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Methylnonylketone

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0975

  • Specification : 98%

  • CAS number : 112-12-9

  • Volume : 0.1ml

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Catalogue Number

BD-P0975

Analysis Method

Specification

98%

Storage

2-8°C

Molecular Weight

Appearance

Botanical Source

Structure Type

Category

SMILES

CCCCCCCCCC(=O)C

Synonyms

Methyl-nonyl-keton-<2.4-dinitro-phenylhydrazon>/Methyl-n-nonylketone/undecan-2-one/4-01-00-03374/2-Oxoundecane/2-hendecanone/nonyl methyl ketone/10-undecanal/Methyl-n-nonylketon-2,4-DNPH/Undecan-2-on-<2.4-dinitro-phenylhydrazon>/2-Undecanon-2,4-dinitrophenylhydrazon/Methyl nonyl ketone/Methyl n-nonyl ketone/2-Undecanone

IUPAC Name

Applications

Density

0.8±0.1 g/cm3

Solubility

Flash Point

88.9±0.0 °C

Boiling Point

230.8±3.0 °C at 760 mmHg

Melting Point

11-13 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:112-12-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31247263

KEYWORDS

Environmental Safety; Genotoxicity; Local Respiratory Toxicity; Phototoxicity/Photoallergenicity; Repeated Dose, Developmental, and Reproductive Toxicity; Skin Sensitization

Title

RIFM fragrance ingredient safety assessment, 2-undecanone, CAS Registry Number 112-12-9.

Author

Api AM1, Belsito D2, Botelho D1, Bruze M3, Burton GA Jr4, Buschmann J5, Dagli ML6, Date M1, Dekant W7, Deodhar C1, Francis M1, Fryer AD8, Jones L1, Joshi K1, La Cava S1, Lapczynski A1, Liebler DC9, O'Brien D1, Patel A1, Penning TM10, Ritacco G1, Romine J1, Sadekar N1, Salvito D1, Schultz TW11, Sipes IG12, Sullivan G13, Thakkar Y1, Tokura Y14, Tsang S1.

Publish date

2019 Dec

PMID

30050456

Abstract

Chemosensory proteins (CSPs) play important roles in chemosensation in insects, but their exact physiological functions remain elusive. In order to investigate the functions of CSPs in the oriental armyworm Mythimna separata, in the present study we explored expression patterns and binding characteristics of the CSP, MsepCSP8. The distinctive functions of MsepCSP8 were also validated by RNAi. The results showed that MsepCSP8 shares high sequence similarity with CSPs of other insect family members, including the characteristic four-cysteine signature motif. MsepCSP8 mRNA was specifically expressed in antennae of females at levels well above those in other tissues. Competitive binding assays confirmed that 20 out of 56 ligands bound more strongly to MsepCSP8 at pH 7.4 than at pH 5.0. Protein structure modeling and molecular docking analyses identified amino acid residues involved in binding volatile compounds, and behavioral response experiments showed that M. separata elicited significant responses to five volatiles from compounds displaying high binding affinity to MsepCSP8. MsepCSP8 transcript abundance was decreased by dsMsepCSP8 injection, which affected the behavioral responses of M. separata to representative semiochemicals. Our findings demonstrate that MsepCSP8 likely contributes to mediating responses of M. separata adults to plant volatiles.

KEYWORDS

chemosensory protein, fluorescence competitive binding assay, molecular docking, behavioral response, RNAi

Title

Functional Analysis of the Chemosensory Protein MsepCSP8 From the Oriental Armyworm Mythimna separata

Author

Aneela Younas,1 Muhammad I. Waris,1 Muhammad Tahir ul Qamar,2 Muhammad Shaaban,3 Sean M. Prager,4 and Man-Qun Wang1,*

Publish date

2018 Jul 12

PMID

25410726

Abstract

Background
Many anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar water solubility of a hydrocarbon could be used to predict receptor modulation in vitro.

Methods
GABAA (α1β2γ2s) or NMDA (NR1/NR2A) receptors were expressed in oocytes and studied using standard two-electrode voltage clamp techniques. Hydrocarbons from 14 different organic functional groups were studied at saturated concentrations, and compounds within each group differed only by the carbon number at the ω-position or within a saturated ring. An effect on GABAA or NMDA receptors was defined as a 10% or greater reversible current change from baseline that was statistically different from zero.

Results
Hydrocarbon moieties potentiated GABAA and inhibited NMDA receptor currents with at least some members from each functional group modulating both receptor types. A water solubility cut-off for NMDA receptors occurred at 1.1 mM with a 95% CI = 0.45 to 2.8 mM. NMDA receptor cut-off effects were not well correlated with hydrocarbon chain length or molecular volume. No cut-off was observed for GABAA receptors within the solubility range of hydrocarbons studied.

Conclusions
Hydrocarbon modulation of NMDA receptor function exhibits a molar water solubility cut-off. Differences between unrelated receptor cut-off values suggest that the number, affinity, or efficacy of protein-hydrocarbon interactions at these sites likely differ.

Title

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation

Author

Robert J Brosnancorresponding author and Trung L Pham

Publish date

2014 Nov 19