(2S)-2-[3,4-bis(methyloxy)phenyl]-5-hydroxy-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/(2S)-2-(3,4-Dimethoxyphenyl)-5-hydroxy-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dimethoxyphenyl)-2,3-dihydro-5-hydroxy-, (2S)-

IUPAC Name

Density

1.6±0.1 g/cm3

Solubility

Methanol; Water; DMSO

Flash Point

293.0±27.8 °C

Boiling Point

900.4±65.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2936290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:11013-97-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

8356566

Abstract

A subchronic toxicity study of methyl hesperidin was performed using B6C3F1 mice. The flavonoid was administered to groups of ten males and ten females in dietary levels of 0, 0.3, 0.6, 1.25, 2.5 and 5.0% for 13 weeks. No significant treatment-related differences were found in data for body weights, food and water consumption, hematology, clinical chemistry and organ weights. Furthermore, no effects of treatment were observed on gross and histopathological examination of the major organs. The present experiment thus demonstrated that methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.

Title

Subchronic Toxicity Study of Methyl Hesperidin in Mice

Author

M Kawabe 1 , S Tamano, M A Shibata, M Hirose, S Fukushima, N Ito

Publish date

1993 Jul

PMID

2272558

Abstract

A long-term carcinogenicity study of methyl hesperidin, a compound of the vitamin P group, was carried out in B6C3F1 mice receiving dietary concentrations of 0, 1.25 or 5%. Administration was continued for 96 wk and then the mice were maintained on basal diet for an additional 8 wk. Growth retardation during the experiment with final changes in organ weights were observed in females given the 1.25% dose of methyl hesperidin and in both sexes receiving the 5.0% treatment. However, no biologically significant effects were evident with respect to mortality or clinical signs. Furthermore, treatment with methyl hesperidin did not result in any changes in haematology, clinical chemistry and urinalysis data. On histological examination, no significant alteration of non-neoplastic and neoplastic lesion incidence was observed in treated mice. The results thus demonstrated that methyl hesperidin lacked any carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen used in this study.

Title

Carcinogenicity Study of Methyl Hesperidin in B6C3F1 Mice

Author

Y Kurata 1 , S Fukushima, A Hagiwara, H Ito, K Ogawa, N Ito

Publish date

1990 Sep

PMID

23220657

Abstract

The interaction of Methyl hesperidin (MH) with Buman serum albumin was studied by spectroscopic methods including Fluorescence quenching technology, UV absorbance spectra and Fourier transform infrared (FT-IR) spectroscopy under simulative physiological conditions. The result of fluorescence titration revealed that Methyl hesperidin could quench the intrinsic fluorescence of BSA and the quenching mechanism should be a combined quenching process. The binding constants at three temperatures (296, 303, and 310 K) were 1.82, 2.69, and 3.4 × 10(4)L mol(-1), respectively. The distance between donor (BSA) and acceptor (MH) was 5.54 nm according to the Forster theory of non-radiation energy transfer. In addition, FT-IR spectroscopy showed that the binding of MH to BSA changed the secondary structure of protein.
Copyright © 2012 Elsevier B.V. All rights reserved.

Title

Molecular Spectroscopic on Interaction Between Methyl Hesperidin and Buman Serum Albumin

Author

Jinhua Li 1 , Sumin Wang

Publish date

2013 Feb


Description :

Methyl-Hesperidin is a vasodilating agent[1].