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Notopterol

$143

  • Brand : BIOFRON

  • Catalogue Number : BF-N2010

  • Specification : 98%

  • CAS number : 88206-46-6

  • Formula : C21H22O5

  • Molecular Weight : 354.4

  • PUBCHEM ID : 5320227

  • Volume : 20mg

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Catalogue Number

BF-N2010

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

354.4

Appearance

White needle crystal

Botanical Source

Notopterygium incisum

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

CC(=CC(CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)O)C

Synonyms

4-[(2E)-5-hydroxy-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one/4-{[(2E)-5-hydroxy-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one/4-{[(2E)-5-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one/7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]oxy]-/7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((5-hydroxy-3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-/Notopterol

IUPAC Name

4-[(2E)-5-hydroxy-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one

Density

1.2±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

284.4±30.1 °C

Boiling Point

546.7±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7,9-10,12,15,22H,8,11H2,1-3H3/b14-6+

InChl Key

BKIACVAZUKISOR-MKMNVTDBSA-N

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:88206-46-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28115935

Title

Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract.

Author

Teye Azietaku J1, Yu XA1, Li J1, Hao J1, Cao J2, An M3, Tan Z3, Chang YX1.

Publish date

2016


Description :

Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines. PUMID/DOI:19653148 Planta Med. 2010 Jan;76(1):82-5. Bioassay-guided fractionation of the antiproliferative chloroform extract of the traditional Chinese medicine Qiang-Huo (Notopterygium incisum) led to the isolation of nine linear furocoumarins (1- 9). All the isolates were tested against two human cancer cell lines (HepG-2 and MCF-7) and a rat cancer cell line (C6) using the MTT assay method. Among them, notopol (1), Notopterol (2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene (3), and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene (4) showed significant antiproliferative activity against the HepG-2 and C6 cancer cell lines, with IC(50) values of 7.7-24.8 microg/mL (5-FU: ca. 5 microg/mL). Compounds 1- 3 also showed moderate cytotoxicity against the MCF-7 cancer cell line, with IC(50) values of 39.4-61.3 microg/mL (5-FU: 17.3 microg/mL). The cell cycle-specific inhibition and apoptosis induced by compounds 1 and 2 were determined using flow cytometry. The structure-activity relationship (SAR) is briefly discussed herein. It was found that the presence of a free hydroxy at the lipophilic side chain linked to C-5 of the linear furocoumarins was essential for their in vitro antiproliferative activity. Analgesic component of Notopterygium incisum Ting. PUMID/DOI:8339339 Chem Pharm Bull (Tokyo). 1993 May;41(5):926-9. Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.