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N-[2-Isopropylthiazol-4-ylmethyl(methyl)carbamoyl]-L-valine

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1197

  • Specification : 98%(HPLC)

  • CAS number : 154212-61-0

  • Formula : C14H23N3O3S

  • Molecular Weight : 313.42

  • PUBCHEM ID : 9818282

  • Volume : 5mg

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Catalogue Number

BN-O1197

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

313.42

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)O

Synonyms

L-Valine, N-[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]-/Ureidovaline/N-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valine/N-{[(2-Isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}-L-valine/N-[2-Isopropylthiazol-4-ylMethyl(Methyl)carbaMoyl]-L-valine/N-((N-METHYL-N-((2-ISOPROPYL-4-THIAZOLYL)METHYL)AMINO)CARBONYL)-L-VALINE

IUPAC Name

(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoic acid

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

275.9±27.3 °C

Boiling Point

532.6±40.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

OSQWRZICKAOBFA-NSHDSACASA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:154212-61-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

14896119

Title

Vital Statistics

Publish date

1952 Feb 2;

PMID

27099644

Abstract

Background
Minimal residual disease (MRD) testing by higher performance techniques such as flow cytometry and polymerase chain reaction (PCR) can be used to detect the proportion of remaining leukemic cells in bone marrow or peripheral blood during and after the first phases of chemotherapy in children with acute lymphoblastic leukemia (ALL). The results of MRD testing are used to reclassify these patients and guide changes in treatment according to their future risk of relapse.

We conducted a systematic review of the economic literature, cost-effectiveness analysis, and budget-impact analysis to ascertain the cost-effectiveness and economic impact of MRD testing by flow cytometry for management of childhood precursor B-cell ALL in Ontario.

Methods
A systematic literature search (1998-2014) identified studies that examined the incremental cost-effectiveness of MRD testing by either flow cytometry or PCR. We developed a lifetime state-transition (Markov) microsimulation model to quantify the cost-effectiveness of MRD testing followed by risk-directed therapy to no MRD testing and to estimate its marginal effect on health outcomes and on costs. Model input parameters were based on the literature, expert opinion, and data from the Pediatric Oncology Group of Ontario Networked Information System. Using predictions from our Markov model, we estimated the 1-year cost burden of MRD testing versus no testing and forecasted its economic impact over 3 and 5 years.

Results
In a base-case cost-effectiveness analysis, compared with no testing, MRD testing by flow cytometry at the end of induction and consolidation was associated with an increased discounted survival of 0.0958 quality-adjusted life-years (QALYs) and increased discounted costs of $4,180, yielding an incremental cost-effectiveness ratio (ICER) of $43,613/QALY gained. After accounting for parameter uncertainty, incremental cost-effectiveness of MRD testing was associated with an ICER of $50,249/QALY gained. In the budget-impact analysis, the 1-year cost expenditure for MRD testing by flow cytometry in newly diagnosed patients with precursor B-cell ALL was estimated at $340,760. We forecasted that the province would have to pay approximately $1.3 million over 3 years and $2.4 million over 5 years for MRD testing by flow cytometry in this population.

Conclusions
Compared with no testing, MRD testing by flow cytometry in newly diagnosed patients with precursor B-cell ALL represents good value for money at commonly used willingness-to-pay thresholds of $50,000/QALY and $100,000/QALY.

Title

Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: An Economic Analysis

Author

Health Quality Ontario

Publish date

2016

PMID

19223294

Abstract

Structural chromosome aberrations are hallmarks of many human genetic diseases. The precise mapping of translocation breakpoints in tumors is important for identification of genes with altered levels of expression, prediction of tumor progression, therapy response, or length of disease-free survival, as well as the preparation of probes for detection of tumor cells in peripheral blood. Similarly, in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for carriers of balanced, reciprocal translocations benefit from accurate breakpoint maps in the preparation of patient-specific DNA probes followed by a selection of normal or balanced oocytes or embryos. We expedited the process of breakpoint mapping and preparation of case-specific probes by utilizing physically mapped bacterial artificial chromosome clones. Historically, breakpoint mapping is based on the definition of the smallest interval between proximal and distal probes. Thus, many of the DNA probes prepared for multiclone and multicolor mapping experiments do not generate additional information. Our pooling protocol, described here with examples from thyroid cancer research and PGD, accelerates the delineation of translocation breakpoints without sacrificing resolution. The turnaround time from clone selection to mapping results using tumor or IVF patient samples can be as short as 3 to 4 days. (J Histochem Cytochem 57:587-597, 2009)

KEYWORDS

translocation, chromosome aberration, cytogenetics, thyroid cancer, IVF, PGD, fluorescence in situ hybridization, bacterial artificial chromosome, DNA probes

Title

DNA Probe Pooling for Rapid Delineation of Chromosomal Breakpoints

Author

Chun-Mei Lu, Johnson Kwan, Adolf Baumgartner, Jingly F. Weier, Mei Wang, Tomas Escudero, Santiago Munne, Horst F. Zitzelsberger, and Heinz-Ulrich G. Weier

Publish date

2009 Jun;


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