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Nervonic acid

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-N2004

  • Specification : 98%

  • CAS number : 506-37-6

  • Formula : C24H46O2

  • Molecular Weight : 366.62

  • PUBCHEM ID : 5281120

  • Volume : 20mg

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Catalogue Number

BF-N2004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

366.62

Appearance

White Cryst.

Botanical Source

synthesis

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CCCCCCCCC=CCCCCCCCCCCCCCC(=O)O

Synonyms

nervonoyl acid/SELACHOLEIC ACID/cis-tetracosenoic acid/CIS-15-TETRACOSENICACID/cis-15-Tetracosenic acid/(15Z)-Tetracos-15-enoic acid/(Z)-tetracos-15-enoic acid/cis-15-Tetracosenoic Acid/15Z-tetracosenoic acid/selacholeic/C24:1 (CIS-15) ACID/tetracosenic acid/15-TETRACOSENOIC ACID/Physetolic acid/cis-selacholeic acid/Nervonic acid/(Z)-15-Tetracosenoic acid/(15Z)-Tetracosenoic acid/cis-15-Teracosenoic acid/NERVONIC ACID(RG)/(15Z)-15-Tetracosenoic acid/15-Tetracosenoic acid, (15Z)-/NERVONIC ACID (CIS)/cis-15-Tetracosenoic acid,Selacholeic acid

IUPAC Name

(Z)-tetracos-15-enoic acid

Density

0.9±0.1 g/cm3

Solubility

Flash Point

375.8±15.2 °C

Boiling Point

479.2±14.0 °C at 760 mmHg

Melting Point

42-43 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2916190000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:506-37-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31421462

Abstract

This study assesses and compares the influence of silver nanoparticles (AgNPs) and silver nitrate (AgNO3) on the fatty acid composition, pigments, and growth indices of Chlorella vulgaris. Toxicity testing was carried at the estimated and/or above predicted environmental concentrations of AgNPs and AgNO3. AgNO3 treatments impaired the population growth of C. vulgaris about 2-183 times more than the respective AgNPs ones. The pigments displayed a concentration-dependent decrease in response to both forms of silver; however, AgNO3 displayed higher severity to the pigments than AgNPs. In exposure to 10 μg L-1 AgNO3, the contents of chlorophyll a, chlorophyll b, total chlorophyll, and carotenoid, respectively, demonstrated a reduction of about 5, 3, 4, and 4 times when compared with the same respective concentration of AgNPs. Total amounts of saturated (∑SFA), monounsaturated (∑MUFA), and polyunsaturated (∑PUFA) fatty acids as well as the ratio of unsaturated to saturated ones (Unsat./Sat.) displayed somewhat similar-concentration responses. ∑SFA exhibited a hormesis response, and ∑MUFA, ∑PUFA, and Unsat./Sat. did a decreasing trend with increasing concentration of AgNPs and AgNO3. Myristoleic acid, nervonic acid, and eicosadienoic acid revealed the highest sensitivity. Pearson analysis illustrated the highest correlation among myristoleic acid, eicosenoic acid, and nervonic acid as well as among palmitic acid, stearic acid, palmitoleic acid, and oleic acid. Taken together, AgNPs and the released ions could disrupt physiological health state of microalgae through perturbation in the fatty acid composition (especially MUFAs and PUFAs) and other macromolecules. These types of bioperturbations could change the good health state of aquatic ecosystems.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Aquatic nanotoxicology; Chlorophyll; Fatty acids; Lipidomics; Metal nanoparticles; Microalgae

Title

Perturbation of fatty acid composition, pigments, and growth indices of Chlorella vulgaris in response to silver ions and nanoparticles: A new holistic understanding of hidden ecotoxicological aspect of pollutants.

Author

Behzadi Tayemeh M1, Esmailbeigi M2, Shirdel I3, Joo HS4, Johari SA5, Banan A6, Nourani H7, Mashhadi H8, Jami MJ9, Tabarrok M10.

Publish date

2020 Jan

PMID

31416149

Abstract

Nervonic acid (24:1 n-9, NA) plays a crucial role in the development of white matter, and it occurs naturally in human milk. This study aims to quantify NA in human milk at different lactation stages and compare it with the NA measured in infant formulae. With this information, optimal nutritional interventions for infants, especially newborns, can be determined. In this study, an absolute detection method that uses experimentally derived standard curves and methyl tricosanoate as the internal standard was developed to quantitively analyze NA concentration. The method was applied to the analysis of 224 human milk samples, which were collected over a period of 3-30 days postpartum from eight healthy Chinese mothers. The results show that the NA concentration was highest in colostrum (0.76 ± 0.23 mg/g fat) and significantly decreased (p < 0.001) in mature milk (0.20 ± 0.03 mg/g fat). During the first 10 days of lactation, the change in NA concentration was the most pronounced, decreasing by about 65%. Next, the NA contents in 181 commercial infant formulae from the Chinese market were compared. The NA content in most formulae was <16% of that found in colostrum and less than that found in mature human milk (p < 0.05). No significant difference (p > 0.05) was observed among NA content in formulae with different fat sources. Special attention was given to the variety of n-9 fatty acids in human milk during lactation, and the results indicated that interindividual variation in NA content may be primarily due to endogenous factors, with less influence from the maternal diet.

KEYWORDS

human milk fat; infant formula; lactational stage; n-9 fatty acid; nervonic acid

Title

Quantification of Nervonic Acid in Human Milk in the First 30 Days of Lactation: Influence of Lactation Stages and Comparison with Infant Formulae.

Author

Yu J1,2, Yuan T1,2, Zhang X1,2, Jin Q1,2, Wei W3,4, Wang X5,6.

Publish date

2019 Aug 14;

PMID

31387306

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. The disturbances in the fatty acid composition of stored lipids are more important than the lipid species itself, which may influence the overall effect caused by these molecules. Thus, uncovering time-dependent changes in the fatty acid composition of accumulated lipid fractions after a high fat diet seems to be a new marker of NAFLD occurrence. The experiments were conducted on high fat fed Wistar rats. The blood and liver samples were collected at the end of each experimental week and used to assess the content of lipid fractions and their fatty acid composition by gas liquid chromatography. The expression of proteins from lipid metabolism pathways and of fatty acid exporting proteins were detected by Western blotting. In the same high fat feeding period, decreased de novo lipogenesis, increased β-oxidation and lipid efflux were demonstrated. The observed effects may be the first liver protective mechanisms against lipotoxicity. Nevertheless, such effects were still not sufficient to prevent the liver from proinflammatory lipid accumulation. Moreover, the changes in liver metabolic pathways caused the plasma nervonic acid concentration in sphingomyelin to decrease simultaneously with NAFLD development, which may be a steatosis occurrence prognostic marker.

KEYWORDS

Diacylglycerol; desaturation; diet and dietary lipids; elongation; fatty acid metabolism; fatty acids; lipogenesis; liver; nervonic acid

Title

High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD.

Author

Konstantynowicz-Nowicka K1, Berk K2, Chabowski A2, Kasacka I3, Bielawiec P2, Łukaszuk B2, Harasim-Symbor E2.

Publish date

2019 Aug 5


Description :

Nervonic acid is a monounsaturated fatty acid important in the biosynthesis of myelin.