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Norgalanthamine

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  • Brand : BIOFRON

  • Catalogue Number : BN-O1713

  • Specification : 98%(HPLC)

  • CAS number : 41303-74-6

  • Formula : C16H19 N O3

  • Molecular Weight : 273.33

  • PUBCHEM ID : 9838394

  • Volume : 2MG

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Catalogue Number

BN-O1713

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

273.33

Appearance

Botanical Source

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C2C3=C(CNCCC34C=CC(CC4O2)O)C=C1

Synonyms

N-Norgalanthamine/N-Demethylgalantamine/Norgalantamine/N-desmethyl galantamine

IUPAC Name

(1S,12S,14R)-9-methoxy-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol

Applications

Density

1.309g/cm3

Solubility

Flash Point

230.744ºC

Boiling Point

457.923ºC at 760 mmHg

Melting Point

142-145ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:41303-74-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

19822478

Abstract

This study was conducted to evaluate the effect of Crinum asiaticum, a plant native to Jeju Island, Korea, on the promotion of hair growth. When rat vibrissa follicles were treated with a 95% ethanol (EtOH) extract of C. asiaticum, the hair-fiber lengths of the vibrissa follicles increased significantly. In addition, after daily topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. Moreover, the extract increased the proliferation of immortalized vibrissa dermal papilla cells. When the vibrissa follicles in the anagen phase were treated with the extract, immunohistochemical analysis revealed that the extract was found to increase the expression of proliferating cell nuclear antigen (PCNA) in the bulb region of the 7-day cultured follicles. In particular, norgalanthamine, a principal of the extract, showed activity that increased the hair-fiber lengths of vibrissa follicles and the proliferation of dermal papilla cells. These results suggest that norgalanthamine, a principal of C. asiaticum, has the potential to promote hair growth via the proliferation of dermal papilla.

Title

Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth.

Author

Kim SC1, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.

Publish date

2010 Jan-Feb

PMID

30606985

Abstract

Norgalanthamine has been shown to possess hair-growth promoting effects, including increase in hair-fiber length in cultured rat vibrissa follicles and increase in dermal papilla cell (DPC) proliferation. However, the intracellular mechanisms that underlie the action of norgalanthamine in DPCs have not been investigated. In this study, we addressed the ability of norgalanthamine to trigger anagen-activating signaling pathways in DPCs. Norgalanthamine significantly increased extracellular signal-regulated kinase (ERK) 1/2 phosphorylation at 0.1 µM, a concentration at which DPC proliferation was also induced. Furthermore, the increases in norgalanthamine-induced ERK 1/2 activation and subsequent DPC proliferation were suppressed by the mitogen-activated protein kinase/ERK kinase (MEK) 1/2 inhibitor, U0126. A 0.1 µM dose of norgalanthamine also increased phosphorylation of AKT, which was followed by an increase in glycogen synthase kinase 3β phosphorylation and nuclear translocation of β-catenin. In addition, LY294002, a phosphatidylinositol 3 kinase (PI3K) inhibitor, blocked the effect of norgalanthamine on DPC proliferation. These results suggest that norgalanthamine can stimulate the anagen phase of the hair cycle in DPCs via activation of the ERK 1/2, PI3K/AKT, and Wnt/β-catenin pathways.

KEYWORDS

AKT; anagen; dermal papilla cell; extracellular signal-regulated kinase 1/2; norgalanthamine; β-catenin

Title

Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways.

Author

Yoon HS1, Kang JI1, Kim SM1, Ko A1, Koh YS1,2, Hyun JW1,2, Yoon SP1, Ahn MJ3, Kim YH4, Kang JH1, Yoo ES1,2, Kang HK1,2.

Publish date

2019