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Mogroside II-A2

$1,120

  • Brand : BIOFRON

  • Catalogue Number : BD-P0785

  • Specification : 98.0%(HPLC)

  • CAS number : 88901-45-5

  • Formula : C42H72O14

  • Molecular Weight : 801

  • PUBCHEM ID : 102594495

  • Volume : 25mg

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Catalogue Number

BD-P0785

Analysis Method

Specification

98.0%(HPLC)

Storage

-20℃

Molecular Weight

801

Appearance

Powder

Botanical Source

This product is isolated and purified from the fruits of Siraitia grosvenorii Swingle.

Structure Type

Category

SMILES

CC(CCC(C(C)(C)O)O)C1CCC2(C1(CC(C3(C2CC=C4C3CCC(C4(C)C)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)O)O)C)O)C)C

Synonyms

(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R)-6-[[(3S,9R,11R,13R,14S)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-11-hydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

IUPAC Name

Applications

IOSR Journal of Pharmacy,2015,5(10):48-53. Complete NMR Assignment of MogrosidesII A2, II E andIII A1Isolated from Luo Han Guo[Reference: WebLink]NMR analysis allowed complete assignments of three known mogrol glycosides, Mogroside II-A2 (1), Mogroside II E (2)and Mogroside III-A1 (3), isolated from the extracts of Luo Han Guo. METHODS AND RESULTS: Herein, complete 1 H and 13 C NMR assignmentsof all threemogrosidesare described based on NMR experiments ( 1 H NMR, 13 C NMR, COSY, HSQC-DEPT, HMBC, NOESY and 1DTOCSY) and mass spectral data.

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

506.7±34.3 °C

Boiling Point

914.2±65.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

SLAWMGMTBGDBFT-UMIXZHIDSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:88901-45-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30754652

Abstract

Mogrosides, the main bioactive compounds isolated from the fruits of Siraitia grosvenorii, are a group of cucurbitane-type triterpenoid glycosides that exhibit a wide range of notable biological activities and are commercially available worldwide as natural sweeteners. However, the extraction cost is high due to their relatively low contents in plants. Therefore, molecular breeding needs to be achieved when conventional plant breeding can hardly improve the quality so far. In this study, the levels of 21 active mogrosides and two precursors in 15 S. grosvenorii varieties were determined by HPLC-MS/MS and GC-MS, respectively. The results showed that the variations in mogroside V content may be caused by the accumulation of cucurbitadienol. Furthermore, a total of four wild-type cucurbitadienol synthase protein variants (50R573L, 50C573L, 50R573Q, and 50C573Q) based on two missense mutation single nucleotide polymorphism (SNP) sites were discovered. An in vitro enzyme reaction analysis indicated that 50R573L had the highest activity, with a specific activity of 10.24 nmol min−1 mg−1. In addition, a site-directed mutant, namely, 50K573L, showed a 33% enhancement of catalytic efficiency compared to wild-type 50R573L. Our findings identify a novel cucurbitadienol synthase allele correlates with high catalytic efficiency. These results are valuable for the molecular breeding of luohanguo.

KEYWORDS

Siraitia grosvenorii, molecular breeding, site-directed mutant, mogrosides, cucurbitadienol synthase, single nucleotide polymorphism (SNP)

Title

Identification of a Novel Specific Cucurbitadienol Synthase Allele in Siraitia grosvenorii Correlates with High Catalytic Efficiency

Author

Jing Qiao,1 Zuliang Luo,1 Zhe Gu,1 Yanling Zhang,2 Xindan Zhang,2 and Xiaojun Ma1,*

Publish date

2019 Feb