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Norepinephrine

$72

Brand : BIOFRON
Catalogue Number : BN-O0046
Specification : 98%(HPLC)
CAS number : 51-41-2
Formula : C8H11NO3
Molecular Weight : 169.18
PUBCHEM ID : 439260
Volume : 20mg

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Catalogue Number

BN-O0046

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

169.18

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

C1=CC(=C(C=C1C(CN)O)O)O

Synonyms

(−)-Norepinephrine/(-)-NORADRENALINE/1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)-/4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol/L-NOREPINEPHRINE/4-((R)-2-Amino-1-hydroxy-ethyl)-benzene-1,2-diol/1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-/(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol/norepinephrinum [INN_la]/noradrenaline/1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)-/L-NORADRENALINE/(R)-(-)-norepinephrine/(-)-a-(Aminomethyl)protocatechuyl alcohol/4-[(1R)-2-Amino-1-hydroxyethyl]benzol-1,2-diol/Noradrenalin/(-)-norepinephrine/(R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol/(R)-norepinephrine/(R)-noradrenaline/4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol/Norepinephrine/(-)-(R)-Norepinephrine/1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-/4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol

IUPAC Name

Density

1.4±0.1 g/cm3

Solubility

Flash Point

221.5±27.3 °C

Boiling Point

442.6±40.0 °C at 760 mmHg

Melting Point

220-230°C

InChl

InChl Key

SFLSHLFXELFNJZ-QMMMGPOBSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:51-41-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32239840

Abstract

Vasopressin (AVP) is a posterior pituitary hormone initially known for its antidiuretic actions. In this article, we recall the biochemical and pharmacological characteristics of the AVP and its analogues. Currently, its main indication in critical care medicine is vasoplegic shock in view of its vasopressive properties. This strong vasopressive activity is related to the activation of V1 receptors located in the vascular smooth muscle. The scientific evidence of the AVP therapy, and its potential benefits versus norepinephrine in vasoplegic shock, is reviewed in this article. Similarly, we present the other indications of vasopressin in the critical patient, based on recent studies and international guidelines.

Title

[Vasopressin in the critically ill patient].

Author

Cuda L1, Liaudet L1, Ben-Hamouda N1.

Publish date

2020 Apr 1;

PMID

32220188

Abstract

OBJEVTIVE:
To explore the thoracic ascending aortic (TAA) pathophysiological characteristics of heterozygous mutant Myh11 R247C/+ mice under the norepinephrine-induced hypertension mode.

METHODS:
Female heterozygous mutant Myh11 R247C/+ and wild type Myh11 +/+ mice were selected as experimental group (HET group) and control group (WT group),respectively. The hypertensive model was induced by intraperitoneal injection of norepinephrine (NE),and TAA diameter and invasive blood pressure (Bp) data were collected dynamically in real time using high-frequency ultrasound imaging and invasive arterial blood pressure monitoring technique,so as to indirectly analyze TAA compliance of two groups of mice. At the same time,the incidences of hemothorax and TAA rupture were further analyzed by autopsy and histology.

RESULTS:
After injection of NE,heterozygous mice did not show a higher Bp increase percentage in systole or diastole comparing with wildtype mice. However,heterozygous mice exhibited 17% and 32% higher TAA diameter dilation percentage than wildtype ones in systole and diastole respectively. Two heterozygous mice had TAA dissection and rupture,and the incidence of hemothorax in heterozygous mice (3/5) was higher than that in wildtype (0/5).

CONCLUSION:
It was very likely that the altered TAA wall compliance of mutant Myh11 R247C/+ mice had led to a higher TAA dilation degree than that in wildtype,and even could be the potential reason of TAA dissection and rupture.

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

KEYWORDS

High-frequency ultrasound; Invasive blood pressure; Myh11; Norepinephrine; Thoracic ascending aorta

Title

[Pathophysiological Study on Thoracic Ascending Aorta of Mice with Myh11 R247C Heterozygous Mutation in Norepinephrine-induced Hypertension Model].

Author

Yang Y1, Wu ZP2, Shu Y3, Sweeney HL4, Huang B2.

Publish date

2020 Mar;

PMID

32188462

Abstract

BACKGROUND:
Concomitant vasoactive drugs are often required to maintain adequate perfusion pressure in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) receiving hemodynamic support with an axial flow pump (Impella CP).

OBJECTIVE:
To compare the effect of equipotent dosages of epinephrine, dopamine, norepinephrine, and phenylephrine on cardiac work and end-organ perfusion in a porcine model of profound ischemic CS supported with an Impella CP.

METHODS:
CS was induced in 10 pigs by stepwise intracoronary injection of polyvinyl microspheres. Hemodynamic support with Impella CP was initiated followed by blinded crossover to vasoactive treatment with norepinephrine (0.10 μg/kg/min), epinephrine (0.10 μg/kg/min), or dopamine (10 μg/kg/min) for 30 min each. At the end of the study, phenylephrine (10 μg/kg/min) was administered for 20 min. The primary outcome was cardiac workload, a product of pressure-volume area (PVA) and heart rate (HR), measured using the conductance catheter technique. End-organ perfusion was assessed by measuring venous oxygen saturation from the pulmonary artery (SvO2), jugular bulb, and renal vein. Treatment effects were evaluated using multilevel mixed-effects linear regression.

RESULTS:
All catecholamines significantly increased LV stroke work and cardiac work, dopamine to the greatest extend by 341.8 × 103 (mmHg × mL)/min [95% CI (174.1, 509.5), p < 0.0001], and SvO2 significantly improved during all catecholamines. Phenylephrine, a vasoconstrictor, caused a significant increase in cardiac work by 437.8 × 103 (mmHg × mL)/min [95% CI (297.9, 577.6), p < 0.0001] due to increase in potential energy (p = 0.001), but no significant change in LV stroke work. Also, phenylephrine tended to decrease SvO2 (p = 0.063) and increased arterial lactate levels (p = 0.002). CONCLUSION: Catecholamines increased end-organ perfusion at the expense of increased cardiac work, most by dopamine. However, phenylephrine increased cardiac work with no increase in end-organ perfusion.

KEYWORDS

Acute myocardial infarction; Cardiac work; Cardiogenic shock; Mechanical circulatory support; Organ perfusion; Vasopressor

Title

Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock.

Author

Udesen NLJ1, Helgestad OKL2, Banke ABS2, Frederiksen PH2, Josiassen J3, Jensen LO2, Schmidt H4, Edelman ER5,6, Chang BY5, Ravn HB7, Møller JE2,3.

Publish date

2020 Mar 18