Yellow crystalline powder
Norartocarpin/2-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-8-((Z)-3-methyl-but-2-enyl)-3-(3-methyl-but-2-enyl)-1-benzopyran-4-one/2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)-4H-chromen-4-one/4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-buten-1-yl)-/Kuwanon C
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.
657.7±55.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:62949-79-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Abnormal neuroinflammation and oxidative stress has been shown to cause neuronal loss in the progressive neurodegenerative Parkinson’s disease (PD). Mulberrin is the key component of Ramulus Mori that has various biological activities. This study was to investigate the functions and mechanisms of mulberrin in PD. PD models were established by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Sprague Dawley rats in vivo and Lipopolysaccharide (LPS) treatment on microglial BV2 cells in vitro. Rota-rod test was applied to investigate the roles of mulberrin on MPTP-induced behavioral impairment. The effects of mulberrin on neuronal number and microglia activation were assessed by tyrosine hydroxylase (TH) immunohistochemistry and ionized calcium binding adaptor molecule-1 (Iba-1) immunofluorescence. Inflammatory cytokines and oxidative markers were measured by qRT-PCR. Wnt/β-catenin components were compared by Western blot. Mulberrin alleviated MPTP-induced impairment of motor coordination in a dose-dependent manner, and partially restored neuronal and microglial population. Neuroinflammation and oxidative stress were suppressed after mulberrin treatment both in vivo and in vitro. Wnt/β-catenin pathway was partially restored in BV2 cells. Finally, mulberrin rescued MPTP-induced abnormality in tracer elimination by MRI. Our study indicates that mulberrin is a potent suppressor of PD abnormalities and warrants further investigations in the clinical application of mulberrin for treating PD.
Copyright © 2019 Elsevier B.V. All rights reserved.
Inflammation; Mulberrin; Oxidative stress; Parkinson’s disease; Wnt/β-catenin signaling pathway
Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson's disease by promoting Wnt/β-catenin signaling pathway.
Cao W1, Dong Y2, Zhao W3, Lu X4, Sun L5.
Spinal cord injury (SCI) is a major reason of paralysis, disability and even death in severe cases. Mulberrin (Mul) is a major compound of ramulus mori and turned out that it has potent ability on tyrosinase inhibition. Ramulus mori has been reported to possess anti-inflammation, anti-oxidative stress and anti-apoptosis effects. However, the effects of Mul on SCI progression and the underlying molecular mechanism have never been elucidated before. Here, we established a SCI rat model, which subsequently received Mul treatment. The findings showed that Mul treatment improved the functional recovery of SCI rats, along with reduced spinal cord water contents and myeloperoxidase (MPO) activity. SCI-induced apoptosis was attenuated by Mul, as evidenced by the reduced TUNEL-positive cells, and the decreased pro-apoptotic signals expressions, while increased anti-apoptotic molecule. Further, Mul inhibited inflammatory response in the spinal cord tissues of SCI rats through inactivating nuclear factor-kappa B (NF-κB) pathway. Oxidative stress was also decreased by Mul treatment in SCI mice, associated with the up-regulation of heme oxygenase-1 (HO-1)/nuclear factor E2-related factor 2 (HO-1/Nrf-2) pathway. Significantly, SCI rats showed high expression of miR-337 in spinal cord tissue samples. Astrocytes (AST) stimulated by LPS also had higher expression of miR-337. Nrf-2 was found to be a direct target for miR-337. Over-expressing miR-337 markedly reduced Nrf-2 expression in AST, whereas inhibiting miR-337, Nrf-2 expressions were significantly increased. In vitro, AST transfected with miR-337 inhibitor showed attenuated inflammation, apoptosis and oxidative stress in LPS-treated AST, which was, intriguingly, abolished by Nrf-2 knockdown. Together, the findings above indicated that Mul could attenuate SCI by reducing miR-337 expressions to reduce apoptosis, inflammation and oxidative stress via regulating Nrf-2.
Copyright © 2018. Published by Elsevier Masson SAS.
Mulberrin (Mul); Nrf-2; Spinal cord injury (SCI); miR-337
Mulberrin (Mul) reduces spinal cord injury (SCI)-induced apoptosis, inflammation and oxidative stress in rats via miroRNA-337 by targeting Nrf-2.
Xia P1, Gao X2, Duan L2, Zhang W1, Sun YF3.