We Offer Worldwide Shipping
Login Wishlist

Miyabenol C

$1,152

  • Brand : BIOFRON

  • Catalogue Number : BN-O1327

  • Specification : 98%(HPLC)

  • CAS number : 109605-83-6

  • Formula : C42H32O9

  • Molecular Weight : 680.7

  • PUBCHEM ID : 6475924

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1327

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

680.7

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC(=CC=C1C=CC2=C3C(C(OC3=CC(=C2)O)C4=CC=C(C=C4)O)C5=CC6=C(C(=C5)O)OC(C6C7=CC(=CC(=C7)O)O)C8=CC=C(C=C8)O)O

Synonyms

E-cis-miyabenol C/(+)-trans-miyabenol C/Z-miyabenol C

IUPAC Name

5-[(2R,3R)-6-hydroxy-4-[(2S,3S)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

RKFYYCKIHVEWHX-YOBICRQBSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:109605-83-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25629409

Abstract

Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimer’s disease (AD). Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase. Inhibiting β-secretase activity is believed to be one of the most promising strategies for AD treatment. In the present study, we found that a resveratrol trimer, miyabenol C, isolated from stems and leaves of the small-leaf grape (Vitisthunbergii var. taiwaniana), can markedly reduce Aβ and sAPPβ levels in both cell cultures and the brain of AD model mice. Mechanistic studies revealed that miyabenol C affects neither protein levels of APP, the two major α-secretases ADAM10 and TACE, and the γ-secretase component Presenilin 1, nor γ-secretase-mediated Notch processing and TACE activity. In contrast, although miyabenol C has no effect on altering protein levels of the β-secretase BACE1, it can inhibit both in vitro and in vivo β-secretase activity. Together, our results indicate that miyabenol C is a prominent β-secretase inhibitor and lead compound for AD drug development.

Title

The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation.

Author

Hu J1, Lin T2, Gao Y3, Xu J2, Jiang C2, Wang G2, Bu G3, Xu H1, Chen H2, Zhang YW3.

Publish date

2015 Jan 28

PMID

12518232

Abstract

o examine the binding sites of miyabenol C (Miy C) and kobophenol A ( Kob A) with estrogen receptor (ER), computer modeling was applied to determine 3D structure of Miy C and Kob A. Molecular docking of the components to ER was carried out to find the binding sites between them. PCR mutagenesis was used to change the structure of ER cDNA. After the mutated sites were confirmed by DNA sequencing, report gene assay was used to study the effects of Miy C and Kob A on the trans-activating ability of ER. Results indicated that the effect of Miy C on the trans-activating ability of mutant 1 of ER [M1ER (ER M(517)AG(521)D)] was decreased, and Kob A had no stimulating effects on the trans-activating ability of M1ER. Miy C and Kob A had no stimulating effects on the trans-activating ability of mutant 2 of ER [M2ER (ER E(353)GR(394)G)]. Therefore, the ER sites for Miy C and Kob A may be located at Glu(353), Arg(394), Met(517) and Gly(521).

Title

[The binding sites of estrogen receptor for miyabenol C and kobophenol A].

Author

Tian CY1, Gao HD, Zhang YG, Xu G, Hu CQ, Song HY.

Publish date

2003 Jan


Description :

Empty ...