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Myristic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-M3015

  • Specification : 98%

  • CAS number : 544-63-8

  • Formula : C14H28O2

  • Molecular Weight : 228.37

  • PUBCHEM ID : 11005

  • Volume : 100mg

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Catalogue Number

BF-M3015

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

228.37

Appearance

White needle crystal

Botanical Source

Angelica polymorpha,Ipomoea batatas,Schisandra chinensis,Areca catechu,Glechoma longituba

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CCCCCCCCCCCCCC(=O)O

Synonyms

triacontyl alcohol/Nutron/3H-myristic acid/myricyl/1-tetradecanoic acid/n-TETRADECANOIC ACID/tetradecoic acid/Tetradecanoic acid/WELL-BLOOM/n-Myristic acid/myricyl alcohol/MIRACULAN/myristolic acid/Prosopol/Myristic acid/melissyl/melissyl alcohol/1-triaconatanol/Tomatex/1-hydroxytriacontane

IUPAC Name

tetradecanoic acid

Density

0.9±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

144.8±12.5 °C

Boiling Point

319.6±5.0 °C at 760 mmHg

Melting Point

52-54 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2915900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:544-63-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

30980919

Abstract

Decreased levels of the δ isozyme of diacylglycerol kinase (DGK) in skeletal muscle attenuate glucose uptake and, consequently, are critical for the pathogenesis of type 2 diabetes. We recently found that free myristic acid (14:0), but not free palmitic acid (16:0), increased the DGKδ protein levels and enhanced glucose uptake in C2C12 myotube cells. However, it has been unclear how myristic acid regulates the level of DGKδ2 protein. In the present study, we characterized the myristic acid-dependent increase of DGKδ protein. A cycloheximide chase assay demonstrated that myristic acid, but not palmitic acid, markedly stabilized DGKδ protein. Moreover, other DGK isozymes, DGKη and ζ, as well as glucose uptake-related proteins, such as protein kinase C (PKC) α, PKCζ, Akt and glycogen synthase kinase 3β, failed to be stabilized by myristic acid. Furthermore, DGKδ was not stabilized in cultured hepatocellular carcinoma cells, pancreas carcinoma cells or neuroblastoma cells, and only a moderate stabilizing effect was observed in embryonic kidney cells. A proteasome inhibitor and a lysosome inhibitor, MG132 and chloroquine, respectively, partly inhibited DGKδ degradation, suggesting that myristic acid prevents, at least in part, the degradation of DGKδ by the ubiquitin-proteasome system and the autophagy-lysosome pathway. Overall, these results strongly suggest that myristic acid attenuates DGKδ protein degradation in skeletal muscle cells and that this attenuation is fatty acid-, protein- and cell line-specific. These new findings provide novel insights into the molecular mechanisms of the pathogenesis of type 2 diabetes mellitus.

Copyright © 2019 Elsevier B.V. All rights reserved.

KEYWORDS

Diacylglycerol kinase; Myotube; Myristic acid; Protein degradation; Protein stabilization; Type 2 diabetes

Title

Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells.

Author

Iwata K1, Sakai H2, Takahashi D3, Sakane F4.

Publish date

2019 Jul

PMID

31586509

Abstract

Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.

KEYWORDS

Biomarkers; Kinetics; Myristic acid; Sepsis

Title

Kinetics of Myristic Acid Following Accidentally Induced Septic Response.

Author

Zazula R1, Průcha M2, Pehal F2, Dryahina K3, Moravec M4,5, Muller M4, Nejtek T4,5.

Publish date

2019

PMID

28886572

Abstract

BACKGROUND:
A mixture of eight fatty acids (lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, elaidic acid, and linoleic acid) that are contained in human amniotic fluid, colostrum, and milk produces appetitive responses in newborns, suggesting the existence of a transition of sensorial cues that guide newborns to the maternal breast.

OBJECTIVE:
To explore the ability of each of these eight fatty acids individually to produce appetitive responses in newborns.

METHODS:
The study included 12 healthy human newborns<24h after birth. Using a longitudinal design, cotton swabs that were impregnated with each of the eight fatty acids and control substances (i.e., vehicle, saline, and vanilla) were placed approximately 1cm from the newborns’ nostrils for 30s. Positive responses that were suggestive of acceptance included appetitive movements (i.e., suckling) and sniffing that were directed toward the cotton swab. Lateral movements of the head away from the swab were considered negative responses. Remaining stationary with no changes in facial expressions was considered indifference.

RESULTS:
Compared with controls (i.e., vehicle, saline, and vanilla) and the other fatty acids tested, myristic acid produced the longest duration of positive facial responses (suckling and sniffing). No significant differences in negative facial responses were observed in response to the odoriferous stimuli. No reactions that were suggestive of disgust were observed.

CONCLUSION:
A complex combination of stimuli, including the odor of myristic acid, may integrate sensory cues that guide newborns to the maternal breast.

Copyright © 2017 Elsevier B.V. All rights reserved.

KEYWORDS

Appetitive behavior; Fatty acids; Myristic acid; Newborn recognition; Olfactory stimulation; Prenatal learning

Title

Myristic acid in amniotic fluid produces appetitive responses in human newborns.

Author

Gutierrez-Garcia AG1, Contreras CM2, Diaz-Marte C3.

Publish date

2017 Dec


Description :

Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils