fruits of Capsicum annuum L.
N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide/Nonanimidic acid, N-[(4-hydroxy-3-methoxyphenyl)methyl]-, (1Z)-/N-vanillyl-nonanamide/Vanillyl pelargonic amide/(N-(4-Hydroxy-3-methoxybenzyl)nonanamide/Nonivamide/Vanillyl-N-nonylamide/Pseudocapsaicin/Capsaicin (Synthetic)/N-VANILLYLNONANOAMIDE/Nonanamide, N-vanillyl-/Pelargonyl vanillylamide/N-Nonylvanylamide/NonvaMide/Capsaicin std./nonanoic acid vanillylamide/N-(4-Hydroxy-3-methoxybenzyl)nonanamide/Capsaicinoid/N-Pelargonic Acid Vanillylamide/Capsaicin synthetic/Pelargonic acid vanillylamide/NONYLVANYLAMIDE/N-Pelargonylvanillylamide/N-Vanillylnonanamide/Vanillyl n-nonoylamide/nonylic acid vanillylamide/PAVA/NON-4-ENE/(1Z)-N-(4-Hydroxy-3-methoxybenzyl)nonanimidic acid/Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-/N-Vanillylpelargonamide/N-Vanillyl nonan amide
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provides coniferyl ferulate(CAS#:2444-46-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
To monitor capsaicinoids in serum on-site, three new monoclonal antibodies (mAbs) were firstly proposed using a conjugate of 4-[(4-hydroxy-3-methoxybenzyl) amino]-4-oxobutanoic acid as the immunogen. Among them, the YQQD8 mAb showed the highest sensitivity and cross-reactivity to major capsaicinoids, such as capsaicin, dihydrocapsaicin and N-vanillylnonanamide. A competitive indirect enzyme-linked immunosorbent assay (icELISA) and a time-resolved fluorescent immunochromatographic assay (TRFICA) were established based on this mAb. The linear range was 1.1-27.0ngmL(-1) for icELISA and 1.9-62.5ngmL(-1) for TRFICA and the limit of detection (LOD) of TRFICA was 1.5ngmL(-1). To decrease the interference of sample components and increase accuracy, serum samples were diluted four times before assays. As a result, the linear range of serum samples was 4.6-107.9ngmL(-1) for icELISA and 7.6-250.0ngmL(-1) for TRFICA. Both icELISA and TRFICA showed good recoveries (91.0-112.8% for icELISA and 87.6-111.5% for TRFICA) and concordant results in spiked experiments. Overall, this is the first report of immunoassay based on the mAbs for quantitative determination of major capsaicinoids, and the results demonstrate that both methods can meet the demands of rapid on-site assay for capsaicinoids in serum samples.
Copyright © 2016 Elsevier B.V. All rights reserved.
Capsaicin; Capsaicinoids; Indirect competitive enzyme-linked immunosorbent assay (icELISA); Monoclonal antibody; Time-resolved fluorescent immunochromatographic assay (TRFICA)
Quantitative determination of major capsaicinoids in serum by ELISA and time-resolved fluorescent immunoassay based on monoclonal antibodies.
Yang Q1, Zhu J1, Ma F2, Li P3, Zhang L4, Zhang W5, Ding X6, Zhang Q7.
2016 Jul 15
Enteric viscerofugal neurons are interneurons with cell bodies in the gut wall; they project to prevertebral ganglia where they provide excitatory synaptic drive to sympathetic neurons which control intestinal motility and secretion. Here, we studied the mechanosensitivity and firing of single, identified viscerofugal neurons in guinea-pig distal colon. Flat sheet preparations of gut were set up in vitro and conventional extracellular recordings made from colonic nerve trunks. The nicotinic agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) (1mM), was locally pressure ejected onto individual myenteric ganglia. In a few ganglia, DMPP promptly evoked firing in colonic nerves. Biotinamide filling of colonic nerves revealed that DMPP-responsive sites corresponded to viscerofugal nerve cell bodies. This provides a robust means to positively identify viscerofugal neuron firing. Of 15 single units identified in this way, none responded to locally-applied capsaicin (1 μM). Probing with von Frey hairs at DMPP-responsive sites reliably evoked firing in all identified viscerofugal neurons (18/18 units tested; 0.8-5 mN). Circumferential stretch of the preparation increased firing in all 14/14 units (1-5 g, p<0.05). Both stretch and von Frey hair responses persisted in Ca(2+)-free solution (6 mM Mg(2+), 1mM EDTA), indicating that viscerofugal neurons are directly mechanosensitive. To investigate their adequate stimulus, circular muscle tension and length were independently modulated (BAY K8644, 1 μM and 10 μM, respectively). Increases in intramural tension without changes in length did not affect firing. However, contraction-evoked shortening, under constant load, significantly decreased firing (p<0.001). In conclusion, viscerofugal neuron action potentials contribute to recordings from colonic nerve trunks, in vitro. They provide a significant primary afferent output from the colon, encoding circumferential length, largely independent of muscle tension. All viscerofugal neurons are directly mechanosensitive, although they have been reported to receive synaptic inputs. In short, viscerofugal neurons combine interneuronal function with length-sensitive mechanosensitivity.
Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
Identification and mechanosensitivity of viscerofugal neurons.
Hibberd TJ1, Zagorodnyuk VP, Spencer NJ, Brookes SJ.
2012 Dec 6
The potential on N-vanillylnonanamide (NVN) in preventing the attachment of Pseudomonas stutzeri and a Bacillus cereus-group strain was investigated. NVN up to 852 microM was not toxic, nor was it an energy source for either organism. Microbial attachment assays were carried out on glass and polylysine slides. with NVN being dispersed in or applied to the surfaces using a polyurethane coating. NVN at 205 microM inhibited Bacillus adhesion on glass slides by 48% and the percentage did not significantly increase at 852 microM. NVN blended into or sprayed onto the coating at 205 micromol/kg did not prevent adhesion. The compound is therefore not useful as an antifouling product under the tested coating conditions.
N-vanillylnonanamide tested as a non-toxic antifoulant, applied to surfaces in a polyurethane coating.
Villa F1, Giacomucci L, Polo A, Principi P, Toniolo L, Levi M, Turri S, Cappitelli F.
Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.