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Mitraphylline

$364

  • Brand : BIOFRON

  • Catalogue Number : BD-P0845

  • Specification : 98.0%(HPLC)

  • CAS number : 509-80-8

  • Formula : C21H24N2O4

  • Molecular Weight : 368.433

  • PUBCHEM ID : 94160

  • Volume : 25mg

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Catalogue Number

BD-P0845

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

368.433

Appearance

Powder

Botanical Source

Uncariae Ramulus cum Uncis

Structure Type

Indoles

Category

SMILES

CC1C2CN3CCC4(C3CC2C(=CO1)C(=O)OC)C5=CC=CC=C5NC4=O

Synonyms

methyl (1S,4aS,5aS,6R,10aR)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate

IUPAC Name

methyl (1S,4aS,5aS,6R,10aR)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate

Applications

Density

1.33 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

289.6ºC

Boiling Point

555.2ºC

Melting Point

InChl

InChI=1S/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14+,18-,21+/m0/s1

InChl Key

JMIAZDVHNCCPDM-DAFCLMLCSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:509-80-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31510078

Abstract

Uncaria tomentosa (Rubiaceae) has a recognized therapeutic potential against various diseases associated with oxidative stress. The aim of this research was to evaluate the antioxidant potential of an aqueous leaf extract (ALE) from U. tomentosa, and its major alkaloids mitraphylline and isomitraphylline. The antioxidant activity of ALE was investigated in vitro using standard assays (DPPH, ABTS and FRAP), while the in vivo activity and mode of action were studied using Caenorhabditis elegans as a model organism. The purified alkaloids did not exhibit antioxidant effects in vivo. ALE reduced the accumulation of reactive oxygen species (ROS) in wild-type worms, and was able to rescue the worms from a lethal dose of the pro-oxidant juglone. The ALE treatment led to a decreased expression of the oxidative stress response related genes sod-3, gst-4, and hsp-16.2. The treatment of mutant worms lacking the DAF-16 transcription factor with ALE resulted in a significant reduction of ROS levels. Contrarily, the extract had a pro-oxidant effect in the worms lacking the SKN-1 transcription factor. Our results suggest that the antioxidant activity of ALE in C. elegans is independent of its alkaloid content, and that SKN-1 is required for ALE-mediated stress resistance.

KEYWORDS

Uncaria tomentosa, Caenorhabditis elegans, antioxidants, oxidative stress, mitraphylline, isomitraphylline

Title

Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans

Author

Bruna C. Azevedo,1,2,3 Mariana Roxo,3 Marcos C. Borges,2 Herbenya Peixoto,3 Eduardo J. Crevelin,4 Bianca W. Bertoni,1 Silvia H. T. Contini,1 Adriana A. Lopes,1 Suzelei C. Franca,1 Ana M. S. Pereira,1 and Michael Wink3,*

Publish date

2019 Sep

PMID

28801652

Abstract

Essential tremor (ET) is the most common tremor disorder. Evidences indicated that genetics plays an essential role in the researches of etiology. A new genome-wide association study (GWAS) from European population identified three novel loci in ET, which were rs10937625 in STK32B, rs17590046 in PPARGC1A, and rs12764057, rs10822974 and rs7903491 in CTNNA3. Due to the different genetic background in different population, we performed a case-control study to investigate these variants in a cohort of 533 subjects in Chinese population. We found a significant difference in the distributions of genotypes and alleles frequencies between ET and control groups of rs10937625 (genotype p = 0.037, OR = 0.69[0.48-0.98]; allele p = 0.033, OR = 0.82[0.69-0.99]) and rs7903491 (genotype p = 0.030, OR = 1.34[1.03-1.74]; allele p = 0.029, OR = 1.16[1.02-1.32]) after adjusted for age and gender. And no associations were detected between rs17590046 (genotype p = 0.794; allele p = 0.791), rs12764057 (genotype p = 0.337; allele p = 0.337), rs10822974 (genotype p = 0.102; allele p = 0.100) and ET in Chinese population individually. Our research supports that C allele of rs10937625 in STK32B is a protective factor and G allele of rs7903491 in CTNNA3 is a risk factor for ET in Chinese population.

Title

Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population

Author

Yuan Zhang,1 Yuwen Zhao,1 Xiaoting Zhou,1 Kai Li,1 Minhan Yi,3,4 Jifeng Guo,1,3,5,6 Xinxiang Yan,1,5,6 Beisha Tang,1,3,5,6 and Qiying Suncorresponding author2,5,6

Publish date

2017