Yellow crystalline powder
4′,5,7-Trihydroxyflavanone/4’,5,7-Trihydroxyflavanone/Naringenin/4',5,7-trihydroxyflavanone/(S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one/(±)-Naringenin/Salipurol/naringenine/4' 5 7-trihydroxyflavanone/4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)-/Derivative of/(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one/4‘,5,7-Trihydroxyflavanone/(2S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one/pelargidanon 1602/5,7,4'-trihydroxyflavanone/4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2S)-/rac-naringenin/Salipurpol/Naringetol
Methanol; Acetontrile; DMSO
577.5±50.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:480-41-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Flavonoids are valuable natural products widely used in human health and nutrition applications. Engineering microbial consortia to express complex flavonoid biosynthetic pathways is a promising approach for flavonoid production. In this study, the entire flavonoid biosynthetic pathway was split into two independent pathways, each of which was contained in separate Saccharomyces cerevisiae cells. The first cell type, sNAR5, which was genetically engineered to express the naringenin biosynthetic pathway, produced 144.1 mg/L naringenin. The second cell type was genetically modified with the heterologous naringenin-to-delphinidin pathway. A coculture produced a delphinidin titer, significantly higher than that produced in a monoculture of strain sDPD2, harboring the entire pathway. Furthermore, we successfully employed this coculture platform for the production of 3 flavonols and 2 anthocyanidins in flask-scale culture. This coculture platform paves the way for the development of an economical and efficient process for microbial flavonoid production.
Saccharomyces cerevisiae; flavonoid; metabolic engineering; microbial coculture; naringenin
Engineering Saccharomyces cerevisiae Coculture Platform for the Production of Flavonoids.
Du Y1, Yang B1, Yi Z1, Hu L1, Li M1.
2020 Feb 19
Peripheral nerve injuries are common conditions that often lead to dysfunctions. Although much knowledge exists on the several factors that mediate the complex biological process involved in peripheral nerve regeneration, there is a lack of effective treatments that ensure full functional recovery. Naringenin (NA) is the most abundant flavanone found in citrus fruits and it has promising neuroprotective, anti-inflammatory and antioxidant effects. This study aimed to enhance peripheral nerve regeneration using an inclusion complex containing NA and hydroxypropyl-β-cyclodextrin (HPβCD), named NA/HPβCD. A mouse sciatic nerve crush model was used to evaluate the effects of NA/HPβCD on nerve regeneration. Sensory and motor parameters, hyperalgesic behavior and the sciatic functional index (SFI), respectively, improved with NA treatment. Western blot analysis revealed that the levels of p75NTR ICD and p75NTR full length as well phospho-JNK/total JNK ratios were preserved by NA treatment. In addition, NA treatment was able to decrease levels of caspase 3. The concentrations of TNF-α and IL-1β were decreased in the lumbar spine, on the other hand there was an increase in IL-10. NA/HPβCD presented a better overall morphological profile but it was not able to increase the number of myelinated fibers. Thus, NA was able to enhance nerve regeneration, and NA/HPβCD decreased effective drug doses while maintaining the effect of the pure drug, demonstrating the advantage of using the complex over the pure compound.
Copyright © 2019 Elsevier Inc. All rights reserved.
Cyclodextrin; Flavonoids; IL-10; Naringenin; Peripheral nerve injury; Regeneration; TNF-α; p75(NTR)
Naringenin complexed with hydroxypropyl-β-cyclodextrin improves the sciatic nerve regeneration through inhibition of p75NTR and JNK pathway.
Oliveira MA1, Heimfarth L1, Passos FRS1, Miguel-Dos-Santos R1, Mingori MR2, Moreira JCF2, Lauton SS3, Barreto RSS1, Araújo AAS4, Oliveira AP5, Oliveira JT6, Baptista AF7, Martinez AMB6, Quintans-Júnior LJ8, Quintans JSS9.
2020 Jan 15
The study investigated the efficacy of two GRAS-status phytochemicals, mega-resveratrol (RV) and naringenin (NG) to inactivate Escherichia coli O157:H7 (EHEC) in apple cider. A five-strain mixture of EHEC (∼7 log CFU/ml) was inoculated into cider, followed by the addition of RV (8.7 mM and 13.0 mM) or NG (7.3 mM and 11.0 mM). The cider samples were stored at 4 °C for 14 days and EHEC was enumerated on days 0,1,5,7 and 14. The deleterious effects of RV and NG on EHEC cells were visualized by scanning electron microscopy (SEM), and RT-qPCR was done to determine the effect of phytochemicals on three known acid resistance (AR) systems of EHEC. NG was more effective than RV and reduced EHEC counts by ∼4.5 log CFU/ml by day 14, whereas RV reduced counts by ∼2.5 log CFU/ml compared to controls (P < 0.05). SEM showed that RV and NG resulted in the destruction of EHEC cells, and surviving bacteria appeared ‘lemon shaped’. RT-qPCR results revealed that RV and NG downregulated the transcription of AR associated genes in EHEC (P < 0.05). Results suggest the potential use of RV and NG as natural antimicrobial additives to enhance the microbiological safety of apple cider. However, sensory analysis studies are warranted.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Cider; EHEC; Naringenin; Resveratrol
Inactivation of Escherichia coli O157:H7 in apple cider by resveratrol and naringenin.
Surendran Nair M1, Ma F2, Lau P3, Upadhyaya I4, Venkitanarayanan K5.
Naringenin is the predominant flavanone in grapefruit; displays strong anti-inflammatory and antioxidant activities.