This product is isolated and purified from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan.
2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)-2-propanyl β-D-glucopyranoside/2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)propan-2-yl β-D-glucopyranoside/2-[1-(b-D-Glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g]benzopyran-7-one/7H-Furo[3,2-g]benzopyran-7-one, 3-[1-(β-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-/Nodakenetin Glucoside
Inhibitory effects of nodakenin on the airway inflammation and NF-κB signaling pathway in a murine asthmatic model.[Reference: WebLink]Effect of nodakenin on atopic dermatitis-like skin lesions.[Pubmed: 25209505]Biosci Biotechnol Biochem. 2014;78(9):1568-71. Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic and anti- inflammatory activities. We have previously shown that Nodakenin inhibits IgE/Ag-induced degranulation in mast cells. METHODS AND RESULTS: In this study, we investigated the inhibitory effect of Nodakenin on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)- like skin lesions in ICR mice. Scratching behavior, skin severity score, blood IgE level, and skin thickness were improved in DNCB-induced AD-like ICR mice. Our results showed that Nodakenin suppressed the increase of AD-like skin lesions in ICR mice. CONCLUSIONS: These results suggest that Nodakenin may be a potential therapeutic resource for AD as well as an adjunctive agent to control itching associated with AD.Basic & Clinical Medicine, 2014 , 34 (5) :690-4. To observe the effects of Nodakenin on airway inflammation in a mouse model of allergic asthma. METHODS AND RESULTS: BALB / c mice were assigned randomly to one of the following four experimental groups: control, model,Nodakenin and dexamethasone. All test mice were sensitized and challenged by OVA to induce airway inflammation. One hour before OVA challenge,Nodakenin group was intragastrically administered with Nodakenin at a dose of 10 mg / kg,and dexamethasone group was intraperitoneally injected with dexamethasone a dose of 1 mg / kg. Airway responsiveness was measured by a lung function analysis systems. The number of total leukocytes in BALF was counted using a hemocytometer,and differential cells were counted using Diff-Quick-stained smears. Histopathology of lung tissue was analyzed by Hematoxylin-eosin staining. Levels of inflammatory mediators in serum or BALFs were measured by ELISA. The activity and expression of proteins in NF-κB signaling pathway was respectively evaluated by EMSA and western blot analysis. Compared with control group,the model groupexhibited obvious airway inflammation,airway reactivity was significantly increased,the level of total cells and differential cells was significantly increased,levels of IL-4,IL-5,IL-13,IgE were significantly increased,levels of nuclear P65 and p-P65 protein was significantly enhanced,level of cytoplasmic P65 and IκBα protein was significantly decreased,and the NF-κB DNA binding activity was significantly increased. Compared with model group, Nodakenin significantly suppressed airway inflammation,airway hyperreactivity,reduced levels of IL-4,IL-5 and IL-13 in BALF,and IgE in serum,decreased levels of nuclear P65 and p-P65 protein,increased cytoplasmic P65 and IκBα protein,and increased the NF-κB DNA binding activity. CONCLUSIONS:Nodakenin efficiently inhibits antigen-induced airway inflammation in asthmatic mouse.
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In our previous study, we demonstrated that nodakenin, a coumarin compound isolated from Angelica decursiva, ameliorates learning and memory impairments induced by scopolamine. In the present study, we investigated the effects of nodakenin on the cognitive function in the normal naïve mice in a passive avoidance task, and the results showed that nodakenin significantly increased the latency time in normal naïve mice. In addition, sub-chronic administration of nodakenin increased the number of 5-bromo-2-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus (DG) region. The percentage of BrdU and NeuN (neuronal cell marker)-immunopositive cells was also significantly increased by the nodakenin administration. Western blotting results showed that the expression levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β) were significantly increased in hippocampal tissue by sub-chronic nodakenin administration. These findings suggest that the sub-chronic administration of nodakenin enhances adult hippocampal neurogenesis in the DG region via Akt-GSK-3β signaling and this increase may be associated with nodakenin’s positive effect on cognitive processing.
Nodakenin Enhances Cognitive Function and Adult Hippocampal Neurogenesis in Mice.
Gao Q1, Jeon SJ, Jung HA, Lee HE, Park SJ, Lee Y, Lee Y, Ko SY, Kim B, Choi JS, Ryu JH.
Nodakenin, a coumarin isolated from the roots of Angelicae gigas, is effective for treating function control disorders, bacterial infections, pain, diarrhea, vitamin E deficiency, and for relaxation of the uterus. The aim of this study was to investigate the antiallergic related inflammatory effects in phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1) or anaphylactic activity in a mouse model. Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in PMACI-stimulated HMC-1. We also studied the inhibitory effects of nodakenin on the nuclear translocation of nuclear factor kappa B (NF-κB) and activation of caspase-1, inhibitory κB kinase (IKK), and Akt in PMACI-stimulated HMC-1. However, mitogen-activated protein kinase (MAPK) activation was not sufficient to abrogate the stimulus. In addition, administration of nodakenin at 20 mg/kg inhibited histamine release and protected mice against compound 48/80-induced anaphylactic mortality. Furthermore, Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation in compound 48/80-induced anaphylactic mice. These results suggest new insight that nodakenin may be a promising antiallergic related inflammatory agent for inflammatory disorders. J. Cell. Biochem. 118: 3993-4001, 2017.
© 2017 Wiley Periodicals, Inc.
ALLERGIC INFLAMMATION; CASPASE-1; MAST CELLS; NF-κB; NODAKENIN
The Inhibitory Effect of Nodakenin on Mast-Cell-Mediated Allergic Inflammation Via Downregulation of NF-κB and Caspase-1 Activation.
Lee NY1,2, Chung KS3, Jin JS2, Lee YC4, An HJ1.
Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic and anti- inflammatory activities. We have previously shown that nodakenin inhibits IgE/Ag-induced degranulation in mast cells. In this study, we investigated the inhibitory effect of nodakenin on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)- like skin lesions in ICR mice. Scratching behavior, skin severity score, blood IgE level, and skin thickness were improved in DNCB-induced AD-like ICR mice. Our results showed that nodakenin suppressed the increase of AD-like skin lesions in ICR mice. These results suggest that nodakenin may be a potential therapeutic resource for AD as well as an adjunctive agent to control itching associated with AD.
atopic dermatitis (AD); nodakenin; scratching behavior; skin severity
Effect of nodakenin on atopic dermatitis-like skin lesions.
Park SJ1, Cha HS, Lee YH, Kim WJ, Kim DH, Kim EC, Lee KH, Kim TJ.