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Nicotinamide

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-N2007

  • Specification : 98%

  • CAS number : 98-92-0

  • Formula : C6H6N2O

  • Molecular Weight : 122.12

  • PUBCHEM ID : 936

  • Volume : 20mg

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Catalogue Number

BF-N2007

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

122.12

Appearance

White crystal

Botanical Source

herbs of Nicotiana tabacum L.

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=CN=C1)C(=O)N

Synonyms

Niacinamide/Nicotinic acid amide/Vitamin- B3/Witamina PP/3-Pyridinecarboxamide/Nicotinamide/Pyridine-3-carboxamide/T6NJ CVZ/Dipigyl/Vi-noctyl

IUPAC Name

pyridine-3-carboxamide

Density

1.2±0.1 g/cm3

Solubility

Methanol; DMSO

Flash Point

109.7±25.1 °C

Boiling Point

257.7±32.0 °C at 760 mmHg

Melting Point

128-131 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933390000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:98-92-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31994513

Abstract

AIM:
To assess an effect of the combined use of Cytoflavin and Sulodexide on the course and outcomes of purulent meningitis in children.

MATERIAL AND METHODS:
Fifty children with purulent meningitis, aged from 5 to 17 years 11 month, were studied. Thirty patients of the treatment group (n=30; mean age 6,8 ± 2,2 years) received Cytoflavin (0,6 mcg/kg once a day) during 5 days with the following treatment with Sulodexide (250 LSU/day in children 5-12 years, 500 LSU/day in children above 12 years). Patients of the comparison group (n=20), aged 5,9±1,8 years, received standard antibacterial treatment. Duration and persistent of fever, cerebral, meningeal symptoms, the recovery period of CSF, the normalization of the number of desquamated epithelial cells (DEC), D-dimer were estimated. Outcomes of purulent meningitis were assessed using a working scale representing a modification of Rankin’s, Fisher’s, and Glasgow scales.

RESULTS AND CONCLUSION:
The combination of drugs reduces the duration of cerebral and meningeal symptoms, leads to the normalization of hematological parameters (the level of leukocytes, desquamous epithelial cells, D-dimer) and improves outcomes.

KEYWORDS

Cytoflavin; Sulodexide; children; purulent meningitis; treatment

Title

[Possibilities for optimizing the pathogenetic therapy of purulent meningitis in children].

Author

Vilnits AA1, Skripchenko NV1, Gorelik EY2, Egorova ES2, Markova KV2.

Publish date

2019;

PMID

31940448

Abstract

Hormetic effects of fungicides on phytopathogens are of great importance for proper application of fungicides. The aim of the present study was to investigate the stimulatory effects of the fungicide boscalid on mycelial growth and virulence of the devastating plant pathogen Sclerotinia sclerotiorum. Boscalid in potato dextrose agar (PDA) at a dosage range from 0.0005 to 0.002 μg/ml exerted statistically significant (P ≤ 0.015) stimulations on mycelial growth of S. sclerotiorum, and the maximum stimulation magnitudes were 5.55 ± 0.73% (mean ± SD) for the four isolates tested. Boscalid in PDA at 0.02 μg/ml inhibited mycelial growth of isolates HLJ3H and HLJ4H by 15.0 and 8.9%, respectively. However, after the growth-inhibited mycelia were inoculated on rapeseed leaves, isolates HLJ3H and HLJ4H exhibited virulence stimulations of 8.7 and 17.8%, respectively, indicating that hormesis may be masked by inhibitions. Boscalid sprayed at 0.0001 to 0.1 μg/ml on detached rapeseed leaves had significant (P ≤ 0.041) stimulations on virulence of S. sclerotiorum, and the maximum stimulation magnitudes were 17.90 ± 5.94% (mean ± SD) for the four isolates tested. Experiments on 12 isolates with different levels of virulence showed there was a negative correlation (R = -0.663, P = 0.019) between the maximum virulence stimulation magnitude and virulence of S. sclerotiorum in the absence of fungicide. Boscalid at stimulatory concentrations had no significant effect on the expression levels of three virulence-associated genes that encode cutinase (SsCut), polygalacturonase (SsPG1), and oxaloacetate acetylhydrolase (SsOah1). The molecular mechanisms for hormetic effects of boscalid on S. sclerotiorum remain to be studied in the future.

KEYWORDS

chemical; disease management; field crops; fungi; oilseeds and legumes

Title

Stimulatory Effects of Boscalid on Virulence of Sclerotinia sclerotiorum Indicate Hormesis May Be Masked by Inhibitions.

Author

Hu S1, Xu Q1, Zhang Y1, Zhu F1.

Publish date

2020 Mar;

PMID

31863745

Abstract

Giardia duodenalis is a flagellated unicellular eukaryotic microorganism that commonly causes diarrheal disease throughout the world. Treatment of giardiasis is limited to nitroheterocyclic compounds as metronidazole and benzimidazoles as albendazole, where remarkably treatment failure is relatively common. Consequently, the need for new options to treat this disease is underscored. We predicted by a bioinformatic approach that nicotinamide inhibits Giardia sirtuins by the nicotinamide exchange pathway, and since sirtuins are involved in cell cycle control, they could be related with arrest and decrease of viability. When trophozoites were treated with nicotinamide (NAM), a strong arrest of Giardia trophozoites in G2 phase was observed and at the same time changes in transcriptional expression of sirtuins were produced. Interestingly, the G2 arrest is not related to double-strand breaks, which strengthens the role of sirtuins in the control of the Giardia cell cycle. Results with NAM-treated trophozoites as predicted demonstrate antigiardial effects and thus open new options for the treatment of giardiasis, either with the combination of nicotinamide with another antigiardial drug, or with the design of specific inhibitors for Giardia sirtuins.

Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS

DNA double-strand breaks; GdSir2.1-2.5; Giardiasis; Metronidazole; NAM

Title

Nicotinamide induces G2 cell cycle arrest in Giardia duodenalis trophozoites and promotes changes in sirtuins transcriptional expression.

Author

Lagunas-Rangel FA1, Bazan-Tejeda ML1, Garcia-Villa E1, Bermúdez-Cruz RM2.

Publish date

2020 Feb;


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