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Nicotinic acid

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-N3009

  • Specification : 98%

  • CAS number : 59-67-6

  • Formula : C6H5NO2

  • Molecular Weight : 123.11

  • PUBCHEM ID : 938

  • Volume : 100mg

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Catalogue Number

BF-N3009

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

123.11

Appearance

White crystalline powder

Botanical Source

Glycine max

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=CN=C1)C(=O)O

Synonyms

3-Pyridinecarboxylic acid/Vitamin B3/5-22-02-00057/5-22-02-00057 (Beilstein Handbook Reference)/3-Pyridylcarboxylic acid/P. P. Factor/Pyridine-3-carboxylic acid/Pyridine-β-carboxylic acid/P.P. factor-pellagra preventive factor/T6NJ CVQ/Nicotinamide/antipellagra vitamin/nicotinic acid/Niacin

IUPAC Name

pyridine-3-carboxylic acid

Density

1.3±0.1 g/cm3

Solubility

Methanol; Water; DMSO

Flash Point

130.7±19.8 °C

Boiling Point

292.5±13.0 °C at 760 mmHg

Melting Point

128-131 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2936290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:59-67-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32244770

Abstract

Recently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise promotes the adaptation of muscle to regular exercise and improves the endurance performance to a greater extent than exercise alone. Thus, 30 adult mice were randomly divided into three groups of 10 mice/group. The control and the exercise (EX) group received an adequate NA diet, while the EX + NA group received a high NA diet. Mice of the EX and the EX + NA group were subjected to a treadmill endurance exercise program five times/week during the experimental period of 42 days. At day 41, endurance performance was greater in the EX + NA group than in the control and the EX group (P < 0.05). Mice of the EX + NA group had a higher type IIA (+60%) and a lower type IIB (-55%) fiber percentage in gastrocnemius (GN) muscle than control mice (P < 0.05), while the type I fiber percentage in GN muscle tended to be increased (+100%) in the EX + NA group compared to the control group (P = 0.051). In the EX + NA group, glycogen concentration (+15%) and mRNA levels of two glycolytic (+70-80%) and two glycogenolytic enzymes (+80-120%) in GN muscle were increased compared to the control group (P < 0.05). In conclusion, feeding a high NA diet induces changes in skeletal muscle fiber composition and improves endurance performance of mice subjected to regular endurance exercise.

KEYWORDS

adaptation; endurance; exercise; nicotinic acid; skeletal muscle; unfolded protein response

Title

Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise.

Author

Ringseis R1, Gessner DK1, Beer AM1, Albrecht Y1, Wen G1, Most E1, Kruger K2, Eder K1.

Publish date

2020 Apr 1

PMID

13623579

Title

Nicotinic acid.

Author

ISSELBACHER KJ, DAWSON AM.

Publish date

1959 Jan

PMID

13239818

Title

[Nicotinic acid content of coffee].

Author

ADAMO G.

Publish date

1955 Jan-Feb


Description :

Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.Target: OthersNiacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition.Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.