White crystalline powder
Fructus Ligustri Lucidi
oleosid-11-methylester/elenol acid glucoside/elenolic acid glucoside
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:60539-23-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Thsd7a (Thrombospondin type 1 domain containing 7a) is a critical transmembrane protein. Studies have indicated that Thsd7a was associated with cytoskeletal organization, cell migration and filopodia formation. However, the involvement of Thsd7a remains elusive in human Esophageal Squamous Cell Carcinoma (ESCC). Consequently, immunohistochemistry and reverse transcription-polymerase chain reaction were utilized to study the correlation between the expression of Thsd7a and clinical-pathological characteristics. The influence of Thsd7a on apoptosis, cell proliferating activity, cell cycle, migratory and invasive capacity was determined in Eca 109 and EC 9706 cell lines in vitro. And the influence on proliferating activity was testified using naked mice model in vivo. In addition, the potential molecular mechanism was tested by microarray. It was discovered that there is a certain correlation between Thsd7a and the Kazakh ESCC. By knocking out Thsd7a, the invasion, migration and proliferation could be decreased. And it could also arrest the cell cycle at G1 phase and increase the apoptosis rate. It was further verified that Thsd7a had obvious effect on proliferation in naked mice with xenograft of Eca109 cells. Finally, it was uncovered by microarray analysis that a variety of tumor genes and pathways related to Thsd7a. Together, it was demonstrated that Thsd7a might have a certain degree of carcinogenesis in ESCC.
esophageal squamous cell carcinoma, Thsd7a, Kazakh patients, prognosis, function
Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang
Zhichao Hou,1 Abulajiang Abudureheman,1 Lei Wang,1 Ayshamgul Hasim,2 Julaiti Ainiwaer,1 Haiping Zhang,1 Madiniyat Niyaz,3 Halmurat Upur,4 and Ilyar Sheyhidin1
2017 Sep 1
The increased incidence of bile duct injuries (BDIs) after the adoption of laparoscopic cholecystectomy has been well documented. However, the longitudinal impact of bile leaks and BDIs on survival and healthcare use have not been studied adequately. The aims of this analysis were to determine the incidence, long-term outcomes, and costs of bile leaks and ductal injuries in a large population.
The California Office of Statewide Health Planning and Development database was queried from 2005 to 2014. Bile leaks, BDIs, and their management strategy were defined. Survival was calculated by Kaplan-Meier failure estimates with multivariable regression and propensity analyses. Cost analyses used inflation adjustments and institution-specific cost-to-charge ratios.
Of 711,454 cholecystecomies, bile leaks occurred in 3,551 patients (0.50%) and were managed almost exclusively by endoscopists. Bile duct injuries occurred in 1,584 patients (0.22%) with 84% managed surgically. Patients with a bile leak were more likely to die at 1 year (2.4% vs 1.4%; odds ratio 1.85; p < 0.001). Similarly, BDI patients had an increased 1-year mortality (7.2% vs 1.3%; odds ratio 2.04; p < 0.0001). Survival of BDI patients was better with an operative approach (odds ratio 0.19; p < 0.001) when compared with endoscopic management. Operatively managed BDIs were also associated with fewer emergency department visits and readmissions, as well as lower cumulative costs at 1 year ($60,539 vs $118,245; p < 0.001). CONCLUSIONS The 0.22% incidence of BDIs observed in California is lower than reported in the first decade after the introduction of laparoscopic cholecystectomy. Bile leaks are 2.3 times more common than BDIs. Patients with a bile leak or BDI have diminished survival. Surgical repair of a BDI leads to enhanced survival and reduced cumulative cost compared with endoscopic management. Laparoscopic cholecystectomy is one of the most commonly performed operations in the US, accounting for approximately 1.2 million cases per year.1 When undertaken electively, this procedure is safe, with more than half of the cases performed on an outpatient basis with same-day discharge. However, major morbidity occurs in approximately 5% of patients,2 with the most morbid complication being a bile duct injury (BDI). After the adoption of laparoscopic cholecystectomy, the incidence of BDI has increased from 0.1% to 0.2%3 during the open cholecystectomy era to 0.4% to 0.6%.4,5 However, recent analyses from Europe6 and the US7,8 suggest that the incidence of BDIs has returned to prelaparoscopy rates. Although the early clinical outcomes of BDIs have been well documented, the longitudinal impact of bile leaks and ductal injuries on survival, healthcare use, and cost have been less well defined. Most patients with BDIs are referred to tertiary centers for surgical, endoscopic, or percutaneous management. As such, longitudinal tracking of these patients with complete follow-up is difficult. Additionally, little is known about the incidence or long-term consequences of cystic duct leaks, which are most commonly managed successfully in the short-term by endoscopists. As part of a quality review effort, the California Office of Statewide Health Planning and Development (OSHPD) contracted the authors to assess these issues further. The aims of this analysis were to determine the incidence and long-term outcomes of bile leaks and ductal injuries managed surgically, endoscopically, or percutaneously in a large population.
Diminished Survival in Patients with Bile Leak and Ductal Injury: Management Strategy and Outcomes
Zhi Ven Fong, MD, MPH, Henry A Pitt, MD, FACS, Steven M Strasberg, MD, FACS, Andrew P Loehrer, MD, MPH, Jason K Sicklick, MD, FACS, Mark A Talamini, MD, MBA, FACS, Keith D Lillemoe, MD, FACS, David C Chang, PhD, MPH, MBA, and the California Cholecystectomy Group
2018 Jul 20.
Chimerism occurs when two genetically distinct conspecific individuals fuse together generating a single entity. Coalescence and chimerism in red seaweeds has been positively related to an increase in body size, and the consequent reduction in susceptibility to mortality factors, thus increasing survival, reproductive potential and tolerance to stress in contrast to genetically homogeneous organisms. In addition, they showed that a particular pattern of post-fusion growth maintains higher genetic diversity and chimerism in the holdfast but homogenous axes. In Chilean kelps (brown seaweeds), intraorganismal genetic heterogeneity (IGH) and holdfast coalescence has been described in previous research, but the extent of chimerism in wild populations and the patterns of distribution of the genetically heterogeneous thallus zone have scarcely been studied. Since kelps are under continuous harvesting, with enormous social, ecological and economic importance, natural chimerism can be considered a priceless in-situ reservoir of natural genetic resources and variability. In this study, we therefore examined the frequency of IGH and chimerism in three harvested populations of Lessonia spicata. We then evaluated whether chimeric wild-type holdfasts show higher genetic diversity than erect axes (stipe and lamina) and explored the impact of this on the traditional estimation of genetic diversity at the population level. We found a high frequency of IGH (60-100%) and chimerism (33.3-86.7%), varying according to the studied population. We evidenced that chimerism occurs mostly in holdfasts, exhibiting heterogeneous tissues, whereas stipes and lamina were more homogeneous, generating a vertical gradient of allele and genotype abundance as well as divergence, constituting the first time “within- plant” genetic patterns have been reported in kelps. This is very different from the chimeric patterns described in land plants and animals. Finally, we evidenced that IGH affected genetic differentiation among populations, showed lower levels of FST index when we compared holdfast than lamina samples. In the light of this, future studies should evaluate the significance of chimeric holdfasts in their ability to increase kelps resilience, improve restoration and ecosystem service.
Frequency of chimerism in populations of the kelp Lessonia spicata in central Chile
Alejandra V. Gonzalez#1,* and Bernabe Santelices#2