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Narcissin

$113

  • Brand : BIOFRON

  • Catalogue Number : BF-N2013

  • Specification : 98%

  • CAS number : 604-80-8

  • Formula : C28H32O16

  • Molecular Weight : 624.54

  • PUBCHEM ID : 5481663

  • Volume : 20mg

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Catalogue Number

BF-N2013

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

624.54

Appearance

Yellow crystalline powder

Botanical Source

Punica granatum,Dendrobium nobile,Ginkgo biloba,Hippophae rhamnoides subsp.sinensis,Bupleurum longicaule var. giraldii

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)OC)O)O)O)O)O)O

Synonyms

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-/5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranoside/Isorhamnetin 3-O-rutinoside/5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H/chromen-4-one/Narcissoside/5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on/5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-3-yl-6-O-(6-deoxy-α-D-mannopyranosyl)-β-D-glucopyranoside/6-O-(6-Desoxy-α-D-mannopyranosyl)-β-D-glucopyranoside de 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-3-yle/Narcissin/Isorhamnetin 3-rhamnoglucoside/Narcisin/Isorhamnetin-3-O-Beta-D-rutinoside/5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one/Isorhamnetin 3-rutinoside

IUPAC Name

5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Density

1.7±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

312.9±27.8 °C

Boiling Point

953.1±65.0 °C at 760 mmHg

Melting Point

182-184ºC

InChl

InChI=1S/C28H32O16/c1-9-18(32)21(35)23(37)27(41-9)40-8-16-19(33)22(36)24(38)28(43-16)44-26-20(34)17-13(31)6-11(29)7-15(17)42-25(26)10-3-4-12(30)14(5-10)39-2/h3-7,9,16,18-19,21-24,27-33,35-38H,8H2,1-2H3/t9-,16+,18-,19+,21+,22-,23+,24+,27+,28-/m0/s1

InChl Key

UIDGLYUNOUKLBM-GEBJFKNCSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:604-80-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

2958996

Title

[Comparison of effects of narcissin and ligustrazin on cardiac hemodynamics].

Author

Chen LF, Wang GX, Li QA, Liu GH.

Publish date

1987 Mar

PMID

4437312

Title

Isolation of isorhamnetin-3-rutinoside (Narcissin) and quercetin-3-glucoside from the leaves and stems of Leontice leontopetalum.

Author

Cubukcu B, Yazgan A.

Publish date

1974 Sep


Description :

Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. PUMID/DOI:25709205 Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23. BACKGROUND:||Bupleurum L. (Aspiaceae) species are used as herbal remedy in Chinese traditional medicine.||OBJECTIVE:||The aim was to investigate the flavonoids in three annual European Bupleurum species, including B. baldense, B. affine and B. flavum, and to test their antioxidant and possible hepatoprotective effects.||MATERIALS AND METHODS:||Flavonoids from the methanol-aqueous extracts were quantified by solid-phase extraction-high-performance liquid chromatography. Bupleurum extracts (1-220 mg/ml) were tested for their antioxidant activity in DPPH and ABTS assays, as well as on isolated liver rat microsomes. In vitro hepatoprotective activity of B. flavum flavonoid (BFF) mixture and rutin, and Narcissoside, isolated from the same mixture, were evaluated on carbon tetrachloride (CCl4) and tert-butyl hydroperoxide (t-BuOOH) toxicity models in isolated rat hepatocytes.||RESULTS:||Narcissoside was the dominant flavonol glycoside in B. flavum being present at 24.21 ± 0.19 mg/g, whilst the highest content of rutin (28.63 ± 1.57 mg/g) was found in B. baldense. B. flavum possessed the strongest DPPH (IC50 22.12 μg/ml) and ABTS (IC50 118.15 μg/ml) activity. At a concentration 1 mg/ml of BFF (rutin 197.58 mg/g, narcissin 75.74 mg/g), a stronger antioxidant effect in microsomes was evidenced in comparison with silymarin, rutin and Narcissoside. The hepatoprotective effect of BFF significantly reduced the elevated levels of lactate dehydrogenase and malondialdehyde, and ameliorated glutathione, being most active in t-BuOOH-induced injury model when compared with CCl4 toxicity (P < 0.001).||CONCLUSION:||In BFF, synergism of rutin and Narcissoside could be responsible for stronger protection against mitochondrial induced oxidative stress.