Nirazin/Nicarbazine/Nicrazin/Nicarbazin/Nicarb/Nicrazine/Nicoxin/Nicarbasin/N,N'-bis(4-Nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone/MK 75
1.4663 (rough estimate)
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
414.8ºC at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:330-95-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Four floor pen studies were carried out to evaluate the effects of nicarbazin (NIC) administration on blood glucose concentrations and the onset of hypoglycemia in broiler chickens. All tests involved continuous NIC feeding at 0, 100, or 125 ppm to 28 days of age. In each study, birds were reared at both standard environmental temperatures and at 3 C below this level. In addition, two studies were conducted in the presence of coccidial infection and two were carried out in noninfected broilers. At 26 days of age in each test, two birds per pen were bled by puncture of the brachial vein, and whole blood glucose concentrations were determined. Results indicated that the administration of NIC to broilers for 26 days had no effect on blood glucose concentrations, although graded levels of NIC tended to increase these values. In addition, no evidence of hypoglycemia was recorded in any of the trials. In a similar fashion, blood glucose was unaffected by environmental temperature and coccidial challenge. These findings support previous work showing that NIC administration does not influence blood glucose levels and indicate that the product is not involved when field diagnoses use reduced blood glucose and hypoglycemia as indicators of production anomalies.
Eimeria; blood glucose; coccidiosis; hypoglycemia; nicarbazin.
Blood Glucose Concentrations in Nicarbazin-Fed Broiler Chickens
K W Bafundo 1, M J da Costa 2, G M Pesti 2
Nicarbazin is one of the major anticoccidials used in broiler feeds. The compound 4,4′-dinitrocarbanilide (DNC) is the marker residue of concern left from nicarbazin in chicken meat. The effect of thermal processing on DNC content accumulated in chicken breast was assessed, and samples were analyzed by liquid chromatography-tandem mass spectrometry. Five conventional cooking methods were evaluated: boiling, grilling, microwaving, frying, and roasting. To ensure DNC in meat, broilers were fed nicarbazin without withdrawal period. All heating methods surpassed the 70 °C end point core temperature in chicken breast. Maximum DNC degradation was reached at 10 min for boiling, at 30 min for grilling, and at 2 min for microwaving, and no further reduction was observed for longer thermal processing time. Boiling was more efficient in reducing DNC (69%). Grilling, microwaving, and frying achieved on average 55% of degradation. The outcomes reported herein may be considered in decision-making regarding further review of maximum residue limits.
DNC degradation; LC-MS/MS; chicken fillet; cooking method; heating treatment; nicarbazin.
Degradation of 4,4'-Dinitrocarbanilide in Chicken Breast by Thermal Processing
Danniele Miranda Bacila 1, Anildo Cunha Jr 2, Indianara Fabiola Weber 3, Gerson Neudi Scheuermann 2, Arlei Coldebella 2, Luizinho Caron 2, Luciano Molognoni 4, Heitor Daguer 4, Luciana Igarashi Mafra 1, Vivian Feddern 2
2018 Aug 8
Veterinary pharmaceuticals are widely used as food additives in the poultry industry, and the unknown consequences of releasing these compounds into the environment are of concern. The purpose of the present study was to determine the direct impact of 2 veterinary pharmaceuticals (nicarbazin and monensin), commonly used in the poultry industry, on nontarget invertebrates and plant species. Ecotoxicological tests were used to evaluate the acute and chronic toxicity in earthworms (Eisenia andrei), collembolans (Folsomia candida), and 2 plant species (Brassica rapa and Triticum aestivum). Chemical analytical measurements were in good agreement with the nominal concentrations used, although some variability was seen. The results obtained showed no effects of nicarbazin at the highest nominal tested concentration of 1000 mg a.i./kg soil dry weight on any of the organisms, whereas exposure to monensin caused a concentration-specific response pattern. Species sensitivity to monensin decreased in the following rank order: B. rapa > T. aestivum > E. andrei > F. candida, with measured median effect concentrations (based on soil exposure) ranging between approximately 10 and 120 mg/kg. Our results emphasize the importance of using a test battery when assessing ecotoxicological effects by using different ecophysiological endpoints and species from different trophic levels. Environ Toxicol Chem 2018;37:3145-3153. © 2018 SETAC.
Ecotoxicology; Monensin; Nicarbazin; Plants; Soil contamination; Soil invertebrates.
Hazard Assessment of the Veterinary Pharmaceuticals Monensin and Nicarbazin Using a Soil Test Battery
V Menezes-Oliveira 1, S Loureiro 1, M J B Amorim 1, F Wrona 2 3, A M V M Soares 1