Methyl-nonyl-keton-<2.4-dinitro-phenylhydrazon>/Methyl-n-nonylketone/undecan-2-one/4-01-00-03374/2-Oxoundecane/2-hendecanone/nonyl methyl ketone/10-undecanal/Methyl-n-nonylketon-2,4-DNPH/Undecan-2-on-<2.4-dinitro-phenylhydrazon>/2-Undecanon-2,4-dinitrophenylhydrazon/Methyl nonyl ketone/Methyl n-nonyl ketone/2-Undecanone
230.8±3.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:112-12-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Environmental Safety; Genotoxicity; Local Respiratory Toxicity; Phototoxicity/Photoallergenicity; Repeated Dose, Developmental, and Reproductive Toxicity; Skin Sensitization
RIFM fragrance ingredient safety assessment, 2-undecanone, CAS Registry Number 112-12-9.
Api AM1, Belsito D2, Botelho D1, Bruze M3, Burton GA Jr4, Buschmann J5, Dagli ML6, Date M1, Dekant W7, Deodhar C1, Francis M1, Fryer AD8, Jones L1, Joshi K1, La Cava S1, Lapczynski A1, Liebler DC9, O'Brien D1, Patel A1, Penning TM10, Ritacco G1, Romine J1, Sadekar N1, Salvito D1, Schultz TW11, Sipes IG12, Sullivan G13, Thakkar Y1, Tokura Y14, Tsang S1.
Chemosensory proteins (CSPs) play important roles in chemosensation in insects, but their exact physiological functions remain elusive. In order to investigate the functions of CSPs in the oriental armyworm Mythimna separata, in the present study we explored expression patterns and binding characteristics of the CSP, MsepCSP8. The distinctive functions of MsepCSP8 were also validated by RNAi. The results showed that MsepCSP8 shares high sequence similarity with CSPs of other insect family members, including the characteristic four-cysteine signature motif. MsepCSP8 mRNA was specifically expressed in antennae of females at levels well above those in other tissues. Competitive binding assays confirmed that 20 out of 56 ligands bound more strongly to MsepCSP8 at pH 7.4 than at pH 5.0. Protein structure modeling and molecular docking analyses identified amino acid residues involved in binding volatile compounds, and behavioral response experiments showed that M. separata elicited significant responses to five volatiles from compounds displaying high binding affinity to MsepCSP8. MsepCSP8 transcript abundance was decreased by dsMsepCSP8 injection, which affected the behavioral responses of M. separata to representative semiochemicals. Our findings demonstrate that MsepCSP8 likely contributes to mediating responses of M. separata adults to plant volatiles.
chemosensory protein, fluorescence competitive binding assay, molecular docking, behavioral response, RNAi
Functional Analysis of the Chemosensory Protein MsepCSP8 From the Oriental Armyworm Mythimna separata
Aneela Younas,1 Muhammad I. Waris,1 Muhammad Tahir ul Qamar,2 Muhammad Shaaban,3 Sean M. Prager,4 and Man-Qun Wang1,*
2018 Jul 12
Many anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar water solubility of a hydrocarbon could be used to predict receptor modulation in vitro.
GABAA (α1β2γ2s) or NMDA (NR1/NR2A) receptors were expressed in oocytes and studied using standard two-electrode voltage clamp techniques. Hydrocarbons from 14 different organic functional groups were studied at saturated concentrations, and compounds within each group differed only by the carbon number at the ω-position or within a saturated ring. An effect on GABAA or NMDA receptors was defined as a 10% or greater reversible current change from baseline that was statistically different from zero.
Hydrocarbon moieties potentiated GABAA and inhibited NMDA receptor currents with at least some members from each functional group modulating both receptor types. A water solubility cut-off for NMDA receptors occurred at 1.1 mM with a 95% CI = 0.45 to 2.8 mM. NMDA receptor cut-off effects were not well correlated with hydrocarbon chain length or molecular volume. No cut-off was observed for GABAA receptors within the solubility range of hydrocarbons studied.
Hydrocarbon modulation of NMDA receptor function exhibits a molar water solubility cut-off. Differences between unrelated receptor cut-off values suggest that the number, affinity, or efficacy of protein-hydrocarbon interactions at these sites likely differ.
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation
Robert J Brosnancorresponding author and Trung L Pham
2014 Nov 19