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Minoxidil

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-M2010

  • Specification : 98%

  • CAS number : 38304-91-5

  • Formula : C9H15N5O

  • Molecular Weight : 209.25

  • PUBCHEM ID : 4201

  • Volume : 20mg

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Catalogue Number

BF-M2010

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

209.25

Appearance

Powder

Botanical Source

synthesis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O

Synonyms

Regaine/2,4-diamino-6-piperidino-pyrimidine-3-oxide/2,6-Diamino-4-piperidinopyrimidine 1-Oxide/Rogaine/4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-, (2E)-/Theroxidil/3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine/Tricoxidil/6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide/Lonolox/(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol/6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide/2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide/Alostil/Loniten/Minoximen

IUPAC Name

3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine

Density

1.5±0.1 g/cm3

Solubility

Flash Point

166.5±28.7 °C

Boiling Point

351.7±45.0 °C at 760 mmHg

Melting Point

272-274 °C (dec.)(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933590000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:38304-91-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30246901

Title

Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability & the Five C's of Oral Therapy

Author

Renee A Beach 1

Publish date

2018 Nov;3

PMID

31172981

Title

Author's Reply

Author

Samaneh Mozafarpoor 1

Publish date

Jul-Aug 2019

PMID

28796428

Title

Topical Cetirizine 1% for Treatment of Androgenetic Alopecia

Author

Ayman Abdelmaksoud 1

Publish date

2017 Nov


Description :

Minoxidil(U 10858) is an antihypertensive vasodilator medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The pharmacologic mechanisms by which minoxidil stimulates hair growth are unknown. This study was designed to examine whether minoxidil has direct effects on neonatal murine epidermal cells in culture. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation. In addition, two morphologically distinct cell types appeared. Indirect immunofluorescence staining with keratin-specific antibody revealed cytoplasmic keratin fibers, suggesting the epidermal origin of these cells. Our experiments demonstrate that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance [1] . Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h [2].