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Muscone

$60

  • Brand : BIOFRON

  • Catalogue Number : AV-P11471

  • Specification : 98%

  • CAS number : 541-91-3

  • Formula : C16H30O

  • Molecular Weight : 238.41

  • PUBCHEM ID : 10947

  • Volume : 0.1ml

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Catalogue Number

AV-P11471

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

238.41

Appearance

Colorless transparent oily liquid

Botanical Source

Moschus

Structure Type

Aliphatic Compounds

Category

Standards;Natural Pytochemical;API

SMILES

CC1CCCCCCCCCCCCC(=O)C1

Synonyms

Musk/Cyclopentadecanone, 3-methyl-/3-Methylcyclopentadecanone/Muskone/DL-MUSCONE/dl-Muscone or 3-Methylcyclopentadecanone/Musk Ketone/moschusketone/MUSCONE/MUSCONE II

IUPAC Name

3-methylcyclopentadecan-1-one

Applications

Density

0.8±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

145.3±11.3 °C

Boiling Point

329.5±10.0 °C at 760 mmHg

Melting Point

33ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:541-91-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30662666

Abstract

Muscone is the main active monomer of traditional Chinese medicine musk. Previous studies have reported a variety of beneficial effects of muscone. However, the effects of muscone on chronic inflammation after myocardial infarction (MI) are rarely reported. This study evaluated the anti-inflammatory effects of muscone on myocardial infarction by establishing a MI model in mice. We found that muscone remarkably decreased the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improved cardiac function and survival rate. Furthermore, the main anti-inflammatory effect of muscone was alleviating cardiac macrophage-mediated inflammatory response in heart tissues after MI. Bone marrow-derived macrophages (BMDMs) induced with lipopolysaccharide (LPS) were used as an in vitro inflammation model to further clarify anti-inflammatory mechanisms of muscone. Muscone significantly downregulated the levels of LPS-induced inflammatory cytokines and inhibited NF-κB and NLRP3 inflammasome activation in BMDMs. Moreover, ROS and antioxidant indices in LPS-induced BMDMs were also ameliorated after muscone treatment. To sum up, our study found that muscone alleviated cardiac macrophage-mediated chronic inflammation by inhibiting NF-κB and NLRP3 inflammasome activation, thereby improving cardiac function in MI mice. Besides, the inhibitory effect of muscone on inflammation may be related to the scavenging of ROS. It is suggested that muscone may serve as a promising and effective drug for post-MI treatment.

KEYWORDS

Muscone; NF-κB; NLRP3 inflammasome; anti-inflammation; macrophage; myocardial infarction

Title

Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.

Author

Du Y1, Gu X1, Meng H1, Aa N1, Liu S1, Peng C1, Ge Y2, Yang Z1.

Publish date

2018 Dec 15

PMID

29136757

Abstract

Long-term alcohol abuse causes musculoskeletal disorders, among of which, alcohol-induced osteonecrosis of the femoral head (ONFH) is of concern due to its significant and severe complications. A variety of methods have been attempted to prevent alcohol-induced ONFH, and monomers extracted from Chinese herbs might benefit the disease profoundly. In the current study, muscone, the main ingredient of musk, was used to prevent alcohol-induced ONFH. In vitro, ethanol was used to affect the potential of osteogenesis and proliferation of human bone mesenchymal stem cells (hBMSCs), and beneficial role of muscone was investigated on hBMSCs. In vivo, following the establishment of alcohol-induced ONFH, muscone was employed to treat the diseased rats, which were analyzed by micro-CT scanning and a series of histologic staining. As a result, we found ethanol could significantly suppress osteogenic differentiation of hBMSCs, while muscone held the potential to promote ALP activity and mRNA expressions of COL1 and OCN under ethanol treatment. Meanwhile, imaging analysis revealed muscone could restore BV/TV ratio and bone mineral density of the necrotic femoral head, and the protective role of muscone on alcohol-induced ONFH was further confirmed by histologic examinations. Our study confirmed the protective effect of muscone against alcohol-induced ONFH both in vitro and in vivo. Therefore, muscone may be considered as a valuable therapeutic natural drug for alcohol-induced ONFH in humans.

Copyright ? 2017 Elsevier Masson SAS. All rights reserved.

KEYWORDS

Alcohol; Human bone mesenchymal stem cells; Muscone; Osteonecrosis of the femoral head

Title

Muscone exerts protective roles on alcohol-induced osteonecrosis of the femoral head.

Author

Guo YJ1, Luo SH2, Tang MJ1, Zhou ZB3, Yin JH4, Gao YS5, Dang XQ6.

Publish date

2018 Jan

PMID

32265718

Abstract

Postmenopausal osteoporosis is caused by the deficiency of estrogen, which breaks bone homeostasis and induces levels of pro-inflammatory cytokines. Muscone is a potent anti-inflammatory agent and is used to treat bone fracture in traditional Chinese medicine. However, its anti-osteoclastogenic effects remain unclear. For in vitro study, morphology tests of osteoclastogenesis were firstly performed. And then, factors in RANK-induced NF-κB and MAPK pathways were examined by RT-PCR and Western blot, and the binding of TNF receptor-associated factor (TRAF)6 to RANK was inspected by coimmunoprecipitation and immunofluorescence staining. For in vivo experiments, C57BL/6 ovariectomized (OVX) mice were used for detection, including H&E staining, TRAP staining, and micro CT. As a result, muscone reduced OVX-induced bone loss in mice and osteoclast differentiation in vitro, by inhibiting TRAF6 binding to RANK, and then suppressed NF-κB and MAPK signaling pathways. The expression of the downstream biomarkers was finally inhibited, including NFATc1, CTR, TRAP, cathepsin K, and MMP-9. The inflammatory factors, TNF-a and IL-6, were also reduced by muscone. Taken together, muscone inhibited the binding of TRAF6 to RANK induced by RANKL, thus blocking NF-kB and MAPK pathways, and down-regulating related gene expression. Finally, muscone inhibited osteoclastogenesis and osteoclast function by blocking RANK-TRAF6 binding, as well as downstream signaling pathways in vitro. Muscone also reduced ovariectomy-induced bone loss in vivo.

Copyright ? 2020 Zhai, Yan, Zhao, Chen, Yang, Cai, He, Huang, Li, Yang, Zhou, Zhao, Wei, Bai and Li.

KEYWORDS

RANK; TRAF6; muscone; osteoclasts; postmenopausal osteoporosis

Title

Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor-Associated Factor 6-Mediated Signaling Pathways.

Author

Zhai X1, Yan Z2, Zhao J1, Chen K1, Yang Y1, Cai M2, He C2, Huang C2, Li B1, Yang M1, Zhou X1, Zhao Y1, Wei X1, Bai Y1, Li M1.

Publish date

2020 Mar 20