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*"≥" means soluble, but saturation unknown.
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provides coniferyl ferulate(CAS#:70476-82-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
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disability; efficacy; mitoxantrone; relapsing-remitting multiple sclerosis; secondary progressive multiple sclerosis.
Is there a new place for mitoxantrone in the treatment of multiple sclerosis?
Sławomir Wawrzyniak 1, Łukasz Rzepiński 2
Background: Cell adhesion-mediated drug resistance (CAM-DR) is a major clinical problem that prevents successful treatment of multiple myeloma (MM). In particular, the expression levels of integrin β1 and its sub-cellular distribution (internalization and trafficking) are strongly associated with CAM-DR development.
Methods: Development of an adhesion model of established MM cell lines and detection of Numbl and Integrinβ1 expression by Western Blot analysis. The interaction between Numbl and Integrinβ1 was assessed by a co-immunoprecipitation (CO-IP) method. Calcein AM assay was performed to investigate the levels of cell adhesion. Finally, the extent of CAM-DR in myeloma cells was measured using cell viability assay and flow cytometry analysis.
Results: Our preliminary date suggest that Numbl is differentially expressed in a cell adhesion model of MM cell lines. In addition to binding to the phosphotyrosine-binding (PTB) domain, the carboxyl terminal of Numbl can also interact with integrin β1 to regulate the cell cycle by activating the pro-survival PI3K/AKT signaling pathway. This study intends to verify and elucidate the interaction between Numbl and integrin β1 and its functional outcome on CAM-DR. We have designed and developed a CAM-DR model using MM cells coated with either fibronectin or bone marrow stromal cells. We assessed whether Numbl influences cell-cycle progression and whether it, in turn, contributes to activation of PI3K/AKT signal pathway through the adjustment of its carboxyl end. Finally, we showed that the interaction of Numbl with integrin β1 promotes the formation of CAM-DR in MM cells.
Conclusions: Our findings elucidated the specific molecular mechanisms of CAM-DR induction and confirmed that Numbl is crucial for the development of CAM-DR in MM cells.
Integrin β1, CAM-DR; MM; Numbl.
Elucidating the expression and function of Numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM)
Yuejiao Huang 1, Xianting Huang 2, Chun Cheng 3, Xiaohong Xu 1, Hong Liu 4, Xiaojing Yang 3, Li Yao 5, Zongmei Ding 3, Jie Tang 3, Song He 6, Yuchan Wang 7
2019 Dec 30;
Anti-tumor drugs, due to their non-specific toxicity will cause long-term delayed toxicity to organisms and humans when discharged into the environment. In this study, reduced graphene oxide @ iron nanoparticles (rGO@Fe NPs) were successfully prepared using green tea extract as reductant and subsequently used for mitoxantrone (MTX) removal. SEM and Raman spectroscopy showed that 30-60 nm sized Fe NPs were loaded on rGO and green tea extract successfully reduced GO to rGO. The removal efficiency of MTX by the hybrid material was higher (98.5%) than either rGO (77.5%) or Fe NPs (53.1%) alone. In addition, the removal efficiency of MTX by the hybrid material was as high as 95% within 5 min, MTX adsorption followed both a pseudo-second-order kinetic model and the Langmuir isotherm, and it is a spontaneous adsorption. Recycling experiments showed that the removal efficiency of MTX decreased from 99.9 to 76.8% after six cycles, and could be as high as 99% in both municipal and medical wastewater. Scanning electron microscopy (SEM), Fourier transform infrared Spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and High performance liquid chromatography (HPLC) were all used to characterize and analyze the hybrid material, and possible adsorption mechanisms which revealed that MTX adsorption probably involved a combination of π-π stacking interaction, hydrogen bonding, electrostatic interaction and pore-filling.
Green synthesized; Mitoxantrone; Removal mechanism; rGO@Fe NPs.
Removal mechanism of mitoxantrone by a green synthesized hybrid reduced graphene oxide @ iron nanoparticles
Jing Wu 1, Ze Lin 1, Xiulan Weng 1, Gary Owens 2, Zuliang Chen 3